Abstract
The utility of in vitro generated kinetic data to provide quantitative prediction of in vivo pharmacokinetic behavior is well established and forms a cornerstone of many research projects in drug metabolism and disposition, particularly within the pharmaceutical industry. This issue provides several excellent examples of the use of in vitro techniques for prediction of human pharmacokinetics (PK). The general area of in vitro–in vivo extrapolation (IVIVE) is broad and hence the spectrum of topics covers various aspects drug clearance and distribution and drug-drug interactions. Some articles were commissioned whereas others were identified during the reviewing process. Overall they provide a snapshot of activity at the end of 2013. They document that whereas the translation of some in vitro approaches is now established, other areas are in their infancy and need more development.
Footnotes
- Received October 11, 2013.
- Accepted October 11, 2013.
- Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics
DMD articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|