Research ArticleArticle
Metabolism and Disposition of Oral Dabrafenib in Cancer Patients: Proposed Participation of Aryl Nitrogen in Carbon-Carbon Bond Cleavage via Decarboxylation following Enzymatic Oxidation
David A. Bershas, Daniele Ouellet, Donna B. Mamaril-Fishman, Noelia Nebot, Stanley W. Carson, Samuel C. Blackman, Royce A. Morrison, Jerry L. Adams, Kristen E. Jurusik, Dana M. Knecht, Peter D. Gorycki and Lauren E. Richards-Peterson
Drug Metabolism and Disposition December 2013, 41 (12) 2215-2224; DOI: https://doi.org/10.1124/dmd.113.053785
David A. Bershas
Department of Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, King of Prussia, Pennsylvania (D.A.B., D.B.M.-F., K.E.J., D.M.K., P.D.G., L.E.R.-P.); Department of Clinical Pharmacology Modeling and Simulation (D.O., N.N.) and Department of Oncology R&D (S.W.C.), GlaxoSmithKline, Research Triangle Park, North Carolina; Department of Oncology R&D, GlaxoSmithKline, Collegeville, Pennsylvania (S.C.B., J.L.A.); and Comprehensive Clinical Development NW, Tacoma, Washington (R.A.M)
Daniele Ouellet
Department of Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, King of Prussia, Pennsylvania (D.A.B., D.B.M.-F., K.E.J., D.M.K., P.D.G., L.E.R.-P.); Department of Clinical Pharmacology Modeling and Simulation (D.O., N.N.) and Department of Oncology R&D (S.W.C.), GlaxoSmithKline, Research Triangle Park, North Carolina; Department of Oncology R&D, GlaxoSmithKline, Collegeville, Pennsylvania (S.C.B., J.L.A.); and Comprehensive Clinical Development NW, Tacoma, Washington (R.A.M)
Donna B. Mamaril-Fishman
Department of Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, King of Prussia, Pennsylvania (D.A.B., D.B.M.-F., K.E.J., D.M.K., P.D.G., L.E.R.-P.); Department of Clinical Pharmacology Modeling and Simulation (D.O., N.N.) and Department of Oncology R&D (S.W.C.), GlaxoSmithKline, Research Triangle Park, North Carolina; Department of Oncology R&D, GlaxoSmithKline, Collegeville, Pennsylvania (S.C.B., J.L.A.); and Comprehensive Clinical Development NW, Tacoma, Washington (R.A.M)
Noelia Nebot
Department of Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, King of Prussia, Pennsylvania (D.A.B., D.B.M.-F., K.E.J., D.M.K., P.D.G., L.E.R.-P.); Department of Clinical Pharmacology Modeling and Simulation (D.O., N.N.) and Department of Oncology R&D (S.W.C.), GlaxoSmithKline, Research Triangle Park, North Carolina; Department of Oncology R&D, GlaxoSmithKline, Collegeville, Pennsylvania (S.C.B., J.L.A.); and Comprehensive Clinical Development NW, Tacoma, Washington (R.A.M)
Stanley W. Carson
Department of Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, King of Prussia, Pennsylvania (D.A.B., D.B.M.-F., K.E.J., D.M.K., P.D.G., L.E.R.-P.); Department of Clinical Pharmacology Modeling and Simulation (D.O., N.N.) and Department of Oncology R&D (S.W.C.), GlaxoSmithKline, Research Triangle Park, North Carolina; Department of Oncology R&D, GlaxoSmithKline, Collegeville, Pennsylvania (S.C.B., J.L.A.); and Comprehensive Clinical Development NW, Tacoma, Washington (R.A.M)
Samuel C. Blackman
Department of Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, King of Prussia, Pennsylvania (D.A.B., D.B.M.-F., K.E.J., D.M.K., P.D.G., L.E.R.-P.); Department of Clinical Pharmacology Modeling and Simulation (D.O., N.N.) and Department of Oncology R&D (S.W.C.), GlaxoSmithKline, Research Triangle Park, North Carolina; Department of Oncology R&D, GlaxoSmithKline, Collegeville, Pennsylvania (S.C.B., J.L.A.); and Comprehensive Clinical Development NW, Tacoma, Washington (R.A.M)
Royce A. Morrison
Department of Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, King of Prussia, Pennsylvania (D.A.B., D.B.M.-F., K.E.J., D.M.K., P.D.G., L.E.R.-P.); Department of Clinical Pharmacology Modeling and Simulation (D.O., N.N.) and Department of Oncology R&D (S.W.C.), GlaxoSmithKline, Research Triangle Park, North Carolina; Department of Oncology R&D, GlaxoSmithKline, Collegeville, Pennsylvania (S.C.B., J.L.A.); and Comprehensive Clinical Development NW, Tacoma, Washington (R.A.M)
Jerry L. Adams
Department of Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, King of Prussia, Pennsylvania (D.A.B., D.B.M.-F., K.E.J., D.M.K., P.D.G., L.E.R.-P.); Department of Clinical Pharmacology Modeling and Simulation (D.O., N.N.) and Department of Oncology R&D (S.W.C.), GlaxoSmithKline, Research Triangle Park, North Carolina; Department of Oncology R&D, GlaxoSmithKline, Collegeville, Pennsylvania (S.C.B., J.L.A.); and Comprehensive Clinical Development NW, Tacoma, Washington (R.A.M)
Kristen E. Jurusik
Department of Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, King of Prussia, Pennsylvania (D.A.B., D.B.M.-F., K.E.J., D.M.K., P.D.G., L.E.R.-P.); Department of Clinical Pharmacology Modeling and Simulation (D.O., N.N.) and Department of Oncology R&D (S.W.C.), GlaxoSmithKline, Research Triangle Park, North Carolina; Department of Oncology R&D, GlaxoSmithKline, Collegeville, Pennsylvania (S.C.B., J.L.A.); and Comprehensive Clinical Development NW, Tacoma, Washington (R.A.M)
Dana M. Knecht
Department of Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, King of Prussia, Pennsylvania (D.A.B., D.B.M.-F., K.E.J., D.M.K., P.D.G., L.E.R.-P.); Department of Clinical Pharmacology Modeling and Simulation (D.O., N.N.) and Department of Oncology R&D (S.W.C.), GlaxoSmithKline, Research Triangle Park, North Carolina; Department of Oncology R&D, GlaxoSmithKline, Collegeville, Pennsylvania (S.C.B., J.L.A.); and Comprehensive Clinical Development NW, Tacoma, Washington (R.A.M)
Peter D. Gorycki
Department of Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, King of Prussia, Pennsylvania (D.A.B., D.B.M.-F., K.E.J., D.M.K., P.D.G., L.E.R.-P.); Department of Clinical Pharmacology Modeling and Simulation (D.O., N.N.) and Department of Oncology R&D (S.W.C.), GlaxoSmithKline, Research Triangle Park, North Carolina; Department of Oncology R&D, GlaxoSmithKline, Collegeville, Pennsylvania (S.C.B., J.L.A.); and Comprehensive Clinical Development NW, Tacoma, Washington (R.A.M)
Lauren E. Richards-Peterson
Department of Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, King of Prussia, Pennsylvania (D.A.B., D.B.M.-F., K.E.J., D.M.K., P.D.G., L.E.R.-P.); Department of Clinical Pharmacology Modeling and Simulation (D.O., N.N.) and Department of Oncology R&D (S.W.C.), GlaxoSmithKline, Research Triangle Park, North Carolina; Department of Oncology R&D, GlaxoSmithKline, Collegeville, Pennsylvania (S.C.B., J.L.A.); and Comprehensive Clinical Development NW, Tacoma, Washington (R.A.M)
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Research ArticleArticle
Dabrafenib Disposition in Cancer Patients
David A. Bershas, Daniele Ouellet, Donna B. Mamaril-Fishman, Noelia Nebot, Stanley W. Carson, Samuel C. Blackman, Royce A. Morrison, Jerry L. Adams, Kristen E. Jurusik, Dana M. Knecht, Peter D. Gorycki and Lauren E. Richards-Peterson
Drug Metabolism and Disposition December 1, 2013, 41 (12) 2215-2224; DOI: https://doi.org/10.1124/dmd.113.053785
Research ArticleArticle
Dabrafenib Disposition in Cancer Patients
David A. Bershas, Daniele Ouellet, Donna B. Mamaril-Fishman, Noelia Nebot, Stanley W. Carson, Samuel C. Blackman, Royce A. Morrison, Jerry L. Adams, Kristen E. Jurusik, Dana M. Knecht, Peter D. Gorycki and Lauren E. Richards-Peterson
Drug Metabolism and Disposition December 1, 2013, 41 (12) 2215-2224; DOI: https://doi.org/10.1124/dmd.113.053785
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