Research ArticleArticle
Evaluation of Metabolism and Disposition of GDC-0152 in Rats Using 14C Labeling Strategy at Two Different Positions: A Novel Formation of Hippuric Acid from 4-Phenyl-5-Amino-1,2,3-Thiadiazole
Qin Yue, Teresa Mulder, Patrick J. Rudewicz, Eric Solon, Nageshwar Budha, Joseph A Ware, Joseph Lyssikatos, Cornelis E.C.A. Hop, Harvey Wong and S. Cyrus Khojasteh
Drug Metabolism and Disposition February 2013, 41 (2) 508-517; DOI: https://doi.org/10.1124/dmd.112.047019
Qin Yue
Departments of Drug Metabolism and Pharmacokinetics (Q.Y., T.M., P.J.R., C.E.C.A.H., H.W., S.C.K.), Clinical Pharmacology (N.B., J.A.W.), and Medicinal Chemistry (J.L.), Genentech Inc., South San Francisco, California; and QPS, LLC., Newark, Delaware (E.S.)
Teresa Mulder
Departments of Drug Metabolism and Pharmacokinetics (Q.Y., T.M., P.J.R., C.E.C.A.H., H.W., S.C.K.), Clinical Pharmacology (N.B., J.A.W.), and Medicinal Chemistry (J.L.), Genentech Inc., South San Francisco, California; and QPS, LLC., Newark, Delaware (E.S.)
Patrick J. Rudewicz
Departments of Drug Metabolism and Pharmacokinetics (Q.Y., T.M., P.J.R., C.E.C.A.H., H.W., S.C.K.), Clinical Pharmacology (N.B., J.A.W.), and Medicinal Chemistry (J.L.), Genentech Inc., South San Francisco, California; and QPS, LLC., Newark, Delaware (E.S.)
Eric Solon
Departments of Drug Metabolism and Pharmacokinetics (Q.Y., T.M., P.J.R., C.E.C.A.H., H.W., S.C.K.), Clinical Pharmacology (N.B., J.A.W.), and Medicinal Chemistry (J.L.), Genentech Inc., South San Francisco, California; and QPS, LLC., Newark, Delaware (E.S.)
Nageshwar Budha
Departments of Drug Metabolism and Pharmacokinetics (Q.Y., T.M., P.J.R., C.E.C.A.H., H.W., S.C.K.), Clinical Pharmacology (N.B., J.A.W.), and Medicinal Chemistry (J.L.), Genentech Inc., South San Francisco, California; and QPS, LLC., Newark, Delaware (E.S.)
Joseph A Ware
Departments of Drug Metabolism and Pharmacokinetics (Q.Y., T.M., P.J.R., C.E.C.A.H., H.W., S.C.K.), Clinical Pharmacology (N.B., J.A.W.), and Medicinal Chemistry (J.L.), Genentech Inc., South San Francisco, California; and QPS, LLC., Newark, Delaware (E.S.)
Joseph Lyssikatos
Departments of Drug Metabolism and Pharmacokinetics (Q.Y., T.M., P.J.R., C.E.C.A.H., H.W., S.C.K.), Clinical Pharmacology (N.B., J.A.W.), and Medicinal Chemistry (J.L.), Genentech Inc., South San Francisco, California; and QPS, LLC., Newark, Delaware (E.S.)
Cornelis E.C.A. Hop
Departments of Drug Metabolism and Pharmacokinetics (Q.Y., T.M., P.J.R., C.E.C.A.H., H.W., S.C.K.), Clinical Pharmacology (N.B., J.A.W.), and Medicinal Chemistry (J.L.), Genentech Inc., South San Francisco, California; and QPS, LLC., Newark, Delaware (E.S.)
Harvey Wong
Departments of Drug Metabolism and Pharmacokinetics (Q.Y., T.M., P.J.R., C.E.C.A.H., H.W., S.C.K.), Clinical Pharmacology (N.B., J.A.W.), and Medicinal Chemistry (J.L.), Genentech Inc., South San Francisco, California; and QPS, LLC., Newark, Delaware (E.S.)
S. Cyrus Khojasteh
Departments of Drug Metabolism and Pharmacokinetics (Q.Y., T.M., P.J.R., C.E.C.A.H., H.W., S.C.K.), Clinical Pharmacology (N.B., J.A.W.), and Medicinal Chemistry (J.L.), Genentech Inc., South San Francisco, California; and QPS, LLC., Newark, Delaware (E.S.)
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Research ArticleArticle
A Novel Biotransformation from GDC-0152 to Hippuric Acid
Qin Yue, Teresa Mulder, Patrick J. Rudewicz, Eric Solon, Nageshwar Budha, Joseph A Ware, Joseph Lyssikatos, Cornelis E.C.A. Hop, Harvey Wong and S. Cyrus Khojasteh
Drug Metabolism and Disposition February 1, 2013, 41 (2) 508-517; DOI: https://doi.org/10.1124/dmd.112.047019
Research ArticleArticle
A Novel Biotransformation from GDC-0152 to Hippuric Acid
Qin Yue, Teresa Mulder, Patrick J. Rudewicz, Eric Solon, Nageshwar Budha, Joseph A Ware, Joseph Lyssikatos, Cornelis E.C.A. Hop, Harvey Wong and S. Cyrus Khojasteh
Drug Metabolism and Disposition February 1, 2013, 41 (2) 508-517; DOI: https://doi.org/10.1124/dmd.112.047019
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