Research ArticleArticle
Compartmental and Enzyme Kinetic Modeling To Elucidate the Biotransformation Pathway of a Centrally Acting Antitrypanosomal Prodrug
Claudia N. Generaux, Garrett R. Ainslie, Arlene S. Bridges, Mohamed A. Ismail, David W. Boykin, Richard R. Tidwell, Dhiren R. Thakker and Mary F. Paine
Drug Metabolism and Disposition February 2013, 41 (2) 518-528; DOI: https://doi.org/10.1124/dmd.112.048231
Claudia N. Generaux
Divisions of Molecular Pharmaceutics (C.N.G.) and Pharmacotherapy and Experimental Therapeutics (D.R.T., M.F.P.), University of North Carolina Eshelman School of Pharmacy and Curriculum in Toxicology (G.R.A., M.F.P.) and Department of Pathology and Laboratory Medicine, School of Medicine (A.S.B., R.R.T.), The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; and Department of Chemistry, Georgia State University, Atlanta, Georgia (M.A.I., D.W.B.)
Garrett R. Ainslie
Divisions of Molecular Pharmaceutics (C.N.G.) and Pharmacotherapy and Experimental Therapeutics (D.R.T., M.F.P.), University of North Carolina Eshelman School of Pharmacy and Curriculum in Toxicology (G.R.A., M.F.P.) and Department of Pathology and Laboratory Medicine, School of Medicine (A.S.B., R.R.T.), The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; and Department of Chemistry, Georgia State University, Atlanta, Georgia (M.A.I., D.W.B.)
Arlene S. Bridges
Divisions of Molecular Pharmaceutics (C.N.G.) and Pharmacotherapy and Experimental Therapeutics (D.R.T., M.F.P.), University of North Carolina Eshelman School of Pharmacy and Curriculum in Toxicology (G.R.A., M.F.P.) and Department of Pathology and Laboratory Medicine, School of Medicine (A.S.B., R.R.T.), The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; and Department of Chemistry, Georgia State University, Atlanta, Georgia (M.A.I., D.W.B.)
Mohamed A. Ismail
Divisions of Molecular Pharmaceutics (C.N.G.) and Pharmacotherapy and Experimental Therapeutics (D.R.T., M.F.P.), University of North Carolina Eshelman School of Pharmacy and Curriculum in Toxicology (G.R.A., M.F.P.) and Department of Pathology and Laboratory Medicine, School of Medicine (A.S.B., R.R.T.), The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; and Department of Chemistry, Georgia State University, Atlanta, Georgia (M.A.I., D.W.B.)
David W. Boykin
Divisions of Molecular Pharmaceutics (C.N.G.) and Pharmacotherapy and Experimental Therapeutics (D.R.T., M.F.P.), University of North Carolina Eshelman School of Pharmacy and Curriculum in Toxicology (G.R.A., M.F.P.) and Department of Pathology and Laboratory Medicine, School of Medicine (A.S.B., R.R.T.), The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; and Department of Chemistry, Georgia State University, Atlanta, Georgia (M.A.I., D.W.B.)
Richard R. Tidwell
Divisions of Molecular Pharmaceutics (C.N.G.) and Pharmacotherapy and Experimental Therapeutics (D.R.T., M.F.P.), University of North Carolina Eshelman School of Pharmacy and Curriculum in Toxicology (G.R.A., M.F.P.) and Department of Pathology and Laboratory Medicine, School of Medicine (A.S.B., R.R.T.), The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; and Department of Chemistry, Georgia State University, Atlanta, Georgia (M.A.I., D.W.B.)
Dhiren R. Thakker
Divisions of Molecular Pharmaceutics (C.N.G.) and Pharmacotherapy and Experimental Therapeutics (D.R.T., M.F.P.), University of North Carolina Eshelman School of Pharmacy and Curriculum in Toxicology (G.R.A., M.F.P.) and Department of Pathology and Laboratory Medicine, School of Medicine (A.S.B., R.R.T.), The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; and Department of Chemistry, Georgia State University, Atlanta, Georgia (M.A.I., D.W.B.)
Mary F. Paine
Divisions of Molecular Pharmaceutics (C.N.G.) and Pharmacotherapy and Experimental Therapeutics (D.R.T., M.F.P.), University of North Carolina Eshelman School of Pharmacy and Curriculum in Toxicology (G.R.A., M.F.P.) and Department of Pathology and Laboratory Medicine, School of Medicine (A.S.B., R.R.T.), The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; and Department of Chemistry, Georgia State University, Atlanta, Georgia (M.A.I., D.W.B.)
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Research ArticleArticle
Metabolism of a Centrally Acting Antitrypanosomal Prodrug
Claudia N. Generaux, Garrett R. Ainslie, Arlene S. Bridges, Mohamed A. Ismail, David W. Boykin, Richard R. Tidwell, Dhiren R. Thakker and Mary F. Paine
Drug Metabolism and Disposition February 1, 2013, 41 (2) 518-528; DOI: https://doi.org/10.1124/dmd.112.048231
Research ArticleArticle
Metabolism of a Centrally Acting Antitrypanosomal Prodrug
Claudia N. Generaux, Garrett R. Ainslie, Arlene S. Bridges, Mohamed A. Ismail, David W. Boykin, Richard R. Tidwell, Dhiren R. Thakker and Mary F. Paine
Drug Metabolism and Disposition February 1, 2013, 41 (2) 518-528; DOI: https://doi.org/10.1124/dmd.112.048231
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