Cover Caption

About the cover: Representative sagittal PET summation images (0–60 minutes) of [11C]TQD for (A) scan 1 in wild-type (WT), Mdr1a/b(2/2), Bcrp1(2/2), and Mdr1a/b(2/2)Bcrp1(2/2) mice. The radiation scale is set from 0.0% to 10.0% injected dose per gram (%ID/g). (C) Mean (6 S.E.M.) whole-brain time-activity curves of all mice types (WT, black squares; Mdr1a/b(2/2), red circles; Bcrp1(2/2), green triangles Mdr1a/b(2/2)Bcrp1(2/2), blue diamonds; n = 5 per type) are shown. Unlabeled TQD (15 mg/kg) was administered as an intravenous bolus at 60 minutes after start of scan 1 (C). Application of cold TQD is indicated by an arrow. See article by Bankstahl et al. on page 754 of this issue.