Application of a Physiologically Based Pharmacokinetic Model to Assess Propofol Hepatic and Renal Glucuronidation in Isolation: Utility of In Vitro and In Vivo Data

Katherine L. Gill; Michael Gertz; J. Brian Houston; Aleksandra Galetin

doi:10.1124/dmd.112.050294

Research ArticleArticle

Application of a Physiologically Based Pharmacokinetic Model to Assess Propofol Hepatic and Renal Glucuronidation in Isolation: Utility of In Vitro and In Vivo Data

Katherine L. Gill, Michael Gertz, J. Brian Houston and Aleksandra Galetin

Drug Metabolism and Disposition April 2013, 41 (4) 744-753; DOI: https://doi.org/10.1124/dmd.112.050294

Katherine L. Gill

Centre for Applied Pharmacokinetic Research, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, United Kingdom

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Michael Gertz

Centre for Applied Pharmacokinetic Research, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, United Kingdom

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J. Brian Houston

Centre for Applied Pharmacokinetic Research, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, United Kingdom

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Aleksandra Galetin

Centre for Applied Pharmacokinetic Research, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, United Kingdom

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Drug Metabolism and Disposition

Vol. 41, Issue 4

1 Apr 2013

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