Research ArticleArticle
Mechanistic Pharmacokinetic-Pharmacodynamic Modeling of BACE1 Inhibition in Monkeys: Development of a Predictive Model for Amyloid Precursor Protein Processing
Xingrong Liu, Harvey Wong, Kimberly Scearce-Levie, Ryan J. Watts, Melis Coraggio, Young G. Shin, Kun Peng, Kristin R. Wildsmith, Jasvinder K. Atwal, Jason Mango, Stephen P. Schauer, Kelly Regal, Kevin W. Hunt, Allen A. Thomas, Michael Siu, Joseph Lyssikatos, Gauri Deshmukh and Cornelis E. C. A. Hop
Drug Metabolism and Disposition July 2013, 41 (7) 1319-1328; DOI: https://doi.org/10.1124/dmd.112.050864
Xingrong Liu
Genentech Inc., South San Francisco, California (X.L., H.W., K.S.-L., R.J.W., M.C., Y.G.S., K.P., K.R.W., J.K.A., J.M., S.P.S., M.S., J.L., G.D., C.E.C.A.H.); and Array BioPharma Inc., Boulder, Colorado (K.R., K.W.H., A.A.T.)
Harvey Wong
Genentech Inc., South San Francisco, California (X.L., H.W., K.S.-L., R.J.W., M.C., Y.G.S., K.P., K.R.W., J.K.A., J.M., S.P.S., M.S., J.L., G.D., C.E.C.A.H.); and Array BioPharma Inc., Boulder, Colorado (K.R., K.W.H., A.A.T.)
Kimberly Scearce-Levie
Genentech Inc., South San Francisco, California (X.L., H.W., K.S.-L., R.J.W., M.C., Y.G.S., K.P., K.R.W., J.K.A., J.M., S.P.S., M.S., J.L., G.D., C.E.C.A.H.); and Array BioPharma Inc., Boulder, Colorado (K.R., K.W.H., A.A.T.)
Ryan J. Watts
Genentech Inc., South San Francisco, California (X.L., H.W., K.S.-L., R.J.W., M.C., Y.G.S., K.P., K.R.W., J.K.A., J.M., S.P.S., M.S., J.L., G.D., C.E.C.A.H.); and Array BioPharma Inc., Boulder, Colorado (K.R., K.W.H., A.A.T.)
Melis Coraggio
Genentech Inc., South San Francisco, California (X.L., H.W., K.S.-L., R.J.W., M.C., Y.G.S., K.P., K.R.W., J.K.A., J.M., S.P.S., M.S., J.L., G.D., C.E.C.A.H.); and Array BioPharma Inc., Boulder, Colorado (K.R., K.W.H., A.A.T.)
Young G. Shin
Genentech Inc., South San Francisco, California (X.L., H.W., K.S.-L., R.J.W., M.C., Y.G.S., K.P., K.R.W., J.K.A., J.M., S.P.S., M.S., J.L., G.D., C.E.C.A.H.); and Array BioPharma Inc., Boulder, Colorado (K.R., K.W.H., A.A.T.)
Kun Peng
Genentech Inc., South San Francisco, California (X.L., H.W., K.S.-L., R.J.W., M.C., Y.G.S., K.P., K.R.W., J.K.A., J.M., S.P.S., M.S., J.L., G.D., C.E.C.A.H.); and Array BioPharma Inc., Boulder, Colorado (K.R., K.W.H., A.A.T.)
Kristin R. Wildsmith
Genentech Inc., South San Francisco, California (X.L., H.W., K.S.-L., R.J.W., M.C., Y.G.S., K.P., K.R.W., J.K.A., J.M., S.P.S., M.S., J.L., G.D., C.E.C.A.H.); and Array BioPharma Inc., Boulder, Colorado (K.R., K.W.H., A.A.T.)
Jasvinder K. Atwal
Genentech Inc., South San Francisco, California (X.L., H.W., K.S.-L., R.J.W., M.C., Y.G.S., K.P., K.R.W., J.K.A., J.M., S.P.S., M.S., J.L., G.D., C.E.C.A.H.); and Array BioPharma Inc., Boulder, Colorado (K.R., K.W.H., A.A.T.)
Jason Mango
Genentech Inc., South San Francisco, California (X.L., H.W., K.S.-L., R.J.W., M.C., Y.G.S., K.P., K.R.W., J.K.A., J.M., S.P.S., M.S., J.L., G.D., C.E.C.A.H.); and Array BioPharma Inc., Boulder, Colorado (K.R., K.W.H., A.A.T.)
Stephen P. Schauer
Genentech Inc., South San Francisco, California (X.L., H.W., K.S.-L., R.J.W., M.C., Y.G.S., K.P., K.R.W., J.K.A., J.M., S.P.S., M.S., J.L., G.D., C.E.C.A.H.); and Array BioPharma Inc., Boulder, Colorado (K.R., K.W.H., A.A.T.)
Kelly Regal
Genentech Inc., South San Francisco, California (X.L., H.W., K.S.-L., R.J.W., M.C., Y.G.S., K.P., K.R.W., J.K.A., J.M., S.P.S., M.S., J.L., G.D., C.E.C.A.H.); and Array BioPharma Inc., Boulder, Colorado (K.R., K.W.H., A.A.T.)
Kevin W. Hunt
Genentech Inc., South San Francisco, California (X.L., H.W., K.S.-L., R.J.W., M.C., Y.G.S., K.P., K.R.W., J.K.A., J.M., S.P.S., M.S., J.L., G.D., C.E.C.A.H.); and Array BioPharma Inc., Boulder, Colorado (K.R., K.W.H., A.A.T.)
Allen A. Thomas
Genentech Inc., South San Francisco, California (X.L., H.W., K.S.-L., R.J.W., M.C., Y.G.S., K.P., K.R.W., J.K.A., J.M., S.P.S., M.S., J.L., G.D., C.E.C.A.H.); and Array BioPharma Inc., Boulder, Colorado (K.R., K.W.H., A.A.T.)
Michael Siu
Genentech Inc., South San Francisco, California (X.L., H.W., K.S.-L., R.J.W., M.C., Y.G.S., K.P., K.R.W., J.K.A., J.M., S.P.S., M.S., J.L., G.D., C.E.C.A.H.); and Array BioPharma Inc., Boulder, Colorado (K.R., K.W.H., A.A.T.)
Joseph Lyssikatos
Genentech Inc., South San Francisco, California (X.L., H.W., K.S.-L., R.J.W., M.C., Y.G.S., K.P., K.R.W., J.K.A., J.M., S.P.S., M.S., J.L., G.D., C.E.C.A.H.); and Array BioPharma Inc., Boulder, Colorado (K.R., K.W.H., A.A.T.)
Gauri Deshmukh
Genentech Inc., South San Francisco, California (X.L., H.W., K.S.-L., R.J.W., M.C., Y.G.S., K.P., K.R.W., J.K.A., J.M., S.P.S., M.S., J.L., G.D., C.E.C.A.H.); and Array BioPharma Inc., Boulder, Colorado (K.R., K.W.H., A.A.T.)
Cornelis E. C. A. Hop
Genentech Inc., South San Francisco, California (X.L., H.W., K.S.-L., R.J.W., M.C., Y.G.S., K.P., K.R.W., J.K.A., J.M., S.P.S., M.S., J.L., G.D., C.E.C.A.H.); and Array BioPharma Inc., Boulder, Colorado (K.R., K.W.H., A.A.T.)
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Research ArticleArticle
PK-PD Modeling of BACE1 Inhibition
Xingrong Liu, Harvey Wong, Kimberly Scearce-Levie, Ryan J. Watts, Melis Coraggio, Young G. Shin, Kun Peng, Kristin R. Wildsmith, Jasvinder K. Atwal, Jason Mango, Stephen P. Schauer, Kelly Regal, Kevin W. Hunt, Allen A. Thomas, Michael Siu, Joseph Lyssikatos, Gauri Deshmukh and Cornelis E. C. A. Hop
Drug Metabolism and Disposition July 1, 2013, 41 (7) 1319-1328; DOI: https://doi.org/10.1124/dmd.112.050864
Research ArticleArticle
PK-PD Modeling of BACE1 Inhibition
Xingrong Liu, Harvey Wong, Kimberly Scearce-Levie, Ryan J. Watts, Melis Coraggio, Young G. Shin, Kun Peng, Kristin R. Wildsmith, Jasvinder K. Atwal, Jason Mango, Stephen P. Schauer, Kelly Regal, Kevin W. Hunt, Allen A. Thomas, Michael Siu, Joseph Lyssikatos, Gauri Deshmukh and Cornelis E. C. A. Hop
Drug Metabolism and Disposition July 1, 2013, 41 (7) 1319-1328; DOI: https://doi.org/10.1124/dmd.112.050864
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