Research ArticleArticle
Nanoparticle Formulation of a Poorly Soluble Cannabinoid Receptor 1 Antagonist Improves Absorption by Rat and Human Intestine
Sanna Siissalo, Hans de Waard, Marina H. de Jager, Rose Hayeshi, Henderik W. Frijlink, Wouter L.J. Hinrichs, Heike Dinter-Heidorn, Annie van Dam, Johannes H. Proost, Geny M.M. Groothuis and Inge A.M. de Graaf
Drug Metabolism and Disposition August 2013, 41 (8) 1557-1565; DOI: https://doi.org/10.1124/dmd.112.049585
Sanna Siissalo
Division of Pharmacokinetics, Toxicology, and Targeting (S.S., M.H.J., R.H., J.H.P., G.M.M.G., I.A.M.G.), and Division of Pharmaceutical Technology and Biopharmacy (H.W., H.W.F., W.L.J.H.), Department of Pharmacy, University of Groningen, Groningen, the Netherlands; Abbott Products GmbH, Hannover, Germany (H.D-H.); Mass Spectrometry Core Facility, University of Groningen, Groningen, the Netherlands (A.D.)
Hans de Waard
Division of Pharmacokinetics, Toxicology, and Targeting (S.S., M.H.J., R.H., J.H.P., G.M.M.G., I.A.M.G.), and Division of Pharmaceutical Technology and Biopharmacy (H.W., H.W.F., W.L.J.H.), Department of Pharmacy, University of Groningen, Groningen, the Netherlands; Abbott Products GmbH, Hannover, Germany (H.D-H.); Mass Spectrometry Core Facility, University of Groningen, Groningen, the Netherlands (A.D.)
Marina H. de Jager
Division of Pharmacokinetics, Toxicology, and Targeting (S.S., M.H.J., R.H., J.H.P., G.M.M.G., I.A.M.G.), and Division of Pharmaceutical Technology and Biopharmacy (H.W., H.W.F., W.L.J.H.), Department of Pharmacy, University of Groningen, Groningen, the Netherlands; Abbott Products GmbH, Hannover, Germany (H.D-H.); Mass Spectrometry Core Facility, University of Groningen, Groningen, the Netherlands (A.D.)
Rose Hayeshi
Division of Pharmacokinetics, Toxicology, and Targeting (S.S., M.H.J., R.H., J.H.P., G.M.M.G., I.A.M.G.), and Division of Pharmaceutical Technology and Biopharmacy (H.W., H.W.F., W.L.J.H.), Department of Pharmacy, University of Groningen, Groningen, the Netherlands; Abbott Products GmbH, Hannover, Germany (H.D-H.); Mass Spectrometry Core Facility, University of Groningen, Groningen, the Netherlands (A.D.)
Henderik W. Frijlink
Division of Pharmacokinetics, Toxicology, and Targeting (S.S., M.H.J., R.H., J.H.P., G.M.M.G., I.A.M.G.), and Division of Pharmaceutical Technology and Biopharmacy (H.W., H.W.F., W.L.J.H.), Department of Pharmacy, University of Groningen, Groningen, the Netherlands; Abbott Products GmbH, Hannover, Germany (H.D-H.); Mass Spectrometry Core Facility, University of Groningen, Groningen, the Netherlands (A.D.)
Wouter L.J. Hinrichs
Division of Pharmacokinetics, Toxicology, and Targeting (S.S., M.H.J., R.H., J.H.P., G.M.M.G., I.A.M.G.), and Division of Pharmaceutical Technology and Biopharmacy (H.W., H.W.F., W.L.J.H.), Department of Pharmacy, University of Groningen, Groningen, the Netherlands; Abbott Products GmbH, Hannover, Germany (H.D-H.); Mass Spectrometry Core Facility, University of Groningen, Groningen, the Netherlands (A.D.)
Heike Dinter-Heidorn
Division of Pharmacokinetics, Toxicology, and Targeting (S.S., M.H.J., R.H., J.H.P., G.M.M.G., I.A.M.G.), and Division of Pharmaceutical Technology and Biopharmacy (H.W., H.W.F., W.L.J.H.), Department of Pharmacy, University of Groningen, Groningen, the Netherlands; Abbott Products GmbH, Hannover, Germany (H.D-H.); Mass Spectrometry Core Facility, University of Groningen, Groningen, the Netherlands (A.D.)
Annie van Dam
Division of Pharmacokinetics, Toxicology, and Targeting (S.S., M.H.J., R.H., J.H.P., G.M.M.G., I.A.M.G.), and Division of Pharmaceutical Technology and Biopharmacy (H.W., H.W.F., W.L.J.H.), Department of Pharmacy, University of Groningen, Groningen, the Netherlands; Abbott Products GmbH, Hannover, Germany (H.D-H.); Mass Spectrometry Core Facility, University of Groningen, Groningen, the Netherlands (A.D.)
Johannes H. Proost
Division of Pharmacokinetics, Toxicology, and Targeting (S.S., M.H.J., R.H., J.H.P., G.M.M.G., I.A.M.G.), and Division of Pharmaceutical Technology and Biopharmacy (H.W., H.W.F., W.L.J.H.), Department of Pharmacy, University of Groningen, Groningen, the Netherlands; Abbott Products GmbH, Hannover, Germany (H.D-H.); Mass Spectrometry Core Facility, University of Groningen, Groningen, the Netherlands (A.D.)
Geny M.M. Groothuis
Division of Pharmacokinetics, Toxicology, and Targeting (S.S., M.H.J., R.H., J.H.P., G.M.M.G., I.A.M.G.), and Division of Pharmaceutical Technology and Biopharmacy (H.W., H.W.F., W.L.J.H.), Department of Pharmacy, University of Groningen, Groningen, the Netherlands; Abbott Products GmbH, Hannover, Germany (H.D-H.); Mass Spectrometry Core Facility, University of Groningen, Groningen, the Netherlands (A.D.)
Inge A.M. de Graaf
Division of Pharmacokinetics, Toxicology, and Targeting (S.S., M.H.J., R.H., J.H.P., G.M.M.G., I.A.M.G.), and Division of Pharmaceutical Technology and Biopharmacy (H.W., H.W.F., W.L.J.H.), Department of Pharmacy, University of Groningen, Groningen, the Netherlands; Abbott Products GmbH, Hannover, Germany (H.D-H.); Mass Spectrometry Core Facility, University of Groningen, Groningen, the Netherlands (A.D.)
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Research ArticleArticle
Nanoparticles of Poorly Soluble CB-1 Antagonist
Sanna Siissalo, Hans de Waard, Marina H. de Jager, Rose Hayeshi, Henderik W. Frijlink, Wouter L.J. Hinrichs, Heike Dinter-Heidorn, Annie van Dam, Johannes H. Proost, Geny M.M. Groothuis and Inge A.M. de Graaf
Drug Metabolism and Disposition August 1, 2013, 41 (8) 1557-1565; DOI: https://doi.org/10.1124/dmd.112.049585
Research ArticleArticle
Nanoparticles of Poorly Soluble CB-1 Antagonist
Sanna Siissalo, Hans de Waard, Marina H. de Jager, Rose Hayeshi, Henderik W. Frijlink, Wouter L.J. Hinrichs, Heike Dinter-Heidorn, Annie van Dam, Johannes H. Proost, Geny M.M. Groothuis and Inge A.M. de Graaf
Drug Metabolism and Disposition August 1, 2013, 41 (8) 1557-1565; DOI: https://doi.org/10.1124/dmd.112.049585
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