Research ArticleArticle
A Systematic Approach to Evaluate Herb-Drug Interaction Mechanisms: Investigation of Milk Thistle Extracts and Eight Isolated Constituents as CYP3A Inhibitors
Scott J. Brantley, Tyler N. Graf, Nicholas H. Oberlies and Mary F. Paine
Drug Metabolism and Disposition September 2013, 41 (9) 1662-1670; DOI: https://doi.org/10.1124/dmd.113.052563
Scott J. Brantley
Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (S.J.B., M.F.P.); and Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina (T.N.G., N.H.O.)
Tyler N. Graf
Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (S.J.B., M.F.P.); and Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina (T.N.G., N.H.O.)
Nicholas H. Oberlies
Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (S.J.B., M.F.P.); and Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina (T.N.G., N.H.O.)
Mary F. Paine
Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (S.J.B., M.F.P.); and Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina (T.N.G., N.H.O.)
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Milk Thistle Flavonolignans Inhibit CYP3A Activity
Scott J. Brantley, Tyler N. Graf, Nicholas H. Oberlies and Mary F. Paine
Drug Metabolism and Disposition September 1, 2013, 41 (9) 1662-1670; DOI: https://doi.org/10.1124/dmd.113.052563
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