Research ArticleArticle
Studies on the Role of Metabolic Activation in Tyrosine Kinase Inhibitor–Dependent Hepatotoxicity: Induction of CYP3A4 Enhances the Cytotoxicity of Lapatinib in HepaRG Cells
Klarissa D. Hardy, Michelle D. Wahlin, Ioannis Papageorgiou, Jashvant D. Unadkat, Allan E. Rettie and Sidney D. Nelson
Drug Metabolism and Disposition January 2014, 42 (1) 162-171; DOI: https://doi.org/10.1124/dmd.113.054817
Klarissa D. Hardy
Departments of Medicinal Chemistry (K.D.H., M.D.W., A.E.R, S.D.N.) and Pharmaceutics (I.P., J.D.U.), University of Washington School of Pharmacy, Seattle, Washington.
Michelle D. Wahlin
Departments of Medicinal Chemistry (K.D.H., M.D.W., A.E.R, S.D.N.) and Pharmaceutics (I.P., J.D.U.), University of Washington School of Pharmacy, Seattle, Washington.
Ioannis Papageorgiou
Departments of Medicinal Chemistry (K.D.H., M.D.W., A.E.R, S.D.N.) and Pharmaceutics (I.P., J.D.U.), University of Washington School of Pharmacy, Seattle, Washington.
Jashvant D. Unadkat
Departments of Medicinal Chemistry (K.D.H., M.D.W., A.E.R, S.D.N.) and Pharmaceutics (I.P., J.D.U.), University of Washington School of Pharmacy, Seattle, Washington.
Allan E. Rettie
Departments of Medicinal Chemistry (K.D.H., M.D.W., A.E.R, S.D.N.) and Pharmaceutics (I.P., J.D.U.), University of Washington School of Pharmacy, Seattle, Washington.
Sidney D. Nelson
Departments of Medicinal Chemistry (K.D.H., M.D.W., A.E.R, S.D.N.) and Pharmaceutics (I.P., J.D.U.), University of Washington School of Pharmacy, Seattle, Washington.
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Bioactivation and Cytotoxicity of Lapatinib
Klarissa D. Hardy, Michelle D. Wahlin, Ioannis Papageorgiou, Jashvant D. Unadkat, Allan E. Rettie and Sidney D. Nelson
Drug Metabolism and Disposition January 1, 2014, 42 (1) 162-171; DOI: https://doi.org/10.1124/dmd.113.054817
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