Research ArticleArticle
Paroxetine Markedly Increases Plasma Concentrations of Ophthalmic Timolol; CYP2D6 Inhibitors May Increase the Risk of Cardiovascular Adverse Effects of 0.5% Timolol Eye Drops
Jukka Mäenpää, Marjo Volotinen-Maja, Hannu Kautiainen, Mikko Neuvonen, Mikko Niemi, Pertti J. Neuvonen and Janne T. Backman
Drug Metabolism and Disposition December 2014, 42 (12) 2068-2076; DOI: https://doi.org/10.1124/dmd.114.059576
Jukka Mäenpää
Santen Oy, Tampere, Finland (J.M., M.V.-M.); Medcare Oy, Äänekoski, Finland (H.K.); and Department of Clinical Pharmacology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland (M.Ne., M.Ni., P.J.N., J.T.B.)
Marjo Volotinen-Maja
Santen Oy, Tampere, Finland (J.M., M.V.-M.); Medcare Oy, Äänekoski, Finland (H.K.); and Department of Clinical Pharmacology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland (M.Ne., M.Ni., P.J.N., J.T.B.)
Hannu Kautiainen
Santen Oy, Tampere, Finland (J.M., M.V.-M.); Medcare Oy, Äänekoski, Finland (H.K.); and Department of Clinical Pharmacology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland (M.Ne., M.Ni., P.J.N., J.T.B.)
Mikko Neuvonen
Santen Oy, Tampere, Finland (J.M., M.V.-M.); Medcare Oy, Äänekoski, Finland (H.K.); and Department of Clinical Pharmacology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland (M.Ne., M.Ni., P.J.N., J.T.B.)
Mikko Niemi
Santen Oy, Tampere, Finland (J.M., M.V.-M.); Medcare Oy, Äänekoski, Finland (H.K.); and Department of Clinical Pharmacology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland (M.Ne., M.Ni., P.J.N., J.T.B.)
Pertti J. Neuvonen
Santen Oy, Tampere, Finland (J.M., M.V.-M.); Medcare Oy, Äänekoski, Finland (H.K.); and Department of Clinical Pharmacology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland (M.Ne., M.Ni., P.J.N., J.T.B.)
Janne T. Backman
Santen Oy, Tampere, Finland (J.M., M.V.-M.); Medcare Oy, Äänekoski, Finland (H.K.); and Department of Clinical Pharmacology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland (M.Ne., M.Ni., P.J.N., J.T.B.)
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Research ArticleArticle
CYP2D6 Inhibition Raises Ophthalmic Timolol Concentrations
Jukka Mäenpää, Marjo Volotinen-Maja, Hannu Kautiainen, Mikko Neuvonen, Mikko Niemi, Pertti J. Neuvonen and Janne T. Backman
Drug Metabolism and Disposition December 1, 2014, 42 (12) 2068-2076; DOI: https://doi.org/10.1124/dmd.114.059576
Research ArticleArticle
CYP2D6 Inhibition Raises Ophthalmic Timolol Concentrations
Jukka Mäenpää, Marjo Volotinen-Maja, Hannu Kautiainen, Mikko Neuvonen, Mikko Niemi, Pertti J. Neuvonen and Janne T. Backman
Drug Metabolism and Disposition December 1, 2014, 42 (12) 2068-2076; DOI: https://doi.org/10.1124/dmd.114.059576
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