Research ArticleArticle
Elucidating the Mechanism of Cytochrome P450–Mediated Pyrimidine Ring Conversion to Pyrazole Metabolites with the BACE1 Inhibitor GNE-892 in Rats
Ryan Takahashi, Shuguang Ma, Alan Deese, Qin Yue, Heasook Kim-Kang, Yijun Yi, Michael Siu, Kevin W. Hunt, Nicholas C. Kallan, Cornelis E.C.A. Hop, Xingrong Liu and S. Cyrus Khojasteh
Drug Metabolism and Disposition May 2014, 42 (5) 890-898; DOI: https://doi.org/10.1124/dmd.114.057141
Ryan Takahashi
Departments of Drug Metabolism and Pharmacokinetics (R.T., S.M., Q.Y.,1 C.E.H., X.L., S.C.K), Small Molecule Pharmaceutical Sciences (A.D.), and Discovery Chemistry (M.S.), Genentech, Inc., South San Francisco, California; XenoBiotic Laboratories, Inc., Plainsboro, New Jersey (H.K., Y.Y.); and Array BioPharma, Boulder, Colorado (K.W.H., N.C.K.)
Shuguang Ma
Departments of Drug Metabolism and Pharmacokinetics (R.T., S.M., Q.Y.,1 C.E.H., X.L., S.C.K), Small Molecule Pharmaceutical Sciences (A.D.), and Discovery Chemistry (M.S.), Genentech, Inc., South San Francisco, California; XenoBiotic Laboratories, Inc., Plainsboro, New Jersey (H.K., Y.Y.); and Array BioPharma, Boulder, Colorado (K.W.H., N.C.K.)
Alan Deese
Departments of Drug Metabolism and Pharmacokinetics (R.T., S.M., Q.Y.,1 C.E.H., X.L., S.C.K), Small Molecule Pharmaceutical Sciences (A.D.), and Discovery Chemistry (M.S.), Genentech, Inc., South San Francisco, California; XenoBiotic Laboratories, Inc., Plainsboro, New Jersey (H.K., Y.Y.); and Array BioPharma, Boulder, Colorado (K.W.H., N.C.K.)
Qin Yue
Departments of Drug Metabolism and Pharmacokinetics (R.T., S.M., Q.Y.,1 C.E.H., X.L., S.C.K), Small Molecule Pharmaceutical Sciences (A.D.), and Discovery Chemistry (M.S.), Genentech, Inc., South San Francisco, California; XenoBiotic Laboratories, Inc., Plainsboro, New Jersey (H.K., Y.Y.); and Array BioPharma, Boulder, Colorado (K.W.H., N.C.K.)
Heasook Kim-Kang
Departments of Drug Metabolism and Pharmacokinetics (R.T., S.M., Q.Y.,1 C.E.H., X.L., S.C.K), Small Molecule Pharmaceutical Sciences (A.D.), and Discovery Chemistry (M.S.), Genentech, Inc., South San Francisco, California; XenoBiotic Laboratories, Inc., Plainsboro, New Jersey (H.K., Y.Y.); and Array BioPharma, Boulder, Colorado (K.W.H., N.C.K.)
Yijun Yi
Departments of Drug Metabolism and Pharmacokinetics (R.T., S.M., Q.Y.,1 C.E.H., X.L., S.C.K), Small Molecule Pharmaceutical Sciences (A.D.), and Discovery Chemistry (M.S.), Genentech, Inc., South San Francisco, California; XenoBiotic Laboratories, Inc., Plainsboro, New Jersey (H.K., Y.Y.); and Array BioPharma, Boulder, Colorado (K.W.H., N.C.K.)
Michael Siu
Departments of Drug Metabolism and Pharmacokinetics (R.T., S.M., Q.Y.,1 C.E.H., X.L., S.C.K), Small Molecule Pharmaceutical Sciences (A.D.), and Discovery Chemistry (M.S.), Genentech, Inc., South San Francisco, California; XenoBiotic Laboratories, Inc., Plainsboro, New Jersey (H.K., Y.Y.); and Array BioPharma, Boulder, Colorado (K.W.H., N.C.K.)
Kevin W. Hunt
Departments of Drug Metabolism and Pharmacokinetics (R.T., S.M., Q.Y.,1 C.E.H., X.L., S.C.K), Small Molecule Pharmaceutical Sciences (A.D.), and Discovery Chemistry (M.S.), Genentech, Inc., South San Francisco, California; XenoBiotic Laboratories, Inc., Plainsboro, New Jersey (H.K., Y.Y.); and Array BioPharma, Boulder, Colorado (K.W.H., N.C.K.)
Nicholas C. Kallan
Departments of Drug Metabolism and Pharmacokinetics (R.T., S.M., Q.Y.,1 C.E.H., X.L., S.C.K), Small Molecule Pharmaceutical Sciences (A.D.), and Discovery Chemistry (M.S.), Genentech, Inc., South San Francisco, California; XenoBiotic Laboratories, Inc., Plainsboro, New Jersey (H.K., Y.Y.); and Array BioPharma, Boulder, Colorado (K.W.H., N.C.K.)
Cornelis E.C.A. Hop
Departments of Drug Metabolism and Pharmacokinetics (R.T., S.M., Q.Y.,1 C.E.H., X.L., S.C.K), Small Molecule Pharmaceutical Sciences (A.D.), and Discovery Chemistry (M.S.), Genentech, Inc., South San Francisco, California; XenoBiotic Laboratories, Inc., Plainsboro, New Jersey (H.K., Y.Y.); and Array BioPharma, Boulder, Colorado (K.W.H., N.C.K.)
Xingrong Liu
Departments of Drug Metabolism and Pharmacokinetics (R.T., S.M., Q.Y.,1 C.E.H., X.L., S.C.K), Small Molecule Pharmaceutical Sciences (A.D.), and Discovery Chemistry (M.S.), Genentech, Inc., South San Francisco, California; XenoBiotic Laboratories, Inc., Plainsboro, New Jersey (H.K., Y.Y.); and Array BioPharma, Boulder, Colorado (K.W.H., N.C.K.)
S. Cyrus Khojasteh
Departments of Drug Metabolism and Pharmacokinetics (R.T., S.M., Q.Y.,1 C.E.H., X.L., S.C.K), Small Molecule Pharmaceutical Sciences (A.D.), and Discovery Chemistry (M.S.), Genentech, Inc., South San Francisco, California; XenoBiotic Laboratories, Inc., Plainsboro, New Jersey (H.K., Y.Y.); and Array BioPharma, Boulder, Colorado (K.W.H., N.C.K.)
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Research ArticleArticle
Metabolic Conversion of Pyrimidine to Pyrazole by P450
Ryan Takahashi, Shuguang Ma, Alan Deese, Qin Yue, Heasook Kim-Kang, Yijun Yi, Michael Siu, Kevin W. Hunt, Nicholas C. Kallan, Cornelis E.C.A. Hop, Xingrong Liu and S. Cyrus Khojasteh
Drug Metabolism and Disposition May 1, 2014, 42 (5) 890-898; DOI: https://doi.org/10.1124/dmd.114.057141
Research ArticleArticle
Metabolic Conversion of Pyrimidine to Pyrazole by P450
Ryan Takahashi, Shuguang Ma, Alan Deese, Qin Yue, Heasook Kim-Kang, Yijun Yi, Michael Siu, Kevin W. Hunt, Nicholas C. Kallan, Cornelis E.C.A. Hop, Xingrong Liu and S. Cyrus Khojasteh
Drug Metabolism and Disposition May 1, 2014, 42 (5) 890-898; DOI: https://doi.org/10.1124/dmd.114.057141
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