Research ArticleArticle
Quantitative Investigation of the Brain-to-Cerebrospinal Fluid Unbound Drug Concentration Ratio under Steady-State Conditions in Rats Using a Pharmacokinetic Model and Scaling Factors for Active Efflux Transporters
Hiroshi Kodaira, Hiroyuki Kusuhara, Eiichi Fuse, Junko Ushiki and Yuichi Sugiyama
Drug Metabolism and Disposition June 2014, 42 (6) 983-989; DOI: https://doi.org/10.1124/dmd.113.056606
Hiroshi Kodaira
Graduate School of Pharmaceutical Sciences, the University of Tokyo, Tokyo (H.Ko., H.Ku.); Pharmacokinetic Research Laboratories, Research Division, Kyowa Hakko Kirin Co., Ltd., Shizuoka (H.Ko., E.F., J.U.); and Sugiyama Laboratory, RIKEN Innovation Center, RIKEN Research Cluster for Innovation, RIKEN (Y.S.), Kanagawa, Japan
Hiroyuki Kusuhara
Graduate School of Pharmaceutical Sciences, the University of Tokyo, Tokyo (H.Ko., H.Ku.); Pharmacokinetic Research Laboratories, Research Division, Kyowa Hakko Kirin Co., Ltd., Shizuoka (H.Ko., E.F., J.U.); and Sugiyama Laboratory, RIKEN Innovation Center, RIKEN Research Cluster for Innovation, RIKEN (Y.S.), Kanagawa, Japan
Eiichi Fuse
Graduate School of Pharmaceutical Sciences, the University of Tokyo, Tokyo (H.Ko., H.Ku.); Pharmacokinetic Research Laboratories, Research Division, Kyowa Hakko Kirin Co., Ltd., Shizuoka (H.Ko., E.F., J.U.); and Sugiyama Laboratory, RIKEN Innovation Center, RIKEN Research Cluster for Innovation, RIKEN (Y.S.), Kanagawa, Japan
Junko Ushiki
Graduate School of Pharmaceutical Sciences, the University of Tokyo, Tokyo (H.Ko., H.Ku.); Pharmacokinetic Research Laboratories, Research Division, Kyowa Hakko Kirin Co., Ltd., Shizuoka (H.Ko., E.F., J.U.); and Sugiyama Laboratory, RIKEN Innovation Center, RIKEN Research Cluster for Innovation, RIKEN (Y.S.), Kanagawa, Japan
Yuichi Sugiyama
Graduate School of Pharmaceutical Sciences, the University of Tokyo, Tokyo (H.Ko., H.Ku.); Pharmacokinetic Research Laboratories, Research Division, Kyowa Hakko Kirin Co., Ltd., Shizuoka (H.Ko., E.F., J.U.); and Sugiyama Laboratory, RIKEN Innovation Center, RIKEN Research Cluster for Innovation, RIKEN (Y.S.), Kanagawa, Japan
Submit a Response to This Article
Jump to comment:
No eLetters have been published for this article.
In this issue
Research ArticleArticle
Pharmacokinetic Model for Drug Disposition in the Brain
Hiroshi Kodaira, Hiroyuki Kusuhara, Eiichi Fuse, Junko Ushiki and Yuichi Sugiyama
Drug Metabolism and Disposition June 1, 2014, 42 (6) 983-989; DOI: https://doi.org/10.1124/dmd.113.056606
Jump to section
Related Articles
Cited By...
More in this TOC Section
Similar Articles
Advertisement