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Elucidating the Mechanisms of Formation for Two Unusual Cytochrome P450–Mediated Fused Ring Metabolites of GDC-0623, a MAPK/ERK Kinase Inhibitor
Ryan H. Takahashi, Shuguang Ma, Sarah J. Robinson, Qin Yue, Edna F. Choo and S. Cyrus Khojasteh
Drug Metabolism and Disposition December 2015, 43 (12) 1929-1933; DOI: https://doi.org/10.1124/dmd.115.067181
Ryan H. Takahashi
Departments of Drug Metabolism and Pharmacokinetics (R.H.T., S.M., Q.Y., E.F.C., S.C.K.) and Small Molecule Pharmaceutical Sciences (S.J.R.), Genentech, Inc., South San Francisco, California
Shuguang Ma
Departments of Drug Metabolism and Pharmacokinetics (R.H.T., S.M., Q.Y., E.F.C., S.C.K.) and Small Molecule Pharmaceutical Sciences (S.J.R.), Genentech, Inc., South San Francisco, California
Sarah J. Robinson
Departments of Drug Metabolism and Pharmacokinetics (R.H.T., S.M., Q.Y., E.F.C., S.C.K.) and Small Molecule Pharmaceutical Sciences (S.J.R.), Genentech, Inc., South San Francisco, California
Qin Yue
Departments of Drug Metabolism and Pharmacokinetics (R.H.T., S.M., Q.Y., E.F.C., S.C.K.) and Small Molecule Pharmaceutical Sciences (S.J.R.), Genentech, Inc., South San Francisco, California
Edna F. Choo
Departments of Drug Metabolism and Pharmacokinetics (R.H.T., S.M., Q.Y., E.F.C., S.C.K.) and Small Molecule Pharmaceutical Sciences (S.J.R.), Genentech, Inc., South San Francisco, California
S. Cyrus Khojasteh
Departments of Drug Metabolism and Pharmacokinetics (R.H.T., S.M., Q.Y., E.F.C., S.C.K.) and Small Molecule Pharmaceutical Sciences (S.J.R.), Genentech, Inc., South San Francisco, California
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Rapid CommunicationShort Communication
Unusual Biotransformations of GDC-0623 by P450
Ryan H. Takahashi, Shuguang Ma, Sarah J. Robinson, Qin Yue, Edna F. Choo and S. Cyrus Khojasteh
Drug Metabolism and Disposition December 1, 2015, 43 (12) 1929-1933; DOI: https://doi.org/10.1124/dmd.115.067181
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