Research ArticleArticle
Characterization of Phase I Metabolism of Resibufogenin and Evaluation of the Metabolic Effects on Its Antitumor Activity and Toxicity
Jing Ning, Zhen-Long Yu, Liang-Hai Hu, Chao Wang, Xiao-Kui Huo, Sa Deng, Jie Hou, Jing-Jing Wu, Guang-Bo Ge, Xiao-Chi Ma and Ling Yang
Drug Metabolism and Disposition March 2015, 43 (3) 299-308; DOI: https://doi.org/10.1124/dmd.114.060996
Jing Ning
Research Institute of Integrated Traditional and Western Medicine, College of Pharmacy, Dalian Medical University, Dalian, China (J.N., Z.-L.Y., C.W., X.-K H., S.D., J.H., X.-C.M.); Key Laboratory for Molecular Enzymology and Engineering, the Ministry of Education, Jilin University, Changchun, China (L.-H., H); Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China (J.N., J.-J.W., G.-B.G., L.Y.); State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (C.W.)
Zhen-Long Yu
Research Institute of Integrated Traditional and Western Medicine, College of Pharmacy, Dalian Medical University, Dalian, China (J.N., Z.-L.Y., C.W., X.-K H., S.D., J.H., X.-C.M.); Key Laboratory for Molecular Enzymology and Engineering, the Ministry of Education, Jilin University, Changchun, China (L.-H., H); Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China (J.N., J.-J.W., G.-B.G., L.Y.); State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (C.W.)
Liang-Hai Hu
Research Institute of Integrated Traditional and Western Medicine, College of Pharmacy, Dalian Medical University, Dalian, China (J.N., Z.-L.Y., C.W., X.-K H., S.D., J.H., X.-C.M.); Key Laboratory for Molecular Enzymology and Engineering, the Ministry of Education, Jilin University, Changchun, China (L.-H., H); Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China (J.N., J.-J.W., G.-B.G., L.Y.); State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (C.W.)
Chao Wang
Research Institute of Integrated Traditional and Western Medicine, College of Pharmacy, Dalian Medical University, Dalian, China (J.N., Z.-L.Y., C.W., X.-K H., S.D., J.H., X.-C.M.); Key Laboratory for Molecular Enzymology and Engineering, the Ministry of Education, Jilin University, Changchun, China (L.-H., H); Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China (J.N., J.-J.W., G.-B.G., L.Y.); State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (C.W.)
Xiao-Kui Huo
Research Institute of Integrated Traditional and Western Medicine, College of Pharmacy, Dalian Medical University, Dalian, China (J.N., Z.-L.Y., C.W., X.-K H., S.D., J.H., X.-C.M.); Key Laboratory for Molecular Enzymology and Engineering, the Ministry of Education, Jilin University, Changchun, China (L.-H., H); Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China (J.N., J.-J.W., G.-B.G., L.Y.); State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (C.W.)
Sa Deng
Research Institute of Integrated Traditional and Western Medicine, College of Pharmacy, Dalian Medical University, Dalian, China (J.N., Z.-L.Y., C.W., X.-K H., S.D., J.H., X.-C.M.); Key Laboratory for Molecular Enzymology and Engineering, the Ministry of Education, Jilin University, Changchun, China (L.-H., H); Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China (J.N., J.-J.W., G.-B.G., L.Y.); State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (C.W.)
Jie Hou
Research Institute of Integrated Traditional and Western Medicine, College of Pharmacy, Dalian Medical University, Dalian, China (J.N., Z.-L.Y., C.W., X.-K H., S.D., J.H., X.-C.M.); Key Laboratory for Molecular Enzymology and Engineering, the Ministry of Education, Jilin University, Changchun, China (L.-H., H); Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China (J.N., J.-J.W., G.-B.G., L.Y.); State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (C.W.)
Jing-Jing Wu
Research Institute of Integrated Traditional and Western Medicine, College of Pharmacy, Dalian Medical University, Dalian, China (J.N., Z.-L.Y., C.W., X.-K H., S.D., J.H., X.-C.M.); Key Laboratory for Molecular Enzymology and Engineering, the Ministry of Education, Jilin University, Changchun, China (L.-H., H); Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China (J.N., J.-J.W., G.-B.G., L.Y.); State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (C.W.)
Guang-Bo Ge
Research Institute of Integrated Traditional and Western Medicine, College of Pharmacy, Dalian Medical University, Dalian, China (J.N., Z.-L.Y., C.W., X.-K H., S.D., J.H., X.-C.M.); Key Laboratory for Molecular Enzymology and Engineering, the Ministry of Education, Jilin University, Changchun, China (L.-H., H); Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China (J.N., J.-J.W., G.-B.G., L.Y.); State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (C.W.)
Xiao-Chi Ma
Research Institute of Integrated Traditional and Western Medicine, College of Pharmacy, Dalian Medical University, Dalian, China (J.N., Z.-L.Y., C.W., X.-K H., S.D., J.H., X.-C.M.); Key Laboratory for Molecular Enzymology and Engineering, the Ministry of Education, Jilin University, Changchun, China (L.-H., H); Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China (J.N., J.-J.W., G.-B.G., L.Y.); State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (C.W.)
Ling Yang
Research Institute of Integrated Traditional and Western Medicine, College of Pharmacy, Dalian Medical University, Dalian, China (J.N., Z.-L.Y., C.W., X.-K H., S.D., J.H., X.-C.M.); Key Laboratory for Molecular Enzymology and Engineering, the Ministry of Education, Jilin University, Changchun, China (L.-H., H); Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China (J.N., J.-J.W., G.-B.G., L.Y.); State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (C.W.)
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Metabolism of RB and Its Effects on Anticancer Activity
Jing Ning, Zhen-Long Yu, Liang-Hai Hu, Chao Wang, Xiao-Kui Huo, Sa Deng, Jie Hou, Jing-Jing Wu, Guang-Bo Ge, Xiao-Chi Ma and Ling Yang
Drug Metabolism and Disposition March 1, 2015, 43 (3) 299-308; DOI: https://doi.org/10.1124/dmd.114.060996
Research ArticleArticle
Metabolism of RB and Its Effects on Anticancer Activity
Jing Ning, Zhen-Long Yu, Liang-Hai Hu, Chao Wang, Xiao-Kui Huo, Sa Deng, Jie Hou, Jing-Jing Wu, Guang-Bo Ge, Xiao-Chi Ma and Ling Yang
Drug Metabolism and Disposition March 1, 2015, 43 (3) 299-308; DOI: https://doi.org/10.1124/dmd.114.060996
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