Research ArticleMinireview
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Trimethylamine and Trimethylamine N-Oxide, a Flavin-Containing Monooxygenase 3 (FMO3)-Mediated Host-Microbiome Metabolic Axis Implicated in Health and Disease
Diede Fennema, Ian R. Phillips and Elizabeth A. Shephard
Drug Metabolism and Disposition November 2016, 44 (11) 1839-1850; DOI: https://doi.org/10.1124/dmd.116.070615
Diede Fennema
Institute of Structural and Molecular Biology, University College London (D.F., I.R.P., E.A.S.), and School of Biological and Chemical Sciences, Queen Mary University of London (I.R.P.), London, United Kingdom
Ian R. Phillips
Institute of Structural and Molecular Biology, University College London (D.F., I.R.P., E.A.S.), and School of Biological and Chemical Sciences, Queen Mary University of London (I.R.P.), London, United Kingdom
Elizabeth A. Shephard
Institute of Structural and Molecular Biology, University College London (D.F., I.R.P., E.A.S.), and School of Biological and Chemical Sciences, Queen Mary University of London (I.R.P.), London, United Kingdom
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In this issue
Research ArticleMinireview
TMA/TMAO, an FMO3-Mediated Host-Microbiome Metabolic Axis
Diede Fennema, Ian R. Phillips and Elizabeth A. Shephard
Drug Metabolism and Disposition November 1, 2016, 44 (11) 1839-1850; DOI: https://doi.org/10.1124/dmd.116.070615
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- Article
- Abstract
- Introduction
- Origins and Metabolic Fate of TMA
- TMAU, a Deficiency of FMO3
- Dietary Precursors of TMA and the Bacteria Involved in its Production in the Gut
- Metabolism of TMA by Gut Bacteria
- Oral and Vaginal Microbiota
- Noncommensal Bacteria Able to Produce TMA
- TMA/TMAO Host-Microbiome Metabolic Axis in Health and Disease
- Conclusions
- Authorship Contributions
- Footnotes
- Abbreviations
- References
- Figures & Data
- Info & Metrics
- eLetters
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