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Research ArticleArticle

Application of a Micropatterned Cocultured Hepatocyte System To Predict Preclinical and Human-Specific Drug Metabolism

T. Eric Ballard, Shuai Wang, Loretta M. Cox, Mark A. Moen, Stacy Krzyzewski, Okechukwu Ukairo and R. Scott Obach
Drug Metabolism and Disposition February 2016, 44 (2) 172-179; DOI: https://doi.org/10.1124/dmd.115.066688
T. Eric Ballard
Pharmacokinetics, Dynamics and Metabolism, Pfizer, Inc., Groton, Connecticut (T.E.B., S.W., L.M.C., M.A.M., R.S.O.); Hepregen Corporation, Medford, Massachusetts (S.K., O.U.),
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Shuai Wang
Pharmacokinetics, Dynamics and Metabolism, Pfizer, Inc., Groton, Connecticut (T.E.B., S.W., L.M.C., M.A.M., R.S.O.); Hepregen Corporation, Medford, Massachusetts (S.K., O.U.),
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Loretta M. Cox
Pharmacokinetics, Dynamics and Metabolism, Pfizer, Inc., Groton, Connecticut (T.E.B., S.W., L.M.C., M.A.M., R.S.O.); Hepregen Corporation, Medford, Massachusetts (S.K., O.U.),
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Mark A. Moen
Pharmacokinetics, Dynamics and Metabolism, Pfizer, Inc., Groton, Connecticut (T.E.B., S.W., L.M.C., M.A.M., R.S.O.); Hepregen Corporation, Medford, Massachusetts (S.K., O.U.),
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Stacy Krzyzewski
Pharmacokinetics, Dynamics and Metabolism, Pfizer, Inc., Groton, Connecticut (T.E.B., S.W., L.M.C., M.A.M., R.S.O.); Hepregen Corporation, Medford, Massachusetts (S.K., O.U.),
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Okechukwu Ukairo
Pharmacokinetics, Dynamics and Metabolism, Pfizer, Inc., Groton, Connecticut (T.E.B., S.W., L.M.C., M.A.M., R.S.O.); Hepregen Corporation, Medford, Massachusetts (S.K., O.U.),
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R. Scott Obach
Pharmacokinetics, Dynamics and Metabolism, Pfizer, Inc., Groton, Connecticut (T.E.B., S.W., L.M.C., M.A.M., R.S.O.); Hepregen Corporation, Medford, Massachusetts (S.K., O.U.),
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Article Information

vol. 44 no. 2 172-179
DOI 
https://doi.org/10.1124/dmd.115.066688
PubMed 
26608083

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received August 17, 2015
  • Accepted November 19, 2015
  • Published online January 7, 2016.

Article Versions

  • Earlier version (November 25, 2015 - 06:05).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2016 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. T. Eric Ballard,
  2. Shuai Wang1,
  3. Loretta M. Cox,
  4. Mark A. Moen,
  5. Stacy Krzyzewski,
  6. Okechukwu Ukairo2, and
  7. R. Scott Obach
  1. Pharmacokinetics, Dynamics and Metabolism, Pfizer, Inc., Groton, Connecticut (T.E.B., S.W., L.M.C., M.A.M., R.S.O.); Hepregen Corporation, Medford, Massachusetts (S.K., O.U.),
  1. Address correspondence to:
    Dr. T. Eric Ballard, Pharmacokinetics, Dynamics and Metabolism, Pfizer, Inc., Groton, CT 06340. E-mail: Thomas.E.Ballard{at}Pfizer.com
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Drug Metabolism and Disposition: 44 (2)
Drug Metabolism and Disposition
Vol. 44, Issue 2
1 Feb 2016
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Research ArticleArticle

Multispecies MPCC Metabolite Profiling

T. Eric Ballard, Shuai Wang, Loretta M. Cox, Mark A. Moen, Stacy Krzyzewski, Okechukwu Ukairo and R. Scott Obach
Drug Metabolism and Disposition February 1, 2016, 44 (2) 172-179; DOI: https://doi.org/10.1124/dmd.115.066688

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Research ArticleArticle

Multispecies MPCC Metabolite Profiling

T. Eric Ballard, Shuai Wang, Loretta M. Cox, Mark A. Moen, Stacy Krzyzewski, Okechukwu Ukairo and R. Scott Obach
Drug Metabolism and Disposition February 1, 2016, 44 (2) 172-179; DOI: https://doi.org/10.1124/dmd.115.066688
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