Research ArticleArticle
SGLT-1 Transport and Deglycosylation inside Intestinal Cells Are Key Steps in the Absorption and Disposition of Calycosin-7-O-β-d-Glucoside in Rats
Jian Shi, Haihui Zheng, Jia Yu, Lijun Zhu, Tongmeng Yan, Peng Wu, Linlin Lu, Ying Wang, Ming Hu and Zhongqiu Liu
Drug Metabolism and Disposition March 2016, 44 (3) 283-296; DOI: https://doi.org/10.1124/dmd.115.067009
Jian Shi
Department of Pharmaceutics, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, PR China (J.S., T.M.Y., Z.Q.L); International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, PR China (J.S., H.H.Z., J.Y., L.J.Z., T.M.Y., P.W., L.L.L., Y.W., M.H., Z.Q.L.); and Department of Pharmacological and Pharmaceutical Science, College of Pharmacy, University of Houston, Houston, Texas (M.H.)
Haihui Zheng
Department of Pharmaceutics, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, PR China (J.S., T.M.Y., Z.Q.L); International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, PR China (J.S., H.H.Z., J.Y., L.J.Z., T.M.Y., P.W., L.L.L., Y.W., M.H., Z.Q.L.); and Department of Pharmacological and Pharmaceutical Science, College of Pharmacy, University of Houston, Houston, Texas (M.H.)
Jia Yu
Department of Pharmaceutics, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, PR China (J.S., T.M.Y., Z.Q.L); International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, PR China (J.S., H.H.Z., J.Y., L.J.Z., T.M.Y., P.W., L.L.L., Y.W., M.H., Z.Q.L.); and Department of Pharmacological and Pharmaceutical Science, College of Pharmacy, University of Houston, Houston, Texas (M.H.)
Lijun Zhu
Department of Pharmaceutics, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, PR China (J.S., T.M.Y., Z.Q.L); International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, PR China (J.S., H.H.Z., J.Y., L.J.Z., T.M.Y., P.W., L.L.L., Y.W., M.H., Z.Q.L.); and Department of Pharmacological and Pharmaceutical Science, College of Pharmacy, University of Houston, Houston, Texas (M.H.)
Tongmeng Yan
Department of Pharmaceutics, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, PR China (J.S., T.M.Y., Z.Q.L); International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, PR China (J.S., H.H.Z., J.Y., L.J.Z., T.M.Y., P.W., L.L.L., Y.W., M.H., Z.Q.L.); and Department of Pharmacological and Pharmaceutical Science, College of Pharmacy, University of Houston, Houston, Texas (M.H.)
Peng Wu
Department of Pharmaceutics, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, PR China (J.S., T.M.Y., Z.Q.L); International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, PR China (J.S., H.H.Z., J.Y., L.J.Z., T.M.Y., P.W., L.L.L., Y.W., M.H., Z.Q.L.); and Department of Pharmacological and Pharmaceutical Science, College of Pharmacy, University of Houston, Houston, Texas (M.H.)
Linlin Lu
Department of Pharmaceutics, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, PR China (J.S., T.M.Y., Z.Q.L); International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, PR China (J.S., H.H.Z., J.Y., L.J.Z., T.M.Y., P.W., L.L.L., Y.W., M.H., Z.Q.L.); and Department of Pharmacological and Pharmaceutical Science, College of Pharmacy, University of Houston, Houston, Texas (M.H.)
Ying Wang
Department of Pharmaceutics, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, PR China (J.S., T.M.Y., Z.Q.L); International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, PR China (J.S., H.H.Z., J.Y., L.J.Z., T.M.Y., P.W., L.L.L., Y.W., M.H., Z.Q.L.); and Department of Pharmacological and Pharmaceutical Science, College of Pharmacy, University of Houston, Houston, Texas (M.H.)
Ming Hu
Department of Pharmaceutics, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, PR China (J.S., T.M.Y., Z.Q.L); International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, PR China (J.S., H.H.Z., J.Y., L.J.Z., T.M.Y., P.W., L.L.L., Y.W., M.H., Z.Q.L.); and Department of Pharmacological and Pharmaceutical Science, College of Pharmacy, University of Houston, Houston, Texas (M.H.)
Zhongqiu Liu
Department of Pharmaceutics, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, PR China (J.S., T.M.Y., Z.Q.L); International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, PR China (J.S., H.H.Z., J.Y., L.J.Z., T.M.Y., P.W., L.L.L., Y.W., M.H., Z.Q.L.); and Department of Pharmacological and Pharmaceutical Science, College of Pharmacy, University of Houston, Houston, Texas (M.H.)
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Research ArticleArticle
Transport of Calycosin-7-O-β-d-Glucoside by SGLT-1 in Rats
Jian Shi, Haihui Zheng, Jia Yu, Lijun Zhu, Tongmeng Yan, Peng Wu, Linlin Lu, Ying Wang, Ming Hu and Zhongqiu Liu
Drug Metabolism and Disposition March 1, 2016, 44 (3) 283-296; DOI: https://doi.org/10.1124/dmd.115.067009
Research ArticleArticle
Transport of Calycosin-7-O-β-d-Glucoside by SGLT-1 in Rats
Jian Shi, Haihui Zheng, Jia Yu, Lijun Zhu, Tongmeng Yan, Peng Wu, Linlin Lu, Ying Wang, Ming Hu and Zhongqiu Liu
Drug Metabolism and Disposition March 1, 2016, 44 (3) 283-296; DOI: https://doi.org/10.1124/dmd.115.067009
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