Research ArticleArticle
Rapid Method To Determine Intracellular Drug Concentrations in Cellular Uptake Assays: Application to Metformin in Organic Cation Transporter 1–Transfected Human Embryonic Kidney 293 Cells
Huan-Chieh Chien, Arik A. Zur, Tristan S. Maurer, Sook Wah Yee, John Tolsma, Paul Jasper, Dennis O. Scott and Kathleen M. Giacomini
Drug Metabolism and Disposition March 2016, 44 (3) 356-364; DOI: https://doi.org/10.1124/dmd.115.066647
Huan-Chieh Chien
Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California San Francisco, San Francisco, California (H.C.C., A.A.Z., S.W.Y., K.M.G.); Systems Modeling and Simulation (T.S.M.) and Cardiovascular and Metabolic Disease Research Unit (D.O.S.), Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Cambridge, Massachusetts; RES Group, Inc. (J.T., P.J.) Needham, Massachusetts
Arik A. Zur
Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California San Francisco, San Francisco, California (H.C.C., A.A.Z., S.W.Y., K.M.G.); Systems Modeling and Simulation (T.S.M.) and Cardiovascular and Metabolic Disease Research Unit (D.O.S.), Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Cambridge, Massachusetts; RES Group, Inc. (J.T., P.J.) Needham, Massachusetts
Tristan S. Maurer
Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California San Francisco, San Francisco, California (H.C.C., A.A.Z., S.W.Y., K.M.G.); Systems Modeling and Simulation (T.S.M.) and Cardiovascular and Metabolic Disease Research Unit (D.O.S.), Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Cambridge, Massachusetts; RES Group, Inc. (J.T., P.J.) Needham, Massachusetts
Sook Wah Yee
Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California San Francisco, San Francisco, California (H.C.C., A.A.Z., S.W.Y., K.M.G.); Systems Modeling and Simulation (T.S.M.) and Cardiovascular and Metabolic Disease Research Unit (D.O.S.), Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Cambridge, Massachusetts; RES Group, Inc. (J.T., P.J.) Needham, Massachusetts
John Tolsma
Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California San Francisco, San Francisco, California (H.C.C., A.A.Z., S.W.Y., K.M.G.); Systems Modeling and Simulation (T.S.M.) and Cardiovascular and Metabolic Disease Research Unit (D.O.S.), Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Cambridge, Massachusetts; RES Group, Inc. (J.T., P.J.) Needham, Massachusetts
Paul Jasper
Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California San Francisco, San Francisco, California (H.C.C., A.A.Z., S.W.Y., K.M.G.); Systems Modeling and Simulation (T.S.M.) and Cardiovascular and Metabolic Disease Research Unit (D.O.S.), Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Cambridge, Massachusetts; RES Group, Inc. (J.T., P.J.) Needham, Massachusetts
Dennis O. Scott
Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California San Francisco, San Francisco, California (H.C.C., A.A.Z., S.W.Y., K.M.G.); Systems Modeling and Simulation (T.S.M.) and Cardiovascular and Metabolic Disease Research Unit (D.O.S.), Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Cambridge, Massachusetts; RES Group, Inc. (J.T., P.J.) Needham, Massachusetts
Kathleen M. Giacomini
Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California San Francisco, San Francisco, California (H.C.C., A.A.Z., S.W.Y., K.M.G.); Systems Modeling and Simulation (T.S.M.) and Cardiovascular and Metabolic Disease Research Unit (D.O.S.), Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Cambridge, Massachusetts; RES Group, Inc. (J.T., P.J.) Needham, Massachusetts
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Research ArticleArticle
Rapid Method to Determine Intracellular Concentrations
Huan-Chieh Chien, Arik A. Zur, Tristan S. Maurer, Sook Wah Yee, John Tolsma, Paul Jasper, Dennis O. Scott and Kathleen M. Giacomini
Drug Metabolism and Disposition March 1, 2016, 44 (3) 356-364; DOI: https://doi.org/10.1124/dmd.115.066647
Research ArticleArticle
Rapid Method to Determine Intracellular Concentrations
Huan-Chieh Chien, Arik A. Zur, Tristan S. Maurer, Sook Wah Yee, John Tolsma, Paul Jasper, Dennis O. Scott and Kathleen M. Giacomini
Drug Metabolism and Disposition March 1, 2016, 44 (3) 356-364; DOI: https://doi.org/10.1124/dmd.115.066647
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