Article Figures & Data
Figures
- Fig. 1.
Representative Western blot analysis of OATP1B1 and OAT1B3 in pediatric liver specimens. Lane 1, positive control for OATP1B3; lane 2, molecular ladder; lane 3, positive control for OATP1B1; lanes 4–6, pediatric liver specimens.
- Fig. 2.
Relative OATP1B protein expression (normalized to GAPDH) in pediatric liver for different age groups (group A, <3 months; group B, 3 months to <2 years; group C, 2 to <6 years; group D, 6–12 years), as follows: highly glycosylated OATP1B3 (A); core-glycosylated OATP1B3 (B); total (highly glycosylated and core-glycosylated) OATP1B3 (C); and OATP1B1 (D). Boxes represent the interquartile range, whiskers represent the 10th and 90th percentiles. The solid horizontal line in the box denotes the median, and the dotted line represents the mean of the data.
- Fig. 3.
Relative OATP1B protein expression (normalized to GAPDH) in pediatric liver versus postnatal age. The x-axis is discontinuous, with ages less than 1 year shown as a fraction. Highly glycosylated OATP1B3 (A), core-glycosylated OATP1B3 (B), total (highly glycosylated and core-glycosylated) OATP1B3 (C), and OATP1B1 (D).
Tables
Demographic Information Values Postnatal Age (N) 80 Age Range 9 days – 12 yr Mean Age (SD) 3.53 yr (3.86 yr) Sex (N) Male 43 Female 27 Unknown 10 Race (N) Caucasian 43 African-American 20 Other 5 Unknown 12 Source (N) Living Donor 32 Post Mortem 48 - TABLE 2
Relative OATP1B protein expression in different age groups investigated in this study
Age Groups A B C D Postnatal Age Range <3 mo 3 mo to <2 yr 2 to <6 yr 6–12 yr N 20 21 17 22 Mean age (yr) 0.128 0.715 3.73 9.14 S.D. (yr) 0.067 0.412 1.13 1.67 Highly Glycosylated OATP1B3 Geometric Mean 1.49**B,*C 0.210*D 0.320 0.637 25th to 75th percentile 0.801–2.79 0.028–1.05 0.267–0.763 0.223–3.31 Relative to Group D 235% 33% 50% 100% Core-Glycosylated OATP1B3 Geometric Mean 3.59**B,**C,*D 0.495 0.399 0.710 25th to 75th percentile 2.41–5.11 0.240–2.17 0.319–1.11 0.471–2.08 Relative to Group D 505% 70% 56% 100% Total OATP1B3 Geometric Mean 5.31**B,**C,*D 0.956 0.873 1.49 25th to 75th percentile 3.33–7.86 0.412–3.37 0.720–2.21 0.671–4.95 Relative to Group D 357% 64% 59% 100% OAPT1B1 Geometric Mean 0.0535 0.0445 0.0277 0.139 25th to 75th percentile 0.0045–0.296 0.0107–0.196 0.0155–0.0947 0.0275–0.871 Relative to Group D 38% 32% 20% 100% Statistically significant differences are marked with asterisks (*P ≤ 0.05 and **P < 0.01); superscript letters denote the comparison group.
In this issue
Ontogeny of Organic Anion Transporting Polypeptide in Liver
