Research ArticleArticle
Clearance Prediction of Targeted Covalent Inhibitors by In Vitro-In Vivo Extrapolation of Hepatic and Extrahepatic Clearance Mechanisms
Louis Leung, Xin Yang, Timothy J. Strelevitz, Justin Montgomery, Matthew F. Brown, Michael A. Zientek, Christopher Banfield, Adam M. Gilbert, Atli Thorarensen and Martin E. Dowty
Drug Metabolism and Disposition January 2017, 45 (1) 1-7; DOI: https://doi.org/10.1124/dmd.116.072983
Louis Leung
Pfizer Worldwide Research and Development; Pharmacokinetics, Dynamics and Metabolism, Groton, Connecticut (L.L., X.Y., T.J.S.), Andover, Massachusetts (M.E.D.), and La Jolla, California (M.A.Z.); Medicinal Chemistry, Cambridge, Massachusetts (A.T.), and Groton, Connecticut (J.M., M.F.B., A.M.G.); and Clinical Research, Cambridge, Massachusetts (C.B.)
Xin Yang
Pfizer Worldwide Research and Development; Pharmacokinetics, Dynamics and Metabolism, Groton, Connecticut (L.L., X.Y., T.J.S.), Andover, Massachusetts (M.E.D.), and La Jolla, California (M.A.Z.); Medicinal Chemistry, Cambridge, Massachusetts (A.T.), and Groton, Connecticut (J.M., M.F.B., A.M.G.); and Clinical Research, Cambridge, Massachusetts (C.B.)
Timothy J. Strelevitz
Pfizer Worldwide Research and Development; Pharmacokinetics, Dynamics and Metabolism, Groton, Connecticut (L.L., X.Y., T.J.S.), Andover, Massachusetts (M.E.D.), and La Jolla, California (M.A.Z.); Medicinal Chemistry, Cambridge, Massachusetts (A.T.), and Groton, Connecticut (J.M., M.F.B., A.M.G.); and Clinical Research, Cambridge, Massachusetts (C.B.)
Justin Montgomery
Pfizer Worldwide Research and Development; Pharmacokinetics, Dynamics and Metabolism, Groton, Connecticut (L.L., X.Y., T.J.S.), Andover, Massachusetts (M.E.D.), and La Jolla, California (M.A.Z.); Medicinal Chemistry, Cambridge, Massachusetts (A.T.), and Groton, Connecticut (J.M., M.F.B., A.M.G.); and Clinical Research, Cambridge, Massachusetts (C.B.)
Matthew F. Brown
Pfizer Worldwide Research and Development; Pharmacokinetics, Dynamics and Metabolism, Groton, Connecticut (L.L., X.Y., T.J.S.), Andover, Massachusetts (M.E.D.), and La Jolla, California (M.A.Z.); Medicinal Chemistry, Cambridge, Massachusetts (A.T.), and Groton, Connecticut (J.M., M.F.B., A.M.G.); and Clinical Research, Cambridge, Massachusetts (C.B.)
Michael A. Zientek
Pfizer Worldwide Research and Development; Pharmacokinetics, Dynamics and Metabolism, Groton, Connecticut (L.L., X.Y., T.J.S.), Andover, Massachusetts (M.E.D.), and La Jolla, California (M.A.Z.); Medicinal Chemistry, Cambridge, Massachusetts (A.T.), and Groton, Connecticut (J.M., M.F.B., A.M.G.); and Clinical Research, Cambridge, Massachusetts (C.B.)
Christopher Banfield
Pfizer Worldwide Research and Development; Pharmacokinetics, Dynamics and Metabolism, Groton, Connecticut (L.L., X.Y., T.J.S.), Andover, Massachusetts (M.E.D.), and La Jolla, California (M.A.Z.); Medicinal Chemistry, Cambridge, Massachusetts (A.T.), and Groton, Connecticut (J.M., M.F.B., A.M.G.); and Clinical Research, Cambridge, Massachusetts (C.B.)
Adam M. Gilbert
Pfizer Worldwide Research and Development; Pharmacokinetics, Dynamics and Metabolism, Groton, Connecticut (L.L., X.Y., T.J.S.), Andover, Massachusetts (M.E.D.), and La Jolla, California (M.A.Z.); Medicinal Chemistry, Cambridge, Massachusetts (A.T.), and Groton, Connecticut (J.M., M.F.B., A.M.G.); and Clinical Research, Cambridge, Massachusetts (C.B.)
Atli Thorarensen
Pfizer Worldwide Research and Development; Pharmacokinetics, Dynamics and Metabolism, Groton, Connecticut (L.L., X.Y., T.J.S.), Andover, Massachusetts (M.E.D.), and La Jolla, California (M.A.Z.); Medicinal Chemistry, Cambridge, Massachusetts (A.T.), and Groton, Connecticut (J.M., M.F.B., A.M.G.); and Clinical Research, Cambridge, Massachusetts (C.B.)
Martin E. Dowty
Pfizer Worldwide Research and Development; Pharmacokinetics, Dynamics and Metabolism, Groton, Connecticut (L.L., X.Y., T.J.S.), Andover, Massachusetts (M.E.D.), and La Jolla, California (M.A.Z.); Medicinal Chemistry, Cambridge, Massachusetts (A.T.), and Groton, Connecticut (J.M., M.F.B., A.M.G.); and Clinical Research, Cambridge, Massachusetts (C.B.)
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In this issue
Research ArticleArticle
In Vitro-In Vivo Clearance Prediction of Covalent Inhibitors
Louis Leung, Xin Yang, Timothy J. Strelevitz, Justin Montgomery, Matthew F. Brown, Michael A. Zientek, Christopher Banfield, Adam M. Gilbert, Atli Thorarensen and Martin E. Dowty
Drug Metabolism and Disposition January 1, 2017, 45 (1) 1-7; DOI: https://doi.org/10.1124/dmd.116.072983
Research ArticleArticle
In Vitro-In Vivo Clearance Prediction of Covalent Inhibitors
Louis Leung, Xin Yang, Timothy J. Strelevitz, Justin Montgomery, Matthew F. Brown, Michael A. Zientek, Christopher Banfield, Adam M. Gilbert, Atli Thorarensen and Martin E. Dowty
Drug Metabolism and Disposition January 1, 2017, 45 (1) 1-7; DOI: https://doi.org/10.1124/dmd.116.072983
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