Hepatocyte-Specific Deletion of EGFR in Mice Reduces Hepatic Abcg2 Transport Activity Measured by [11C]erlotinib and Positron Emission Tomography

Alexander Traxl; Karin Komposch; Elisabeth Glitzner; Thomas Wanek; Severin Mairinger; Oliver Langer; Maria Sibilia

doi:10.1124/dmd.117.077081

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Hepatocyte-Specific Deletion of EGFR in Mice Reduces Hepatic Abcg2 Transport Activity Measured by [¹¹C]erlotinib and Positron Emission Tomography

Alexander Traxl, Karin Komposch, Elisabeth Glitzner, Thomas Wanek, Severin Mairinger, Oliver Langer and Maria Sibilia

Drug Metabolism and Disposition October 2017, 45 (10) 1093-1100; DOI: https://doi.org/10.1124/dmd.117.077081

Alexander Traxl

Center for Health and Bioresources, Biomedical Systems, AIT Austrian Institute of Technology GmbH, Seibersdorf, Austria (A.T., T.W., S.M., O.L.); Institute of Cancer Research, Department of Medicine I, Comprehensive Cancer Center (K.K., E.G., M.S.); Department of Clinical Pharmacology (O.L.) and Department of Biomedical Imaging and Image-Guided Therapy, Division of Nuclear Medicine (O.L.), Medical University of Vienna, Vienna, Austria

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Karin Komposch

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Elisabeth Glitzner

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Thomas Wanek

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Severin Mairinger

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Oliver Langer

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Maria Sibilia

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Article Information

vol. 45 no. 10 1093-1100

DOI

https://doi.org/10.1124/dmd.117.077081

PubMed

28790147

Published By

American Society for Pharmacology and Experimental Therapeutics

Print ISSN

0090-9556

Online ISSN

1521-009X

History

Received June 20, 2017
Accepted August 4, 2017
Published online September 11, 2017.

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Earlier version (August 8, 2017 - 07:04).
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Author Information

Alexander Traxl¹,
Karin Komposch¹,
Elisabeth Glitzner¹,
Thomas Wanek,
Severin Mairinger,
Oliver Langer², and
Maria Sibilia²

Center for Health and Bioresources, Biomedical Systems, AIT Austrian Institute of Technology GmbH, Seibersdorf, Austria (A.T., T.W., S.M., O.L.); Institute of Cancer Research, Department of Medicine I, Comprehensive Cancer Center (K.K., E.G., M.S.); Department of Clinical Pharmacology (O.L.) and Department of Biomedical Imaging and Image-Guided Therapy, Division of Nuclear Medicine (O.L.), Medical University of Vienna, Vienna, Austria

Address correspondence to:
Oliver Langer, Center for Health and Bioresources, Biomedical Systems, AIT Austrian Institute of Technology GmbH, 2444 Seibersdorf, Austria. E-mail: oliver.langer{at}ait.ac.at; or Maria Sibilia, Institute of Cancer Research, Department of Medicine I, Comprehensive Cancer Center, Medical University of Vienna, Borschkegasse 8a, A-1090 Vienna, Austria. E-mail: maria.sibilia{at}meduniwien.ac.at

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