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Drug Metabolism & Disposition

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Index by author

November 01, 2018; Volume 46,Issue 11
  • A
  • B
  • C
  • D
  • E
  • F
  • G
  • H
  • I
  • J
  • K
  • L
  • M
  • N
  • O
  • P
  • Q
  • R
  • S
  • T
  • U
  • V
  • W
  • X
  • Y
  • Z

A

  1. Abe, Satoshi

    1. You have access
      Characterization of P-Glycoprotein Humanized Mice Generated by Chromosome Engineering Technology: Its Utility for Prediction of Drug Distribution to the Brain in Humans
      Yuki Yamasaki, Kaoru Kobayashi, Fuka Okuya, Naoyo Kajitani, Kanako Kazuki, Satoshi Abe, Shoko Takehara, Shingo Ito, Seiryo Ogata, Tatsuki Uemura, Sumio Ohtsuki, Genki Minegishi, Hidetaka Akita, Kan Chiba, Mitsuo Oshimura and Yasuhiro Kazuki
      Drug Metabolism and Disposition November 2018, 46 (11) 1756-1766; DOI: https://doi.org/10.1124/dmd.118.081216
  2. Akagawa, Takumi

    1. You have access
      Generation of Intestinal Organoids Suitable for Pharmacokinetic Studies from Human Induced Pluripotent Stem Cells
      Daichi Onozato, Misaki Yamashita, Anna Nakanishi, Takumi Akagawa, Yuriko Kida, Isamu Ogawa, Tadahiro Hashita, Takahiro Iwao and Tamihide Matsunaga
      Drug Metabolism and Disposition November 2018, 46 (11) 1572-1580; DOI: https://doi.org/10.1124/dmd.118.080374
  3. Akazawa, Takanori

    1. You have access
      Application of Intestinal Epithelial Cells Differentiated from Human Induced Pluripotent Stem Cells for Studies of Prodrug Hydrolysis and Drug Absorption in the Small Intestine
      Takanori Akazawa, Shinpei Yoshida, Shuichi Ohnishi, Takushi Kanazu, Makoto Kawai and Koji Takahashi
      Drug Metabolism and Disposition November 2018, 46 (11) 1497-1506; DOI: https://doi.org/10.1124/dmd.118.083246
  4. Akita, Hidetaka

    1. You have access
      Characterization of P-Glycoprotein Humanized Mice Generated by Chromosome Engineering Technology: Its Utility for Prediction of Drug Distribution to the Brain in Humans
      Yuki Yamasaki, Kaoru Kobayashi, Fuka Okuya, Naoyo Kajitani, Kanako Kazuki, Satoshi Abe, Shoko Takehara, Shingo Ito, Seiryo Ogata, Tatsuki Uemura, Sumio Ohtsuki, Genki Minegishi, Hidetaka Akita, Kan Chiba, Mitsuo Oshimura and Yasuhiro Kazuki
      Drug Metabolism and Disposition November 2018, 46 (11) 1756-1766; DOI: https://doi.org/10.1124/dmd.118.081216
  5. Alam, Novera

    1. You have access
      Cryopreserved Human Intestinal Mucosal Epithelium: A Novel In Vitro Experimental System for the Evaluation of Enteric Drug Metabolism, Cytochrome P450 Induction, and Enterotoxicity
      Albert P. Li, Novera Alam, Kirsten Amaral, Ming-Chih David Ho, Carol Loretz, Walter Mitchell and Qian Yang
      Drug Metabolism and Disposition November 2018, 46 (11) 1562-1571; DOI: https://doi.org/10.1124/dmd.118.082875
  6. Alqahtani, Faleh

    1. You have access
      Brain Uptake of [13C] and [14C]Sucrose Quantified by Microdialysis and Whole Tissue Analysis in Mice
      Faleh Alqahtani, Ekram Ahmed Chowdhury, Raktima Bhattacharya, Behnam Noorani, Reza Mehvar and Ulrich Bickel
      Drug Metabolism and Disposition November 2018, 46 (11) 1514-1518; DOI: https://doi.org/10.1124/dmd.118.082909
  7. Amaral, Kirsten

    1. You have access
      A Novel In Vitro Experimental System for the Evaluation of Drug Metabolism: Cofactor-Supplemented Permeabilized Cryopreserved Human Hepatocytes (MetMax Cryopreserved Human Hepatocytes)
      Albert P. Li, Ming-Chih David Ho, Kirsten Amaral and Carol Loretz
      Drug Metabolism and Disposition November 2018, 46 (11) 1608-1616; DOI: https://doi.org/10.1124/dmd.117.079657
    2. You have access
      Cryopreserved Human Intestinal Mucosal Epithelium: A Novel In Vitro Experimental System for the Evaluation of Enteric Drug Metabolism, Cytochrome P450 Induction, and Enterotoxicity
      Albert P. Li, Novera Alam, Kirsten Amaral, Ming-Chih David Ho, Carol Loretz, Walter Mitchell and Qian Yang
      Drug Metabolism and Disposition November 2018, 46 (11) 1562-1571; DOI: https://doi.org/10.1124/dmd.118.082875
  8. Anderson, Shelby

    1. You have access
      Assessment of the Biotransformation of Low-Turnover Drugs in the HµREL Human Hepatocyte Coculture Model
      Richard D. Burton, Todd Hieronymus, Taysir Chamem, David Heim, Shelby Anderson, Xiaochun Zhu and J. Matthew Hutzler
      Drug Metabolism and Disposition November 2018, 46 (11) 1617-1625; DOI: https://doi.org/10.1124/dmd.118.082867
  9. Annaert, Pieter

    1. You have access
      Relationship between In Vivo CYP3A4 Activity, CYP3A5 Genotype, and Systemic Tacrolimus Metabolite/Parent Drug Ratio in Renal Transplant Recipients and Healthy Volunteers
      Thomas Vanhove, Hylke de Jonge, Henriëtte de Loor, Marlies Oorts, Jan de Hoon, Anton Pohanka, Pieter Annaert and Dirk R. J. Kuypers
      Drug Metabolism and Disposition November 2018, 46 (11) 1507-1513; DOI: https://doi.org/10.1124/dmd.118.081935
  10. Argikar, Upendra A.

    1. You have access
      Models and Approaches Describing the Metabolism, Transport, and Toxicity of Drugs Administered by the Ocular Route
      Jennifer L. Dumouchel, Nagendra Chemuturi, Mark N. Milton, Gian Camenisch, James Chastain, Markus Walles, Vito Sasseville, Mithat Gunduz, Ganesh R. Iyer and Upendra A. Argikar
      Drug Metabolism and Disposition November 2018, 46 (11) 1670-1683; DOI: https://doi.org/10.1124/dmd.118.082974
  11. Artursson, P.

    1. Open Access
      CRISPR-Cas9: A New Addition to the Drug Metabolism and Disposition Tool Box
      M. Karlgren, I. Simoff, M. Keiser, S. Oswald and P. Artursson
      Drug Metabolism and Disposition November 2018, 46 (11) 1776-1786; DOI: https://doi.org/10.1124/dmd.118.082842

B

  1. Bajaj, Piyush

    1. You have access
      Human Pluripotent Stem Cell–Derived Kidney Model for Nephrotoxicity Studies
      Piyush Bajaj, A. David Rodrigues, Claire M. Steppan, Sandra J. Engle, Sumathy Mathialagan and Thomas Schroeter
      Drug Metabolism and Disposition November 2018, 46 (11) 1703-1711; DOI: https://doi.org/10.1124/dmd.118.082727
    2. You have access
      Emerging Kidney Models to Investigate Metabolism, Transport, and Toxicity of Drugs and Xenobiotics
      Piyush Bajaj, Swapan K. Chowdhury, Robert Yucha, Edward J. Kelly and Guangqing Xiao
      Drug Metabolism and Disposition November 2018, 46 (11) 1692-1702; DOI: https://doi.org/10.1124/dmd.118.082958
  2. Bale, Shyam Sundhar

    1. You have access
      Microfluidic Cell Culture Platforms to Capture Hepatic Physiology and Complex Cellular Interactions
      Shyam Sundhar Bale and Jeffrey T. Borenstein
      Drug Metabolism and Disposition November 2018, 46 (11) 1638-1646; DOI: https://doi.org/10.1124/dmd.118.083055
  3. Barzi, Mercedes

    1. You have access
      P450-Humanized and Human Liver Chimeric Mouse Models for Studying Xenobiotic Metabolism and Toxicity
      Karl-Dimiter Bissig, Weiguo Han, Mercedes Barzi, Nataliia Kovalchuk, Liang Ding, Xiaoyu Fan, Francis P. Pankowicz, Qing-Yu Zhang and Xinxin Ding
      Drug Metabolism and Disposition November 2018, 46 (11) 1734-1744; DOI: https://doi.org/10.1124/dmd.118.083303
  4. Baumgart, Jan

    1. You have access
      Health-Relevant Phenotypes in the Offspring of Mice Given CAR Activators Prior to Pregnancy
      Karin Dietrich, Jan Baumgart, Leonid Eshkind, Lea Reuter, Ute Gödtel-Armbrust, Elke Butt, Michael Musheev, Federico Marini, Piyush More, Tanja Grosser, Christof Niehrs, Leszek Wojnowski and Marianne Mathäs
      Drug Metabolism and Disposition November 2018, 46 (11) 1827-1835; DOI: https://doi.org/10.1124/dmd.118.082925
  5. Bederman, Ilya R.

    1. Retinal Cholesterol Content Is Reduced in Simvastatin-Treated Mice Due to Inhibited Local Biosynthesis Albeit Increased Uptake of Serum Cholesterol
      You have access
      Retinal Cholesterol Content Is Reduced in Simvastatin-Treated Mice Due to Inhibited Local Biosynthesis Albeit Increased Uptake of Serum Cholesterol
      Natalia Mast, Ilya R. Bederman and Irina A. Pikuleva
      Drug Metabolism and Disposition November 2018, 46 (11) 1528-1537; DOI: https://doi.org/10.1124/dmd.118.083345
  6. Berellini, Giuliano

    1. You have access
      Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds
      Franco Lombardo, Giuliano Berellini and R. Scott Obach
      Drug Metabolism and Disposition November 2018, 46 (11) 1466-1477; DOI: https://doi.org/10.1124/dmd.118.082966
  7. Bhattacharya, Raktima

    1. You have access
      Brain Uptake of [13C] and [14C]Sucrose Quantified by Microdialysis and Whole Tissue Analysis in Mice
      Faleh Alqahtani, Ekram Ahmed Chowdhury, Raktima Bhattacharya, Behnam Noorani, Reza Mehvar and Ulrich Bickel
      Drug Metabolism and Disposition November 2018, 46 (11) 1514-1518; DOI: https://doi.org/10.1124/dmd.118.082909
  8. Bickel, Ulrich

    1. You have access
      Brain Uptake of [13C] and [14C]Sucrose Quantified by Microdialysis and Whole Tissue Analysis in Mice
      Faleh Alqahtani, Ekram Ahmed Chowdhury, Raktima Bhattacharya, Behnam Noorani, Reza Mehvar and Ulrich Bickel
      Drug Metabolism and Disposition November 2018, 46 (11) 1514-1518; DOI: https://doi.org/10.1124/dmd.118.082909
  9. Bisanz, Jordan E.

    1. You have access
      How to Determine the Role of the Microbiome in Drug Disposition
      Jordan E. Bisanz, Peter Spanogiannopoulos, Lindsey M. Pieper, Annamarie E. Bustion and Peter J. Turnbaugh
      Drug Metabolism and Disposition November 2018, 46 (11) 1588-1595; DOI: https://doi.org/10.1124/dmd.118.083402
  10. Bissig, Karl-Dimiter

    1. You have access
      P450-Humanized and Human Liver Chimeric Mouse Models for Studying Xenobiotic Metabolism and Toxicity
      Karl-Dimiter Bissig, Weiguo Han, Mercedes Barzi, Nataliia Kovalchuk, Liang Ding, Xiaoyu Fan, Francis P. Pankowicz, Qing-Yu Zhang and Xinxin Ding
      Drug Metabolism and Disposition November 2018, 46 (11) 1734-1744; DOI: https://doi.org/10.1124/dmd.118.083303
  11. Borenstein, Jeffrey T.

    1. You have access
      Microfluidic Cell Culture Platforms to Capture Hepatic Physiology and Complex Cellular Interactions
      Shyam Sundhar Bale and Jeffrey T. Borenstein
      Drug Metabolism and Disposition November 2018, 46 (11) 1638-1646; DOI: https://doi.org/10.1124/dmd.118.083055
  12. Braeuning, Albert

    1. You have access
      Mouse Hepatomas with Ha-ras and B-raf Mutations Differ in Mitogen-Activated Protein Kinase Signaling and Response to Constitutive Androstane Receptor Activation
      Albert Braeuning, Ferdinand Kollotzek, Eva Zeller, Thomas Knorpp, Markus F. Templin and Michael Schwarz
      Drug Metabolism and Disposition November 2018, 46 (11) 1462-1465; DOI: https://doi.org/10.1124/dmd.118.083014
  13. Burton, Richard D.

    1. You have access
      Assessment of the Biotransformation of Low-Turnover Drugs in the HµREL Human Hepatocyte Coculture Model
      Richard D. Burton, Todd Hieronymus, Taysir Chamem, David Heim, Shelby Anderson, Xiaochun Zhu and J. Matthew Hutzler
      Drug Metabolism and Disposition November 2018, 46 (11) 1617-1625; DOI: https://doi.org/10.1124/dmd.118.082867
  14. Bustion, Annamarie E.

    1. You have access
      How to Determine the Role of the Microbiome in Drug Disposition
      Jordan E. Bisanz, Peter Spanogiannopoulos, Lindsey M. Pieper, Annamarie E. Bustion and Peter J. Turnbaugh
      Drug Metabolism and Disposition November 2018, 46 (11) 1588-1595; DOI: https://doi.org/10.1124/dmd.118.083402
  15. Butt, Elke

    1. You have access
      Health-Relevant Phenotypes in the Offspring of Mice Given CAR Activators Prior to Pregnancy
      Karin Dietrich, Jan Baumgart, Leonid Eshkind, Lea Reuter, Ute Gödtel-Armbrust, Elke Butt, Michael Musheev, Federico Marini, Piyush More, Tanja Grosser, Christof Niehrs, Leszek Wojnowski and Marianne Mathäs
      Drug Metabolism and Disposition November 2018, 46 (11) 1827-1835; DOI: https://doi.org/10.1124/dmd.118.082925

C

  1. Caetano-Pinto, Pedro

    1. You have access
      Perspective on the Application of Microphysiological Systems to Drug Transporter Studies
      Pedro Caetano-Pinto and Simone H. Stahl
      Drug Metabolism and Disposition November 2018, 46 (11) 1647-1657; DOI: https://doi.org/10.1124/dmd.118.082750
  2. Camenisch, Gian

    1. You have access
      Models and Approaches Describing the Metabolism, Transport, and Toxicity of Drugs Administered by the Ocular Route
      Jennifer L. Dumouchel, Nagendra Chemuturi, Mark N. Milton, Gian Camenisch, James Chastain, Markus Walles, Vito Sasseville, Mithat Gunduz, Ganesh R. Iyer and Upendra A. Argikar
      Drug Metabolism and Disposition November 2018, 46 (11) 1670-1683; DOI: https://doi.org/10.1124/dmd.118.082974
  3. Ceckova, Martina

    1. You have access
      Equilibrative Nucleoside Transporter 1 (ENT1, SLC29A1) Facilitates Transfer of the Antiretroviral Drug Abacavir across the Placenta
      Lukas Cerveny, Zuzana Ptackova, Martina Ceckova, Rona Karahoda, Sara Karbanova, Lucie Jiraskova, Susan L. Greenwood, Jocelyn D. Glazier and Frantisek Staud
      Drug Metabolism and Disposition November 2018, 46 (11) 1817-1826; DOI: https://doi.org/10.1124/dmd.118.083329
  4. Cerveny, Lukas

    1. You have access
      Equilibrative Nucleoside Transporter 1 (ENT1, SLC29A1) Facilitates Transfer of the Antiretroviral Drug Abacavir across the Placenta
      Lukas Cerveny, Zuzana Ptackova, Martina Ceckova, Rona Karahoda, Sara Karbanova, Lucie Jiraskova, Susan L. Greenwood, Jocelyn D. Glazier and Frantisek Staud
      Drug Metabolism and Disposition November 2018, 46 (11) 1817-1826; DOI: https://doi.org/10.1124/dmd.118.083329
  5. Chamem, Taysir

    1. You have access
      Assessment of the Biotransformation of Low-Turnover Drugs in the HµREL Human Hepatocyte Coculture Model
      Richard D. Burton, Todd Hieronymus, Taysir Chamem, David Heim, Shelby Anderson, Xiaochun Zhu and J. Matthew Hutzler
      Drug Metabolism and Disposition November 2018, 46 (11) 1617-1625; DOI: https://doi.org/10.1124/dmd.118.082867
  6. Chastain, James

    1. You have access
      Models and Approaches Describing the Metabolism, Transport, and Toxicity of Drugs Administered by the Ocular Route
      Jennifer L. Dumouchel, Nagendra Chemuturi, Mark N. Milton, Gian Camenisch, James Chastain, Markus Walles, Vito Sasseville, Mithat Gunduz, Ganesh R. Iyer and Upendra A. Argikar
      Drug Metabolism and Disposition November 2018, 46 (11) 1670-1683; DOI: https://doi.org/10.1124/dmd.118.082974
  7. Chemuturi, Nagendra

    1. You have access
      Models and Approaches Describing the Metabolism, Transport, and Toxicity of Drugs Administered by the Ocular Route
      Jennifer L. Dumouchel, Nagendra Chemuturi, Mark N. Milton, Gian Camenisch, James Chastain, Markus Walles, Vito Sasseville, Mithat Gunduz, Ganesh R. Iyer and Upendra A. Argikar
      Drug Metabolism and Disposition November 2018, 46 (11) 1670-1683; DOI: https://doi.org/10.1124/dmd.118.082974
  8. Chen, Shujuan

    1. You have access
      Humanized UGT1 Mice, Regulation of UGT1A1, and the Role of the Intestinal Tract in Neonatal Hyperbilirubinemia and Breast Milk-Induced Jaundice
      Shujuan Chen and Robert H. Tukey
      Drug Metabolism and Disposition November 2018, 46 (11) 1745-1755; DOI: https://doi.org/10.1124/dmd.118.083212
  9. Cherrington, Nathan J.

    1. You have access
      Gene-by-Environment Interaction of Bcrp−/− and Methionine- and Choline-Deficient Diet–Induced Nonalcoholic Steatohepatitis Alters SN-38 Disposition
      Erica L. Toth, Hui Li, Anika L. Dzierlenga, John D. Clarke, Anna Vildhede, Michael Goedken and Nathan J. Cherrington
      Drug Metabolism and Disposition November 2018, 46 (11) 1478-1486; DOI: https://doi.org/10.1124/dmd.118.082081
  10. Chiba, Kan

    1. You have access
      Characterization of P-Glycoprotein Humanized Mice Generated by Chromosome Engineering Technology: Its Utility for Prediction of Drug Distribution to the Brain in Humans
      Yuki Yamasaki, Kaoru Kobayashi, Fuka Okuya, Naoyo Kajitani, Kanako Kazuki, Satoshi Abe, Shoko Takehara, Shingo Ito, Seiryo Ogata, Tatsuki Uemura, Sumio Ohtsuki, Genki Minegishi, Hidetaka Akita, Kan Chiba, Mitsuo Oshimura and Yasuhiro Kazuki
      Drug Metabolism and Disposition November 2018, 46 (11) 1756-1766; DOI: https://doi.org/10.1124/dmd.118.081216
  11. Chowdhury, Ekram Ahmed

    1. You have access
      Brain Uptake of [13C] and [14C]Sucrose Quantified by Microdialysis and Whole Tissue Analysis in Mice
      Faleh Alqahtani, Ekram Ahmed Chowdhury, Raktima Bhattacharya, Behnam Noorani, Reza Mehvar and Ulrich Bickel
      Drug Metabolism and Disposition November 2018, 46 (11) 1514-1518; DOI: https://doi.org/10.1124/dmd.118.082909
  12. Chowdhury, Swapan K.

    1. You have access
      Emerging Kidney Models to Investigate Metabolism, Transport, and Toxicity of Drugs and Xenobiotics
      Piyush Bajaj, Swapan K. Chowdhury, Robert Yucha, Edward J. Kelly and Guangqing Xiao
      Drug Metabolism and Disposition November 2018, 46 (11) 1692-1702; DOI: https://doi.org/10.1124/dmd.118.082958
  13. Clarke, John D.

    1. You have access
      Gene-by-Environment Interaction of Bcrp−/− and Methionine- and Choline-Deficient Diet–Induced Nonalcoholic Steatohepatitis Alters SN-38 Disposition
      Erica L. Toth, Hui Li, Anika L. Dzierlenga, John D. Clarke, Anna Vildhede, Michael Goedken and Nathan J. Cherrington
      Drug Metabolism and Disposition November 2018, 46 (11) 1478-1486; DOI: https://doi.org/10.1124/dmd.118.082081

D

  1. de Hoon, Jan

    1. You have access
      Relationship between In Vivo CYP3A4 Activity, CYP3A5 Genotype, and Systemic Tacrolimus Metabolite/Parent Drug Ratio in Renal Transplant Recipients and Healthy Volunteers
      Thomas Vanhove, Hylke de Jonge, Henriëtte de Loor, Marlies Oorts, Jan de Hoon, Anton Pohanka, Pieter Annaert and Dirk R. J. Kuypers
      Drug Metabolism and Disposition November 2018, 46 (11) 1507-1513; DOI: https://doi.org/10.1124/dmd.118.081935
  2. de Jonge, Hylke

    1. You have access
      Relationship between In Vivo CYP3A4 Activity, CYP3A5 Genotype, and Systemic Tacrolimus Metabolite/Parent Drug Ratio in Renal Transplant Recipients and Healthy Volunteers
      Thomas Vanhove, Hylke de Jonge, Henriëtte de Loor, Marlies Oorts, Jan de Hoon, Anton Pohanka, Pieter Annaert and Dirk R. J. Kuypers
      Drug Metabolism and Disposition November 2018, 46 (11) 1507-1513; DOI: https://doi.org/10.1124/dmd.118.081935
  3. de Loor, Henriëtte

    1. You have access
      Relationship between In Vivo CYP3A4 Activity, CYP3A5 Genotype, and Systemic Tacrolimus Metabolite/Parent Drug Ratio in Renal Transplant Recipients and Healthy Volunteers
      Thomas Vanhove, Hylke de Jonge, Henriëtte de Loor, Marlies Oorts, Jan de Hoon, Anton Pohanka, Pieter Annaert and Dirk R. J. Kuypers
      Drug Metabolism and Disposition November 2018, 46 (11) 1507-1513; DOI: https://doi.org/10.1124/dmd.118.081935
  4. Deng, Jiangming

    1. You have access
      Circadian Regulation of Hepatic Cytochrome P450 2a5 by Peroxisome Proliferator-Activated Receptor γ
      Jiangming Deng, Lianxia Guo and Baojian Wu
      Drug Metabolism and Disposition November 2018, 46 (11) 1538-1545; DOI: https://doi.org/10.1124/dmd.118.083071
  5. Dietrich, Karin

    1. You have access
      Health-Relevant Phenotypes in the Offspring of Mice Given CAR Activators Prior to Pregnancy
      Karin Dietrich, Jan Baumgart, Leonid Eshkind, Lea Reuter, Ute Gödtel-Armbrust, Elke Butt, Michael Musheev, Federico Marini, Piyush More, Tanja Grosser, Christof Niehrs, Leszek Wojnowski and Marianne Mathäs
      Drug Metabolism and Disposition November 2018, 46 (11) 1827-1835; DOI: https://doi.org/10.1124/dmd.118.082925
  6. Ding, Liang

    1. You have access
      P450-Humanized and Human Liver Chimeric Mouse Models for Studying Xenobiotic Metabolism and Toxicity
      Karl-Dimiter Bissig, Weiguo Han, Mercedes Barzi, Nataliia Kovalchuk, Liang Ding, Xiaoyu Fan, Francis P. Pankowicz, Qing-Yu Zhang and Xinxin Ding
      Drug Metabolism and Disposition November 2018, 46 (11) 1734-1744; DOI: https://doi.org/10.1124/dmd.118.083303
  7. Ding, Xinxin

    1. You have access
      P450-Humanized and Human Liver Chimeric Mouse Models for Studying Xenobiotic Metabolism and Toxicity
      Karl-Dimiter Bissig, Weiguo Han, Mercedes Barzi, Nataliia Kovalchuk, Liang Ding, Xiaoyu Fan, Francis P. Pankowicz, Qing-Yu Zhang and Xinxin Ding
      Drug Metabolism and Disposition November 2018, 46 (11) 1734-1744; DOI: https://doi.org/10.1124/dmd.118.083303
  8. Doyonnas, Regis

    1. You have access
      Physiologically Relevant, Humanized Intestinal Systems to Study Metabolism and Transport of Small Molecule Therapeutics
      Aarti Sawant-Basak, A. David Rodrigues, Matthew Lech, Regis Doyonnas, Marion Kasaian, Bhagwat Prasad and Nikolaos Tsamandouras
      Drug Metabolism and Disposition November 2018, 46 (11) 1581-1587; DOI: https://doi.org/10.1124/dmd.118.082784
  9. Dumouchel, Jennifer L.

    1. You have access
      Models and Approaches Describing the Metabolism, Transport, and Toxicity of Drugs Administered by the Ocular Route
      Jennifer L. Dumouchel, Nagendra Chemuturi, Mark N. Milton, Gian Camenisch, James Chastain, Markus Walles, Vito Sasseville, Mithat Gunduz, Ganesh R. Iyer and Upendra A. Argikar
      Drug Metabolism and Disposition November 2018, 46 (11) 1670-1683; DOI: https://doi.org/10.1124/dmd.118.082974
  10. Dzierlenga, Anika L.

    1. You have access
      Gene-by-Environment Interaction of Bcrp−/− and Methionine- and Choline-Deficient Diet–Induced Nonalcoholic Steatohepatitis Alters SN-38 Disposition
      Erica L. Toth, Hui Li, Anika L. Dzierlenga, John D. Clarke, Anna Vildhede, Michael Goedken and Nathan J. Cherrington
      Drug Metabolism and Disposition November 2018, 46 (11) 1478-1486; DOI: https://doi.org/10.1124/dmd.118.082081

E

  1. Engelen, Anna

    1. Open Access
      Biotransformation of Finerenone, a Novel Nonsteroidal Mineralocorticoid Receptor Antagonist, in Dogs, Rats, and Humans, In Vivo and In Vitro
      Michael Gerisch, Roland Heinig, Anna Engelen, Dieter Lang, Peter Kolkhof, Martin Radtke, Johannes Platzek, Kai Lovis, Gabriele Rohde and Thomas Schwarz
      Drug Metabolism and Disposition November 2018, 46 (11) 1546-1555; DOI: https://doi.org/10.1124/dmd.118.083337
  2. Engle, Sandra J.

    1. You have access
      Human Pluripotent Stem Cell–Derived Kidney Model for Nephrotoxicity Studies
      Piyush Bajaj, A. David Rodrigues, Claire M. Steppan, Sandra J. Engle, Sumathy Mathialagan and Thomas Schroeter
      Drug Metabolism and Disposition November 2018, 46 (11) 1703-1711; DOI: https://doi.org/10.1124/dmd.118.082727
  3. Eshkind, Leonid

    1. You have access
      Health-Relevant Phenotypes in the Offspring of Mice Given CAR Activators Prior to Pregnancy
      Karin Dietrich, Jan Baumgart, Leonid Eshkind, Lea Reuter, Ute Gödtel-Armbrust, Elke Butt, Michael Musheev, Federico Marini, Piyush More, Tanja Grosser, Christof Niehrs, Leszek Wojnowski and Marianne Mathäs
      Drug Metabolism and Disposition November 2018, 46 (11) 1827-1835; DOI: https://doi.org/10.1124/dmd.118.082925

F

  1. Fan, Xiaoyu

    1. You have access
      P450-Humanized and Human Liver Chimeric Mouse Models for Studying Xenobiotic Metabolism and Toxicity
      Karl-Dimiter Bissig, Weiguo Han, Mercedes Barzi, Nataliia Kovalchuk, Liang Ding, Xiaoyu Fan, Francis P. Pankowicz, Qing-Yu Zhang and Xinxin Ding
      Drug Metabolism and Disposition November 2018, 46 (11) 1734-1744; DOI: https://doi.org/10.1124/dmd.118.083303

G

  1. Ganguly, Samit

    1. Pheophorbide A: Fluorescent Bcrp Substrate to Measure Oral Drug-Drug Interactions in Real-Time In Vivo
      You have access
      Pheophorbide A: Fluorescent Bcrp Substrate to Measure Oral Drug-Drug Interactions in Real-Time In Vivo
      Kazuto Yasuda, Samit Ganguly and Erin G. Schuetz
      Drug Metabolism and Disposition November 2018, 46 (11) 1725-1733; DOI: https://doi.org/10.1124/dmd.118.083584
  2. Gerisch, Michael

    1. Open Access
      Biotransformation of Finerenone, a Novel Nonsteroidal Mineralocorticoid Receptor Antagonist, in Dogs, Rats, and Humans, In Vivo and In Vitro
      Michael Gerisch, Roland Heinig, Anna Engelen, Dieter Lang, Peter Kolkhof, Martin Radtke, Johannes Platzek, Kai Lovis, Gabriele Rohde and Thomas Schwarz
      Drug Metabolism and Disposition November 2018, 46 (11) 1546-1555; DOI: https://doi.org/10.1124/dmd.118.083337
  3. Glazier, Jocelyn D.

    1. You have access
      Equilibrative Nucleoside Transporter 1 (ENT1, SLC29A1) Facilitates Transfer of the Antiretroviral Drug Abacavir across the Placenta
      Lukas Cerveny, Zuzana Ptackova, Martina Ceckova, Rona Karahoda, Sara Karbanova, Lucie Jiraskova, Susan L. Greenwood, Jocelyn D. Glazier and Frantisek Staud
      Drug Metabolism and Disposition November 2018, 46 (11) 1817-1826; DOI: https://doi.org/10.1124/dmd.118.083329
  4. Gödtel-Armbrust, Ute

    1. You have access
      Health-Relevant Phenotypes in the Offspring of Mice Given CAR Activators Prior to Pregnancy
      Karin Dietrich, Jan Baumgart, Leonid Eshkind, Lea Reuter, Ute Gödtel-Armbrust, Elke Butt, Michael Musheev, Federico Marini, Piyush More, Tanja Grosser, Christof Niehrs, Leszek Wojnowski and Marianne Mathäs
      Drug Metabolism and Disposition November 2018, 46 (11) 1827-1835; DOI: https://doi.org/10.1124/dmd.118.082925
  5. Goedken, Michael

    1. You have access
      Gene-by-Environment Interaction of Bcrp−/− and Methionine- and Choline-Deficient Diet–Induced Nonalcoholic Steatohepatitis Alters SN-38 Disposition
      Erica L. Toth, Hui Li, Anika L. Dzierlenga, John D. Clarke, Anna Vildhede, Michael Goedken and Nathan J. Cherrington
      Drug Metabolism and Disposition November 2018, 46 (11) 1478-1486; DOI: https://doi.org/10.1124/dmd.118.082081
  6. Greenwood, Susan L.

    1. You have access
      Equilibrative Nucleoside Transporter 1 (ENT1, SLC29A1) Facilitates Transfer of the Antiretroviral Drug Abacavir across the Placenta
      Lukas Cerveny, Zuzana Ptackova, Martina Ceckova, Rona Karahoda, Sara Karbanova, Lucie Jiraskova, Susan L. Greenwood, Jocelyn D. Glazier and Frantisek Staud
      Drug Metabolism and Disposition November 2018, 46 (11) 1817-1826; DOI: https://doi.org/10.1124/dmd.118.083329
  7. Grosser, Tanja

    1. You have access
      Health-Relevant Phenotypes in the Offspring of Mice Given CAR Activators Prior to Pregnancy
      Karin Dietrich, Jan Baumgart, Leonid Eshkind, Lea Reuter, Ute Gödtel-Armbrust, Elke Butt, Michael Musheev, Federico Marini, Piyush More, Tanja Grosser, Christof Niehrs, Leszek Wojnowski and Marianne Mathäs
      Drug Metabolism and Disposition November 2018, 46 (11) 1827-1835; DOI: https://doi.org/10.1124/dmd.118.082925
  8. Gunduz, Mithat

    1. You have access
      Models and Approaches Describing the Metabolism, Transport, and Toxicity of Drugs Administered by the Ocular Route
      Jennifer L. Dumouchel, Nagendra Chemuturi, Mark N. Milton, Gian Camenisch, James Chastain, Markus Walles, Vito Sasseville, Mithat Gunduz, Ganesh R. Iyer and Upendra A. Argikar
      Drug Metabolism and Disposition November 2018, 46 (11) 1670-1683; DOI: https://doi.org/10.1124/dmd.118.082974
  9. Guo, Lianxia

    1. You have access
      Circadian Regulation of Hepatic Cytochrome P450 2a5 by Peroxisome Proliferator-Activated Receptor γ
      Jiangming Deng, Lianxia Guo and Baojian Wu
      Drug Metabolism and Disposition November 2018, 46 (11) 1538-1545; DOI: https://doi.org/10.1124/dmd.118.083071

H

  1. Han, Weiguo

    1. You have access
      P450-Humanized and Human Liver Chimeric Mouse Models for Studying Xenobiotic Metabolism and Toxicity
      Karl-Dimiter Bissig, Weiguo Han, Mercedes Barzi, Nataliia Kovalchuk, Liang Ding, Xiaoyu Fan, Francis P. Pankowicz, Qing-Yu Zhang and Xinxin Ding
      Drug Metabolism and Disposition November 2018, 46 (11) 1734-1744; DOI: https://doi.org/10.1124/dmd.118.083303
  2. Han, Yi Rang

    1. You have access
      Finding Tmax and Cmax in Multicompartmental Models
      Yi Rang Han, Ping I. Lee and K. Sandy Pang
      Drug Metabolism and Disposition November 2018, 46 (11) 1796-1804; DOI: https://doi.org/10.1124/dmd.118.082636
  3. Hashita, Tadahiro

    1. You have access
      Effect of Celecoxib on Differentiation of Human Induced Pluripotent Stem Cells into Hepatocytes Involves STAT5 Activation
      Hiroki Okumura, Anna Nakanishi, Tadahiro Hashita, Takahiro Iwao and Tamihide Matsunaga
      Drug Metabolism and Disposition November 2018, 46 (11) 1519-1527; DOI: https://doi.org/10.1124/dmd.118.082982
    2. You have access
      Generation of Intestinal Organoids Suitable for Pharmacokinetic Studies from Human Induced Pluripotent Stem Cells
      Daichi Onozato, Misaki Yamashita, Anna Nakanishi, Takumi Akagawa, Yuriko Kida, Isamu Ogawa, Tadahiro Hashita, Takahiro Iwao and Tamihide Matsunaga
      Drug Metabolism and Disposition November 2018, 46 (11) 1572-1580; DOI: https://doi.org/10.1124/dmd.118.080374
  4. Heerikhuisen, M.

    1. You have access
      An Ex Vivo Fermentation Screening Platform to Study Drug Metabolism by Human Gut Microbiota
      E. van de Steeg, F. H. J. Schuren, R. Scott Obach, C. van Woudenbergh, Gregory S. Walker, M. Heerikhuisen, I. H. G. Nooijen and W. H. J. Vaes
      Drug Metabolism and Disposition November 2018, 46 (11) 1596-1607; DOI: https://doi.org/10.1124/dmd.118.081026
  5. Heim, David

    1. You have access
      Assessment of the Biotransformation of Low-Turnover Drugs in the HµREL Human Hepatocyte Coculture Model
      Richard D. Burton, Todd Hieronymus, Taysir Chamem, David Heim, Shelby Anderson, Xiaochun Zhu and J. Matthew Hutzler
      Drug Metabolism and Disposition November 2018, 46 (11) 1617-1625; DOI: https://doi.org/10.1124/dmd.118.082867
  6. Heinig, Roland

    1. Open Access
      Biotransformation of Finerenone, a Novel Nonsteroidal Mineralocorticoid Receptor Antagonist, in Dogs, Rats, and Humans, In Vivo and In Vitro
      Michael Gerisch, Roland Heinig, Anna Engelen, Dieter Lang, Peter Kolkhof, Martin Radtke, Johannes Platzek, Kai Lovis, Gabriele Rohde and Thomas Schwarz
      Drug Metabolism and Disposition November 2018, 46 (11) 1546-1555; DOI: https://doi.org/10.1124/dmd.118.083337
  7. Hieronymus, Todd

    1. You have access
      Assessment of the Biotransformation of Low-Turnover Drugs in the HµREL Human Hepatocyte Coculture Model
      Richard D. Burton, Todd Hieronymus, Taysir Chamem, David Heim, Shelby Anderson, Xiaochun Zhu and J. Matthew Hutzler
      Drug Metabolism and Disposition November 2018, 46 (11) 1617-1625; DOI: https://doi.org/10.1124/dmd.118.082867
  8. Ho, Ming-Chih David

    1. You have access
      A Novel In Vitro Experimental System for the Evaluation of Drug Metabolism: Cofactor-Supplemented Permeabilized Cryopreserved Human Hepatocytes (MetMax Cryopreserved Human Hepatocytes)
      Albert P. Li, Ming-Chih David Ho, Kirsten Amaral and Carol Loretz
      Drug Metabolism and Disposition November 2018, 46 (11) 1608-1616; DOI: https://doi.org/10.1124/dmd.117.079657
    2. You have access
      Cryopreserved Human Intestinal Mucosal Epithelium: A Novel In Vitro Experimental System for the Evaluation of Enteric Drug Metabolism, Cytochrome P450 Induction, and Enterotoxicity
      Albert P. Li, Novera Alam, Kirsten Amaral, Ming-Chih David Ho, Carol Loretz, Walter Mitchell and Qian Yang
      Drug Metabolism and Disposition November 2018, 46 (11) 1562-1571; DOI: https://doi.org/10.1124/dmd.118.082875
  9. Hutzler, J. Matthew

    1. You have access
      Assessment of the Biotransformation of Low-Turnover Drugs in the HµREL Human Hepatocyte Coculture Model
      Richard D. Burton, Todd Hieronymus, Taysir Chamem, David Heim, Shelby Anderson, Xiaochun Zhu and J. Matthew Hutzler
      Drug Metabolism and Disposition November 2018, 46 (11) 1617-1625; DOI: https://doi.org/10.1124/dmd.118.082867

I

  1. Ito, Shingo

    1. You have access
      Characterization of P-Glycoprotein Humanized Mice Generated by Chromosome Engineering Technology: Its Utility for Prediction of Drug Distribution to the Brain in Humans
      Yuki Yamasaki, Kaoru Kobayashi, Fuka Okuya, Naoyo Kajitani, Kanako Kazuki, Satoshi Abe, Shoko Takehara, Shingo Ito, Seiryo Ogata, Tatsuki Uemura, Sumio Ohtsuki, Genki Minegishi, Hidetaka Akita, Kan Chiba, Mitsuo Oshimura and Yasuhiro Kazuki
      Drug Metabolism and Disposition November 2018, 46 (11) 1756-1766; DOI: https://doi.org/10.1124/dmd.118.081216
  2. Iwao, Takahiro

    1. You have access
      Effect of Celecoxib on Differentiation of Human Induced Pluripotent Stem Cells into Hepatocytes Involves STAT5 Activation
      Hiroki Okumura, Anna Nakanishi, Tadahiro Hashita, Takahiro Iwao and Tamihide Matsunaga
      Drug Metabolism and Disposition November 2018, 46 (11) 1519-1527; DOI: https://doi.org/10.1124/dmd.118.082982
    2. You have access
      Generation of Intestinal Organoids Suitable for Pharmacokinetic Studies from Human Induced Pluripotent Stem Cells
      Daichi Onozato, Misaki Yamashita, Anna Nakanishi, Takumi Akagawa, Yuriko Kida, Isamu Ogawa, Tadahiro Hashita, Takahiro Iwao and Tamihide Matsunaga
      Drug Metabolism and Disposition November 2018, 46 (11) 1572-1580; DOI: https://doi.org/10.1124/dmd.118.080374
  3. Iyer, Ganesh R.

    1. You have access
      Models and Approaches Describing the Metabolism, Transport, and Toxicity of Drugs Administered by the Ocular Route
      Jennifer L. Dumouchel, Nagendra Chemuturi, Mark N. Milton, Gian Camenisch, James Chastain, Markus Walles, Vito Sasseville, Mithat Gunduz, Ganesh R. Iyer and Upendra A. Argikar
      Drug Metabolism and Disposition November 2018, 46 (11) 1670-1683; DOI: https://doi.org/10.1124/dmd.118.082974

J

  1. Jiraskova, Lucie

    1. You have access
      Equilibrative Nucleoside Transporter 1 (ENT1, SLC29A1) Facilitates Transfer of the Antiretroviral Drug Abacavir across the Placenta
      Lukas Cerveny, Zuzana Ptackova, Martina Ceckova, Rona Karahoda, Sara Karbanova, Lucie Jiraskova, Susan L. Greenwood, Jocelyn D. Glazier and Frantisek Staud
      Drug Metabolism and Disposition November 2018, 46 (11) 1817-1826; DOI: https://doi.org/10.1124/dmd.118.083329

K

  1. Kajitani, Naoyo

    1. You have access
      Characterization of P-Glycoprotein Humanized Mice Generated by Chromosome Engineering Technology: Its Utility for Prediction of Drug Distribution to the Brain in Humans
      Yuki Yamasaki, Kaoru Kobayashi, Fuka Okuya, Naoyo Kajitani, Kanako Kazuki, Satoshi Abe, Shoko Takehara, Shingo Ito, Seiryo Ogata, Tatsuki Uemura, Sumio Ohtsuki, Genki Minegishi, Hidetaka Akita, Kan Chiba, Mitsuo Oshimura and Yasuhiro Kazuki
      Drug Metabolism and Disposition November 2018, 46 (11) 1756-1766; DOI: https://doi.org/10.1124/dmd.118.081216
  2. Kanazu, Takushi

    1. You have access
      Application of Intestinal Epithelial Cells Differentiated from Human Induced Pluripotent Stem Cells for Studies of Prodrug Hydrolysis and Drug Absorption in the Small Intestine
      Takanori Akazawa, Shinpei Yoshida, Shuichi Ohnishi, Takushi Kanazu, Makoto Kawai and Koji Takahashi
      Drug Metabolism and Disposition November 2018, 46 (11) 1497-1506; DOI: https://doi.org/10.1124/dmd.118.083246
  3. Karahoda, Rona

    1. You have access
      Equilibrative Nucleoside Transporter 1 (ENT1, SLC29A1) Facilitates Transfer of the Antiretroviral Drug Abacavir across the Placenta
      Lukas Cerveny, Zuzana Ptackova, Martina Ceckova, Rona Karahoda, Sara Karbanova, Lucie Jiraskova, Susan L. Greenwood, Jocelyn D. Glazier and Frantisek Staud
      Drug Metabolism and Disposition November 2018, 46 (11) 1817-1826; DOI: https://doi.org/10.1124/dmd.118.083329
  4. Karbanova, Sara

    1. You have access
      Equilibrative Nucleoside Transporter 1 (ENT1, SLC29A1) Facilitates Transfer of the Antiretroviral Drug Abacavir across the Placenta
      Lukas Cerveny, Zuzana Ptackova, Martina Ceckova, Rona Karahoda, Sara Karbanova, Lucie Jiraskova, Susan L. Greenwood, Jocelyn D. Glazier and Frantisek Staud
      Drug Metabolism and Disposition November 2018, 46 (11) 1817-1826; DOI: https://doi.org/10.1124/dmd.118.083329
  5. Karlgren, M.

    1. Open Access
      CRISPR-Cas9: A New Addition to the Drug Metabolism and Disposition Tool Box
      M. Karlgren, I. Simoff, M. Keiser, S. Oswald and P. Artursson
      Drug Metabolism and Disposition November 2018, 46 (11) 1776-1786; DOI: https://doi.org/10.1124/dmd.118.082842
  6. Kasaian, Marion

    1. You have access
      Physiologically Relevant, Humanized Intestinal Systems to Study Metabolism and Transport of Small Molecule Therapeutics
      Aarti Sawant-Basak, A. David Rodrigues, Matthew Lech, Regis Doyonnas, Marion Kasaian, Bhagwat Prasad and Nikolaos Tsamandouras
      Drug Metabolism and Disposition November 2018, 46 (11) 1581-1587; DOI: https://doi.org/10.1124/dmd.118.082784
  7. Kawai, Makoto

    1. You have access
      Application of Intestinal Epithelial Cells Differentiated from Human Induced Pluripotent Stem Cells for Studies of Prodrug Hydrolysis and Drug Absorption in the Small Intestine
      Takanori Akazawa, Shinpei Yoshida, Shuichi Ohnishi, Takushi Kanazu, Makoto Kawai and Koji Takahashi
      Drug Metabolism and Disposition November 2018, 46 (11) 1497-1506; DOI: https://doi.org/10.1124/dmd.118.083246
  8. Kazuki, Kanako

    1. You have access
      Characterization of P-Glycoprotein Humanized Mice Generated by Chromosome Engineering Technology: Its Utility for Prediction of Drug Distribution to the Brain in Humans
      Yuki Yamasaki, Kaoru Kobayashi, Fuka Okuya, Naoyo Kajitani, Kanako Kazuki, Satoshi Abe, Shoko Takehara, Shingo Ito, Seiryo Ogata, Tatsuki Uemura, Sumio Ohtsuki, Genki Minegishi, Hidetaka Akita, Kan Chiba, Mitsuo Oshimura and Yasuhiro Kazuki
      Drug Metabolism and Disposition November 2018, 46 (11) 1756-1766; DOI: https://doi.org/10.1124/dmd.118.081216
  9. Kazuki, Yasuhiro

    1. You have access
      Characterization of P-Glycoprotein Humanized Mice Generated by Chromosome Engineering Technology: Its Utility for Prediction of Drug Distribution to the Brain in Humans
      Yuki Yamasaki, Kaoru Kobayashi, Fuka Okuya, Naoyo Kajitani, Kanako Kazuki, Satoshi Abe, Shoko Takehara, Shingo Ito, Seiryo Ogata, Tatsuki Uemura, Sumio Ohtsuki, Genki Minegishi, Hidetaka Akita, Kan Chiba, Mitsuo Oshimura and Yasuhiro Kazuki
      Drug Metabolism and Disposition November 2018, 46 (11) 1756-1766; DOI: https://doi.org/10.1124/dmd.118.081216
  10. Keiser, M.

    1. Open Access
      CRISPR-Cas9: A New Addition to the Drug Metabolism and Disposition Tool Box
      M. Karlgren, I. Simoff, M. Keiser, S. Oswald and P. Artursson
      Drug Metabolism and Disposition November 2018, 46 (11) 1776-1786; DOI: https://doi.org/10.1124/dmd.118.082842
  11. Kelly, Edward J.

    1. You have access
      Emerging Kidney Models to Investigate Metabolism, Transport, and Toxicity of Drugs and Xenobiotics
      Piyush Bajaj, Swapan K. Chowdhury, Robert Yucha, Edward J. Kelly and Guangqing Xiao
      Drug Metabolism and Disposition November 2018, 46 (11) 1692-1702; DOI: https://doi.org/10.1124/dmd.118.082958
  12. Kenna, J. Gerry

    1. Do In Vitro Assays Predict Drug Candidate Idiosyncratic Drug-Induced Liver Injury Risk?
      Open Access
      Do In Vitro Assays Predict Drug Candidate Idiosyncratic Drug-Induced Liver Injury Risk?
      J. Gerry Kenna and Jack Uetrecht
      Drug Metabolism and Disposition November 2018, 46 (11) 1658-1669; DOI: https://doi.org/10.1124/dmd.118.082719
  13. Khetani, Salman R.

    1. You have access
      Advances in Engineered Human Liver Platforms for Drug Metabolism Studies
      Gregory H. Underhill and Salman R. Khetani
      Drug Metabolism and Disposition November 2018, 46 (11) 1626-1637; DOI: https://doi.org/10.1124/dmd.118.083295
  14. Kida, Yuriko

    1. You have access
      Generation of Intestinal Organoids Suitable for Pharmacokinetic Studies from Human Induced Pluripotent Stem Cells
      Daichi Onozato, Misaki Yamashita, Anna Nakanishi, Takumi Akagawa, Yuriko Kida, Isamu Ogawa, Tadahiro Hashita, Takahiro Iwao and Tamihide Matsunaga
      Drug Metabolism and Disposition November 2018, 46 (11) 1572-1580; DOI: https://doi.org/10.1124/dmd.118.080374
  15. Knorpp, Thomas

    1. You have access
      Mouse Hepatomas with Ha-ras and B-raf Mutations Differ in Mitogen-Activated Protein Kinase Signaling and Response to Constitutive Androstane Receptor Activation
      Albert Braeuning, Ferdinand Kollotzek, Eva Zeller, Thomas Knorpp, Markus F. Templin and Michael Schwarz
      Drug Metabolism and Disposition November 2018, 46 (11) 1462-1465; DOI: https://doi.org/10.1124/dmd.118.083014
  16. Kobayashi, Kaoru

    1. You have access
      Characterization of P-Glycoprotein Humanized Mice Generated by Chromosome Engineering Technology: Its Utility for Prediction of Drug Distribution to the Brain in Humans
      Yuki Yamasaki, Kaoru Kobayashi, Fuka Okuya, Naoyo Kajitani, Kanako Kazuki, Satoshi Abe, Shoko Takehara, Shingo Ito, Seiryo Ogata, Tatsuki Uemura, Sumio Ohtsuki, Genki Minegishi, Hidetaka Akita, Kan Chiba, Mitsuo Oshimura and Yasuhiro Kazuki
      Drug Metabolism and Disposition November 2018, 46 (11) 1756-1766; DOI: https://doi.org/10.1124/dmd.118.081216
  17. Kolkhof, Peter

    1. Open Access
      Biotransformation of Finerenone, a Novel Nonsteroidal Mineralocorticoid Receptor Antagonist, in Dogs, Rats, and Humans, In Vivo and In Vitro
      Michael Gerisch, Roland Heinig, Anna Engelen, Dieter Lang, Peter Kolkhof, Martin Radtke, Johannes Platzek, Kai Lovis, Gabriele Rohde and Thomas Schwarz
      Drug Metabolism and Disposition November 2018, 46 (11) 1546-1555; DOI: https://doi.org/10.1124/dmd.118.083337
  18. Kollotzek, Ferdinand

    1. You have access
      Mouse Hepatomas with Ha-ras and B-raf Mutations Differ in Mitogen-Activated Protein Kinase Signaling and Response to Constitutive Androstane Receptor Activation
      Albert Braeuning, Ferdinand Kollotzek, Eva Zeller, Thomas Knorpp, Markus F. Templin and Michael Schwarz
      Drug Metabolism and Disposition November 2018, 46 (11) 1462-1465; DOI: https://doi.org/10.1124/dmd.118.083014
  19. Konagaya, Akihiko

    1. You have access
      Accurate Estimation of In Vivo Inhibition Constants of Inhibitors and Fraction Metabolized of Substrates with Physiologically Based Pharmacokinetic Drug–Drug Interaction Models Incorporating Parent Drugs and Metabolites of Substrates with Cluster Newton Method
      Kenta Yoshida, Kazuya Maeda, Akihiko Konagaya and Hiroyuki Kusuhara
      Drug Metabolism and Disposition November 2018, 46 (11) 1805-1816; DOI: https://doi.org/10.1124/dmd.118.081828
  20. Kovalchuk, Nataliia

    1. You have access
      P450-Humanized and Human Liver Chimeric Mouse Models for Studying Xenobiotic Metabolism and Toxicity
      Karl-Dimiter Bissig, Weiguo Han, Mercedes Barzi, Nataliia Kovalchuk, Liang Ding, Xiaoyu Fan, Francis P. Pankowicz, Qing-Yu Zhang and Xinxin Ding
      Drug Metabolism and Disposition November 2018, 46 (11) 1734-1744; DOI: https://doi.org/10.1124/dmd.118.083303
  21. Kusuhara, Hiroyuki

    1. You have access
      Evaluation of Organic Anion Transporter 1A2-knock-in Mice as a Model of Human Blood-brain Barrier
      Yamato Sano, Tadahaya Mizuno, Tatsuki Mochizuki, Yasuo Uchida, Mina Umetsu, Tetsuya Terasaki and Hiroyuki Kusuhara
      Drug Metabolism and Disposition November 2018, 46 (11) 1767-1775; DOI: https://doi.org/10.1124/dmd.118.081877
    2. You have access
      Accurate Estimation of In Vivo Inhibition Constants of Inhibitors and Fraction Metabolized of Substrates with Physiologically Based Pharmacokinetic Drug–Drug Interaction Models Incorporating Parent Drugs and Metabolites of Substrates with Cluster Newton Method
      Kenta Yoshida, Kazuya Maeda, Akihiko Konagaya and Hiroyuki Kusuhara
      Drug Metabolism and Disposition November 2018, 46 (11) 1805-1816; DOI: https://doi.org/10.1124/dmd.118.081828
  22. Kuypers, Dirk R. J.

    1. You have access
      Relationship between In Vivo CYP3A4 Activity, CYP3A5 Genotype, and Systemic Tacrolimus Metabolite/Parent Drug Ratio in Renal Transplant Recipients and Healthy Volunteers
      Thomas Vanhove, Hylke de Jonge, Henriëtte de Loor, Marlies Oorts, Jan de Hoon, Anton Pohanka, Pieter Annaert and Dirk R. J. Kuypers
      Drug Metabolism and Disposition November 2018, 46 (11) 1507-1513; DOI: https://doi.org/10.1124/dmd.118.081935

L

  1. Lang, Dieter

    1. Open Access
      Biotransformation of Finerenone, a Novel Nonsteroidal Mineralocorticoid Receptor Antagonist, in Dogs, Rats, and Humans, In Vivo and In Vitro
      Michael Gerisch, Roland Heinig, Anna Engelen, Dieter Lang, Peter Kolkhof, Martin Radtke, Johannes Platzek, Kai Lovis, Gabriele Rohde and Thomas Schwarz
      Drug Metabolism and Disposition November 2018, 46 (11) 1546-1555; DOI: https://doi.org/10.1124/dmd.118.083337
  2. Lech, Matthew

    1. You have access
      Physiologically Relevant, Humanized Intestinal Systems to Study Metabolism and Transport of Small Molecule Therapeutics
      Aarti Sawant-Basak, A. David Rodrigues, Matthew Lech, Regis Doyonnas, Marion Kasaian, Bhagwat Prasad and Nikolaos Tsamandouras
      Drug Metabolism and Disposition November 2018, 46 (11) 1581-1587; DOI: https://doi.org/10.1124/dmd.118.082784
  3. Lee, Ping I.

    1. You have access
      Finding Tmax and Cmax in Multicompartmental Models
      Yi Rang Han, Ping I. Lee and K. Sandy Pang
      Drug Metabolism and Disposition November 2018, 46 (11) 1796-1804; DOI: https://doi.org/10.1124/dmd.118.082636
  4. Li, Albert P.

    1. You have access
      A Novel In Vitro Experimental System for the Evaluation of Drug Metabolism: Cofactor-Supplemented Permeabilized Cryopreserved Human Hepatocytes (MetMax Cryopreserved Human Hepatocytes)
      Albert P. Li, Ming-Chih David Ho, Kirsten Amaral and Carol Loretz
      Drug Metabolism and Disposition November 2018, 46 (11) 1608-1616; DOI: https://doi.org/10.1124/dmd.117.079657
    2. You have access
      Cryopreserved Human Intestinal Mucosal Epithelium: A Novel In Vitro Experimental System for the Evaluation of Enteric Drug Metabolism, Cytochrome P450 Induction, and Enterotoxicity
      Albert P. Li, Novera Alam, Kirsten Amaral, Ming-Chih David Ho, Carol Loretz, Walter Mitchell and Qian Yang
      Drug Metabolism and Disposition November 2018, 46 (11) 1562-1571; DOI: https://doi.org/10.1124/dmd.118.082875
  5. Li, Hui

    1. You have access
      Gene-by-Environment Interaction of Bcrp−/− and Methionine- and Choline-Deficient Diet–Induced Nonalcoholic Steatohepatitis Alters SN-38 Disposition
      Erica L. Toth, Hui Li, Anika L. Dzierlenga, John D. Clarke, Anna Vildhede, Michael Goedken and Nathan J. Cherrington
      Drug Metabolism and Disposition November 2018, 46 (11) 1478-1486; DOI: https://doi.org/10.1124/dmd.118.082081
  6. Lombardo, Franco

    1. You have access
      Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds
      Franco Lombardo, Giuliano Berellini and R. Scott Obach
      Drug Metabolism and Disposition November 2018, 46 (11) 1466-1477; DOI: https://doi.org/10.1124/dmd.118.082966
  7. Loretz, Carol

    1. You have access
      A Novel In Vitro Experimental System for the Evaluation of Drug Metabolism: Cofactor-Supplemented Permeabilized Cryopreserved Human Hepatocytes (MetMax Cryopreserved Human Hepatocytes)
      Albert P. Li, Ming-Chih David Ho, Kirsten Amaral and Carol Loretz
      Drug Metabolism and Disposition November 2018, 46 (11) 1608-1616; DOI: https://doi.org/10.1124/dmd.117.079657
    2. You have access
      Cryopreserved Human Intestinal Mucosal Epithelium: A Novel In Vitro Experimental System for the Evaluation of Enteric Drug Metabolism, Cytochrome P450 Induction, and Enterotoxicity
      Albert P. Li, Novera Alam, Kirsten Amaral, Ming-Chih David Ho, Carol Loretz, Walter Mitchell and Qian Yang
      Drug Metabolism and Disposition November 2018, 46 (11) 1562-1571; DOI: https://doi.org/10.1124/dmd.118.082875
  8. Lovis, Kai

    1. Open Access
      Biotransformation of Finerenone, a Novel Nonsteroidal Mineralocorticoid Receptor Antagonist, in Dogs, Rats, and Humans, In Vivo and In Vitro
      Michael Gerisch, Roland Heinig, Anna Engelen, Dieter Lang, Peter Kolkhof, Martin Radtke, Johannes Platzek, Kai Lovis, Gabriele Rohde and Thomas Schwarz
      Drug Metabolism and Disposition November 2018, 46 (11) 1546-1555; DOI: https://doi.org/10.1124/dmd.118.083337

M

  1. Maeda, Kazuya

    1. You have access
      Accurate Estimation of In Vivo Inhibition Constants of Inhibitors and Fraction Metabolized of Substrates with Physiologically Based Pharmacokinetic Drug–Drug Interaction Models Incorporating Parent Drugs and Metabolites of Substrates with Cluster Newton Method
      Kenta Yoshida, Kazuya Maeda, Akihiko Konagaya and Hiroyuki Kusuhara
      Drug Metabolism and Disposition November 2018, 46 (11) 1805-1816; DOI: https://doi.org/10.1124/dmd.118.081828
  2. Marini, Federico

    1. You have access
      Health-Relevant Phenotypes in the Offspring of Mice Given CAR Activators Prior to Pregnancy
      Karin Dietrich, Jan Baumgart, Leonid Eshkind, Lea Reuter, Ute Gödtel-Armbrust, Elke Butt, Michael Musheev, Federico Marini, Piyush More, Tanja Grosser, Christof Niehrs, Leszek Wojnowski and Marianne Mathäs
      Drug Metabolism and Disposition November 2018, 46 (11) 1827-1835; DOI: https://doi.org/10.1124/dmd.118.082925
  3. Mast, Natalia

    1. Retinal Cholesterol Content Is Reduced in Simvastatin-Treated Mice Due to Inhibited Local Biosynthesis Albeit Increased Uptake of Serum Cholesterol
      You have access
      Retinal Cholesterol Content Is Reduced in Simvastatin-Treated Mice Due to Inhibited Local Biosynthesis Albeit Increased Uptake of Serum Cholesterol
      Natalia Mast, Ilya R. Bederman and Irina A. Pikuleva
      Drug Metabolism and Disposition November 2018, 46 (11) 1528-1537; DOI: https://doi.org/10.1124/dmd.118.083345
  4. Mathäs, Marianne

    1. You have access
      Health-Relevant Phenotypes in the Offspring of Mice Given CAR Activators Prior to Pregnancy
      Karin Dietrich, Jan Baumgart, Leonid Eshkind, Lea Reuter, Ute Gödtel-Armbrust, Elke Butt, Michael Musheev, Federico Marini, Piyush More, Tanja Grosser, Christof Niehrs, Leszek Wojnowski and Marianne Mathäs
      Drug Metabolism and Disposition November 2018, 46 (11) 1827-1835; DOI: https://doi.org/10.1124/dmd.118.082925
  5. Mathialagan, Sumathy

    1. You have access
      Human Pluripotent Stem Cell–Derived Kidney Model for Nephrotoxicity Studies
      Piyush Bajaj, A. David Rodrigues, Claire M. Steppan, Sandra J. Engle, Sumathy Mathialagan and Thomas Schroeter
      Drug Metabolism and Disposition November 2018, 46 (11) 1703-1711; DOI: https://doi.org/10.1124/dmd.118.082727
  6. Matsunaga, Tamihide

    1. You have access
      Effect of Celecoxib on Differentiation of Human Induced Pluripotent Stem Cells into Hepatocytes Involves STAT5 Activation
      Hiroki Okumura, Anna Nakanishi, Tadahiro Hashita, Takahiro Iwao and Tamihide Matsunaga
      Drug Metabolism and Disposition November 2018, 46 (11) 1519-1527; DOI: https://doi.org/10.1124/dmd.118.082982
    2. You have access
      Generation of Intestinal Organoids Suitable for Pharmacokinetic Studies from Human Induced Pluripotent Stem Cells
      Daichi Onozato, Misaki Yamashita, Anna Nakanishi, Takumi Akagawa, Yuriko Kida, Isamu Ogawa, Tadahiro Hashita, Takahiro Iwao and Tamihide Matsunaga
      Drug Metabolism and Disposition November 2018, 46 (11) 1572-1580; DOI: https://doi.org/10.1124/dmd.118.080374
  7. Mayersohn, Michael

    1. You have access
      Porcine Prediction of Pharmacokinetic Parameters in People: A Pig in a Poke?
      Huadong Tang and Michael Mayersohn
      Drug Metabolism and Disposition November 2018, 46 (11) 1712-1724; DOI: https://doi.org/10.1124/dmd.118.083311
  8. Mehvar, Reza

    1. You have access
      Brain Uptake of [13C] and [14C]Sucrose Quantified by Microdialysis and Whole Tissue Analysis in Mice
      Faleh Alqahtani, Ekram Ahmed Chowdhury, Raktima Bhattacharya, Behnam Noorani, Reza Mehvar and Ulrich Bickel
      Drug Metabolism and Disposition November 2018, 46 (11) 1514-1518; DOI: https://doi.org/10.1124/dmd.118.082909
  9. Milton, Mark N.

    1. You have access
      Models and Approaches Describing the Metabolism, Transport, and Toxicity of Drugs Administered by the Ocular Route
      Jennifer L. Dumouchel, Nagendra Chemuturi, Mark N. Milton, Gian Camenisch, James Chastain, Markus Walles, Vito Sasseville, Mithat Gunduz, Ganesh R. Iyer and Upendra A. Argikar
      Drug Metabolism and Disposition November 2018, 46 (11) 1670-1683; DOI: https://doi.org/10.1124/dmd.118.082974
  10. Minegishi, Genki

    1. You have access
      Characterization of P-Glycoprotein Humanized Mice Generated by Chromosome Engineering Technology: Its Utility for Prediction of Drug Distribution to the Brain in Humans
      Yuki Yamasaki, Kaoru Kobayashi, Fuka Okuya, Naoyo Kajitani, Kanako Kazuki, Satoshi Abe, Shoko Takehara, Shingo Ito, Seiryo Ogata, Tatsuki Uemura, Sumio Ohtsuki, Genki Minegishi, Hidetaka Akita, Kan Chiba, Mitsuo Oshimura and Yasuhiro Kazuki
      Drug Metabolism and Disposition November 2018, 46 (11) 1756-1766; DOI: https://doi.org/10.1124/dmd.118.081216
  11. Mitchell, Walter

    1. You have access
      Cryopreserved Human Intestinal Mucosal Epithelium: A Novel In Vitro Experimental System for the Evaluation of Enteric Drug Metabolism, Cytochrome P450 Induction, and Enterotoxicity
      Albert P. Li, Novera Alam, Kirsten Amaral, Ming-Chih David Ho, Carol Loretz, Walter Mitchell and Qian Yang
      Drug Metabolism and Disposition November 2018, 46 (11) 1562-1571; DOI: https://doi.org/10.1124/dmd.118.082875
  12. Mizuno, Tadahaya

    1. You have access
      Evaluation of Organic Anion Transporter 1A2-knock-in Mice as a Model of Human Blood-brain Barrier
      Yamato Sano, Tadahaya Mizuno, Tatsuki Mochizuki, Yasuo Uchida, Mina Umetsu, Tetsuya Terasaki and Hiroyuki Kusuhara
      Drug Metabolism and Disposition November 2018, 46 (11) 1767-1775; DOI: https://doi.org/10.1124/dmd.118.081877
  13. Mochizuki, Tatsuki

    1. You have access
      Evaluation of Organic Anion Transporter 1A2-knock-in Mice as a Model of Human Blood-brain Barrier
      Yamato Sano, Tadahaya Mizuno, Tatsuki Mochizuki, Yasuo Uchida, Mina Umetsu, Tetsuya Terasaki and Hiroyuki Kusuhara
      Drug Metabolism and Disposition November 2018, 46 (11) 1767-1775; DOI: https://doi.org/10.1124/dmd.118.081877
  14. More, Piyush

    1. You have access
      Health-Relevant Phenotypes in the Offspring of Mice Given CAR Activators Prior to Pregnancy
      Karin Dietrich, Jan Baumgart, Leonid Eshkind, Lea Reuter, Ute Gödtel-Armbrust, Elke Butt, Michael Musheev, Federico Marini, Piyush More, Tanja Grosser, Christof Niehrs, Leszek Wojnowski and Marianne Mathäs
      Drug Metabolism and Disposition November 2018, 46 (11) 1827-1835; DOI: https://doi.org/10.1124/dmd.118.082925
  15. Mosedale, Merrie

    1. You have access
      Mouse Population-Based Approaches to Investigate Adverse Drug Reactions
      Merrie Mosedale
      Drug Metabolism and Disposition November 2018, 46 (11) 1787-1795; DOI: https://doi.org/10.1124/dmd.118.082834
  16. Musheev, Michael

    1. You have access
      Health-Relevant Phenotypes in the Offspring of Mice Given CAR Activators Prior to Pregnancy
      Karin Dietrich, Jan Baumgart, Leonid Eshkind, Lea Reuter, Ute Gödtel-Armbrust, Elke Butt, Michael Musheev, Federico Marini, Piyush More, Tanja Grosser, Christof Niehrs, Leszek Wojnowski and Marianne Mathäs
      Drug Metabolism and Disposition November 2018, 46 (11) 1827-1835; DOI: https://doi.org/10.1124/dmd.118.082925

N

  1. Nakanishi, Anna

    1. You have access
      Effect of Celecoxib on Differentiation of Human Induced Pluripotent Stem Cells into Hepatocytes Involves STAT5 Activation
      Hiroki Okumura, Anna Nakanishi, Tadahiro Hashita, Takahiro Iwao and Tamihide Matsunaga
      Drug Metabolism and Disposition November 2018, 46 (11) 1519-1527; DOI: https://doi.org/10.1124/dmd.118.082982
    2. You have access
      Generation of Intestinal Organoids Suitable for Pharmacokinetic Studies from Human Induced Pluripotent Stem Cells
      Daichi Onozato, Misaki Yamashita, Anna Nakanishi, Takumi Akagawa, Yuriko Kida, Isamu Ogawa, Tadahiro Hashita, Takahiro Iwao and Tamihide Matsunaga
      Drug Metabolism and Disposition November 2018, 46 (11) 1572-1580; DOI: https://doi.org/10.1124/dmd.118.080374
  2. Niehrs, Christof

    1. You have access
      Health-Relevant Phenotypes in the Offspring of Mice Given CAR Activators Prior to Pregnancy
      Karin Dietrich, Jan Baumgart, Leonid Eshkind, Lea Reuter, Ute Gödtel-Armbrust, Elke Butt, Michael Musheev, Federico Marini, Piyush More, Tanja Grosser, Christof Niehrs, Leszek Wojnowski and Marianne Mathäs
      Drug Metabolism and Disposition November 2018, 46 (11) 1827-1835; DOI: https://doi.org/10.1124/dmd.118.082925
  3. Nooijen, I. H. G.

    1. You have access
      An Ex Vivo Fermentation Screening Platform to Study Drug Metabolism by Human Gut Microbiota
      E. van de Steeg, F. H. J. Schuren, R. Scott Obach, C. van Woudenbergh, Gregory S. Walker, M. Heerikhuisen, I. H. G. Nooijen and W. H. J. Vaes
      Drug Metabolism and Disposition November 2018, 46 (11) 1596-1607; DOI: https://doi.org/10.1124/dmd.118.081026
  4. Noorani, Behnam

    1. You have access
      Brain Uptake of [13C] and [14C]Sucrose Quantified by Microdialysis and Whole Tissue Analysis in Mice
      Faleh Alqahtani, Ekram Ahmed Chowdhury, Raktima Bhattacharya, Behnam Noorani, Reza Mehvar and Ulrich Bickel
      Drug Metabolism and Disposition November 2018, 46 (11) 1514-1518; DOI: https://doi.org/10.1124/dmd.118.082909

O

  1. Obach, R. Scott

    1. You have access
      Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds
      Franco Lombardo, Giuliano Berellini and R. Scott Obach
      Drug Metabolism and Disposition November 2018, 46 (11) 1466-1477; DOI: https://doi.org/10.1124/dmd.118.082966
    2. You have access
      An Ex Vivo Fermentation Screening Platform to Study Drug Metabolism by Human Gut Microbiota
      E. van de Steeg, F. H. J. Schuren, R. Scott Obach, C. van Woudenbergh, Gregory S. Walker, M. Heerikhuisen, I. H. G. Nooijen and W. H. J. Vaes
      Drug Metabolism and Disposition November 2018, 46 (11) 1596-1607; DOI: https://doi.org/10.1124/dmd.118.081026
    3. You have access
      Emerging Models of Drug Metabolism, Transporters, and Toxicity
      Aarti Sawant-Basak and R. Scott Obach
      Drug Metabolism and Disposition November 2018, 46 (11) 1556-1561; DOI: https://doi.org/10.1124/dmd.118.084293
  2. Ogata, Seiryo

    1. You have access
      Characterization of P-Glycoprotein Humanized Mice Generated by Chromosome Engineering Technology: Its Utility for Prediction of Drug Distribution to the Brain in Humans
      Yuki Yamasaki, Kaoru Kobayashi, Fuka Okuya, Naoyo Kajitani, Kanako Kazuki, Satoshi Abe, Shoko Takehara, Shingo Ito, Seiryo Ogata, Tatsuki Uemura, Sumio Ohtsuki, Genki Minegishi, Hidetaka Akita, Kan Chiba, Mitsuo Oshimura and Yasuhiro Kazuki
      Drug Metabolism and Disposition November 2018, 46 (11) 1756-1766; DOI: https://doi.org/10.1124/dmd.118.081216
  3. Ogawa, Isamu

    1. You have access
      Generation of Intestinal Organoids Suitable for Pharmacokinetic Studies from Human Induced Pluripotent Stem Cells
      Daichi Onozato, Misaki Yamashita, Anna Nakanishi, Takumi Akagawa, Yuriko Kida, Isamu Ogawa, Tadahiro Hashita, Takahiro Iwao and Tamihide Matsunaga
      Drug Metabolism and Disposition November 2018, 46 (11) 1572-1580; DOI: https://doi.org/10.1124/dmd.118.080374
  4. Ohnishi, Shuichi

    1. You have access
      Application of Intestinal Epithelial Cells Differentiated from Human Induced Pluripotent Stem Cells for Studies of Prodrug Hydrolysis and Drug Absorption in the Small Intestine
      Takanori Akazawa, Shinpei Yoshida, Shuichi Ohnishi, Takushi Kanazu, Makoto Kawai and Koji Takahashi
      Drug Metabolism and Disposition November 2018, 46 (11) 1497-1506; DOI: https://doi.org/10.1124/dmd.118.083246
  5. Ohtsuki, Sumio

    1. You have access
      Characterization of P-Glycoprotein Humanized Mice Generated by Chromosome Engineering Technology: Its Utility for Prediction of Drug Distribution to the Brain in Humans
      Yuki Yamasaki, Kaoru Kobayashi, Fuka Okuya, Naoyo Kajitani, Kanako Kazuki, Satoshi Abe, Shoko Takehara, Shingo Ito, Seiryo Ogata, Tatsuki Uemura, Sumio Ohtsuki, Genki Minegishi, Hidetaka Akita, Kan Chiba, Mitsuo Oshimura and Yasuhiro Kazuki
      Drug Metabolism and Disposition November 2018, 46 (11) 1756-1766; DOI: https://doi.org/10.1124/dmd.118.081216
  6. Okumura, Hiroki

    1. You have access
      Effect of Celecoxib on Differentiation of Human Induced Pluripotent Stem Cells into Hepatocytes Involves STAT5 Activation
      Hiroki Okumura, Anna Nakanishi, Tadahiro Hashita, Takahiro Iwao and Tamihide Matsunaga
      Drug Metabolism and Disposition November 2018, 46 (11) 1519-1527; DOI: https://doi.org/10.1124/dmd.118.082982
  7. Okuya, Fuka

    1. You have access
      Characterization of P-Glycoprotein Humanized Mice Generated by Chromosome Engineering Technology: Its Utility for Prediction of Drug Distribution to the Brain in Humans
      Yuki Yamasaki, Kaoru Kobayashi, Fuka Okuya, Naoyo Kajitani, Kanako Kazuki, Satoshi Abe, Shoko Takehara, Shingo Ito, Seiryo Ogata, Tatsuki Uemura, Sumio Ohtsuki, Genki Minegishi, Hidetaka Akita, Kan Chiba, Mitsuo Oshimura and Yasuhiro Kazuki
      Drug Metabolism and Disposition November 2018, 46 (11) 1756-1766; DOI: https://doi.org/10.1124/dmd.118.081216
  8. Onozato, Daichi

    1. You have access
      Generation of Intestinal Organoids Suitable for Pharmacokinetic Studies from Human Induced Pluripotent Stem Cells
      Daichi Onozato, Misaki Yamashita, Anna Nakanishi, Takumi Akagawa, Yuriko Kida, Isamu Ogawa, Tadahiro Hashita, Takahiro Iwao and Tamihide Matsunaga
      Drug Metabolism and Disposition November 2018, 46 (11) 1572-1580; DOI: https://doi.org/10.1124/dmd.118.080374
  9. Oorts, Marlies

    1. You have access
      Relationship between In Vivo CYP3A4 Activity, CYP3A5 Genotype, and Systemic Tacrolimus Metabolite/Parent Drug Ratio in Renal Transplant Recipients and Healthy Volunteers
      Thomas Vanhove, Hylke de Jonge, Henriëtte de Loor, Marlies Oorts, Jan de Hoon, Anton Pohanka, Pieter Annaert and Dirk R. J. Kuypers
      Drug Metabolism and Disposition November 2018, 46 (11) 1507-1513; DOI: https://doi.org/10.1124/dmd.118.081935
  10. Oshimura, Mitsuo

    1. You have access
      Characterization of P-Glycoprotein Humanized Mice Generated by Chromosome Engineering Technology: Its Utility for Prediction of Drug Distribution to the Brain in Humans
      Yuki Yamasaki, Kaoru Kobayashi, Fuka Okuya, Naoyo Kajitani, Kanako Kazuki, Satoshi Abe, Shoko Takehara, Shingo Ito, Seiryo Ogata, Tatsuki Uemura, Sumio Ohtsuki, Genki Minegishi, Hidetaka Akita, Kan Chiba, Mitsuo Oshimura and Yasuhiro Kazuki
      Drug Metabolism and Disposition November 2018, 46 (11) 1756-1766; DOI: https://doi.org/10.1124/dmd.118.081216
  11. Oswald, S.

    1. Open Access
      CRISPR-Cas9: A New Addition to the Drug Metabolism and Disposition Tool Box
      M. Karlgren, I. Simoff, M. Keiser, S. Oswald and P. Artursson
      Drug Metabolism and Disposition November 2018, 46 (11) 1776-1786; DOI: https://doi.org/10.1124/dmd.118.082842

P

  1. Pang, K. Sandy

    1. You have access
      Finding Tmax and Cmax in Multicompartmental Models
      Yi Rang Han, Ping I. Lee and K. Sandy Pang
      Drug Metabolism and Disposition November 2018, 46 (11) 1796-1804; DOI: https://doi.org/10.1124/dmd.118.082636
  2. Pankowicz, Francis P.

    1. You have access
      P450-Humanized and Human Liver Chimeric Mouse Models for Studying Xenobiotic Metabolism and Toxicity
      Karl-Dimiter Bissig, Weiguo Han, Mercedes Barzi, Nataliia Kovalchuk, Liang Ding, Xiaoyu Fan, Francis P. Pankowicz, Qing-Yu Zhang and Xinxin Ding
      Drug Metabolism and Disposition November 2018, 46 (11) 1734-1744; DOI: https://doi.org/10.1124/dmd.118.083303
  3. Patilea-Vrana, Gabriela I.

    1. You have access
      When Does the Rate-Determining Step in the Hepatic Clearance of a Drug Switch from Sinusoidal Uptake to All Hepatobiliary Clearances? Implications for Predicting Drug-Drug Interactions
      Gabriela I. Patilea-Vrana and Jashvant D. Unadkat
      Drug Metabolism and Disposition November 2018, 46 (11) 1487-1496; DOI: https://doi.org/10.1124/dmd.118.081307
  4. Pieper, Lindsey M.

    1. You have access
      How to Determine the Role of the Microbiome in Drug Disposition
      Jordan E. Bisanz, Peter Spanogiannopoulos, Lindsey M. Pieper, Annamarie E. Bustion and Peter J. Turnbaugh
      Drug Metabolism and Disposition November 2018, 46 (11) 1588-1595; DOI: https://doi.org/10.1124/dmd.118.083402
  5. Pikuleva, Irina A.

    1. Retinal Cholesterol Content Is Reduced in Simvastatin-Treated Mice Due to Inhibited Local Biosynthesis Albeit Increased Uptake of Serum Cholesterol
      You have access
      Retinal Cholesterol Content Is Reduced in Simvastatin-Treated Mice Due to Inhibited Local Biosynthesis Albeit Increased Uptake of Serum Cholesterol
      Natalia Mast, Ilya R. Bederman and Irina A. Pikuleva
      Drug Metabolism and Disposition November 2018, 46 (11) 1528-1537; DOI: https://doi.org/10.1124/dmd.118.083345
  6. Platzek, Johannes

    1. Open Access
      Biotransformation of Finerenone, a Novel Nonsteroidal Mineralocorticoid Receptor Antagonist, in Dogs, Rats, and Humans, In Vivo and In Vitro
      Michael Gerisch, Roland Heinig, Anna Engelen, Dieter Lang, Peter Kolkhof, Martin Radtke, Johannes Platzek, Kai Lovis, Gabriele Rohde and Thomas Schwarz
      Drug Metabolism and Disposition November 2018, 46 (11) 1546-1555; DOI: https://doi.org/10.1124/dmd.118.083337
  7. Pohanka, Anton

    1. You have access
      Relationship between In Vivo CYP3A4 Activity, CYP3A5 Genotype, and Systemic Tacrolimus Metabolite/Parent Drug Ratio in Renal Transplant Recipients and Healthy Volunteers
      Thomas Vanhove, Hylke de Jonge, Henriëtte de Loor, Marlies Oorts, Jan de Hoon, Anton Pohanka, Pieter Annaert and Dirk R. J. Kuypers
      Drug Metabolism and Disposition November 2018, 46 (11) 1507-1513; DOI: https://doi.org/10.1124/dmd.118.081935
  8. Prasad, Bhagwat

    1. You have access
      Physiologically Relevant, Humanized Intestinal Systems to Study Metabolism and Transport of Small Molecule Therapeutics
      Aarti Sawant-Basak, A. David Rodrigues, Matthew Lech, Regis Doyonnas, Marion Kasaian, Bhagwat Prasad and Nikolaos Tsamandouras
      Drug Metabolism and Disposition November 2018, 46 (11) 1581-1587; DOI: https://doi.org/10.1124/dmd.118.082784
  9. Ptackova, Zuzana

    1. You have access
      Equilibrative Nucleoside Transporter 1 (ENT1, SLC29A1) Facilitates Transfer of the Antiretroviral Drug Abacavir across the Placenta
      Lukas Cerveny, Zuzana Ptackova, Martina Ceckova, Rona Karahoda, Sara Karbanova, Lucie Jiraskova, Susan L. Greenwood, Jocelyn D. Glazier and Frantisek Staud
      Drug Metabolism and Disposition November 2018, 46 (11) 1817-1826; DOI: https://doi.org/10.1124/dmd.118.083329

R

  1. Radtke, Martin

    1. Open Access
      Biotransformation of Finerenone, a Novel Nonsteroidal Mineralocorticoid Receptor Antagonist, in Dogs, Rats, and Humans, In Vivo and In Vitro
      Michael Gerisch, Roland Heinig, Anna Engelen, Dieter Lang, Peter Kolkhof, Martin Radtke, Johannes Platzek, Kai Lovis, Gabriele Rohde and Thomas Schwarz
      Drug Metabolism and Disposition November 2018, 46 (11) 1546-1555; DOI: https://doi.org/10.1124/dmd.118.083337
  2. Reuter, Lea

    1. You have access
      Health-Relevant Phenotypes in the Offspring of Mice Given CAR Activators Prior to Pregnancy
      Karin Dietrich, Jan Baumgart, Leonid Eshkind, Lea Reuter, Ute Gödtel-Armbrust, Elke Butt, Michael Musheev, Federico Marini, Piyush More, Tanja Grosser, Christof Niehrs, Leszek Wojnowski and Marianne Mathäs
      Drug Metabolism and Disposition November 2018, 46 (11) 1827-1835; DOI: https://doi.org/10.1124/dmd.118.082925
  3. Rodrigues, A. David

    1. You have access
      Human Pluripotent Stem Cell–Derived Kidney Model for Nephrotoxicity Studies
      Piyush Bajaj, A. David Rodrigues, Claire M. Steppan, Sandra J. Engle, Sumathy Mathialagan and Thomas Schroeter
      Drug Metabolism and Disposition November 2018, 46 (11) 1703-1711; DOI: https://doi.org/10.1124/dmd.118.082727
    2. You have access
      Physiologically Relevant, Humanized Intestinal Systems to Study Metabolism and Transport of Small Molecule Therapeutics
      Aarti Sawant-Basak, A. David Rodrigues, Matthew Lech, Regis Doyonnas, Marion Kasaian, Bhagwat Prasad and Nikolaos Tsamandouras
      Drug Metabolism and Disposition November 2018, 46 (11) 1581-1587; DOI: https://doi.org/10.1124/dmd.118.082784
  4. Rohde, Gabriele

    1. Open Access
      Biotransformation of Finerenone, a Novel Nonsteroidal Mineralocorticoid Receptor Antagonist, in Dogs, Rats, and Humans, In Vivo and In Vitro
      Michael Gerisch, Roland Heinig, Anna Engelen, Dieter Lang, Peter Kolkhof, Martin Radtke, Johannes Platzek, Kai Lovis, Gabriele Rohde and Thomas Schwarz
      Drug Metabolism and Disposition November 2018, 46 (11) 1546-1555; DOI: https://doi.org/10.1124/dmd.118.083337

S

  1. Sano, Yamato

    1. You have access
      Evaluation of Organic Anion Transporter 1A2-knock-in Mice as a Model of Human Blood-brain Barrier
      Yamato Sano, Tadahaya Mizuno, Tatsuki Mochizuki, Yasuo Uchida, Mina Umetsu, Tetsuya Terasaki and Hiroyuki Kusuhara
      Drug Metabolism and Disposition November 2018, 46 (11) 1767-1775; DOI: https://doi.org/10.1124/dmd.118.081877
  2. Sasseville, Vito

    1. You have access
      Models and Approaches Describing the Metabolism, Transport, and Toxicity of Drugs Administered by the Ocular Route
      Jennifer L. Dumouchel, Nagendra Chemuturi, Mark N. Milton, Gian Camenisch, James Chastain, Markus Walles, Vito Sasseville, Mithat Gunduz, Ganesh R. Iyer and Upendra A. Argikar
      Drug Metabolism and Disposition November 2018, 46 (11) 1670-1683; DOI: https://doi.org/10.1124/dmd.118.082974
  3. Sawant-Basak, Aarti

    1. You have access
      Physiologically Relevant, Humanized Intestinal Systems to Study Metabolism and Transport of Small Molecule Therapeutics
      Aarti Sawant-Basak, A. David Rodrigues, Matthew Lech, Regis Doyonnas, Marion Kasaian, Bhagwat Prasad and Nikolaos Tsamandouras
      Drug Metabolism and Disposition November 2018, 46 (11) 1581-1587; DOI: https://doi.org/10.1124/dmd.118.082784
    2. You have access
      Emerging Models of Drug Metabolism, Transporters, and Toxicity
      Aarti Sawant-Basak and R. Scott Obach
      Drug Metabolism and Disposition November 2018, 46 (11) 1556-1561; DOI: https://doi.org/10.1124/dmd.118.084293
  4. Schroeter, Thomas

    1. You have access
      Human Pluripotent Stem Cell–Derived Kidney Model for Nephrotoxicity Studies
      Piyush Bajaj, A. David Rodrigues, Claire M. Steppan, Sandra J. Engle, Sumathy Mathialagan and Thomas Schroeter
      Drug Metabolism and Disposition November 2018, 46 (11) 1703-1711; DOI: https://doi.org/10.1124/dmd.118.082727
  5. Schuetz, Erin G.

    1. Pheophorbide A: Fluorescent Bcrp Substrate to Measure Oral Drug-Drug Interactions in Real-Time In Vivo
      You have access
      Pheophorbide A: Fluorescent Bcrp Substrate to Measure Oral Drug-Drug Interactions in Real-Time In Vivo
      Kazuto Yasuda, Samit Ganguly and Erin G. Schuetz
      Drug Metabolism and Disposition November 2018, 46 (11) 1725-1733; DOI: https://doi.org/10.1124/dmd.118.083584
  6. Schuren, F. H. J.

    1. You have access
      An Ex Vivo Fermentation Screening Platform to Study Drug Metabolism by Human Gut Microbiota
      E. van de Steeg, F. H. J. Schuren, R. Scott Obach, C. van Woudenbergh, Gregory S. Walker, M. Heerikhuisen, I. H. G. Nooijen and W. H. J. Vaes
      Drug Metabolism and Disposition November 2018, 46 (11) 1596-1607; DOI: https://doi.org/10.1124/dmd.118.081026
  7. Schwarz, Michael

    1. You have access
      Mouse Hepatomas with Ha-ras and B-raf Mutations Differ in Mitogen-Activated Protein Kinase Signaling and Response to Constitutive Androstane Receptor Activation
      Albert Braeuning, Ferdinand Kollotzek, Eva Zeller, Thomas Knorpp, Markus F. Templin and Michael Schwarz
      Drug Metabolism and Disposition November 2018, 46 (11) 1462-1465; DOI: https://doi.org/10.1124/dmd.118.083014
  8. Schwarz, Thomas

    1. Open Access
      Biotransformation of Finerenone, a Novel Nonsteroidal Mineralocorticoid Receptor Antagonist, in Dogs, Rats, and Humans, In Vivo and In Vitro
      Michael Gerisch, Roland Heinig, Anna Engelen, Dieter Lang, Peter Kolkhof, Martin Radtke, Johannes Platzek, Kai Lovis, Gabriele Rohde and Thomas Schwarz
      Drug Metabolism and Disposition November 2018, 46 (11) 1546-1555; DOI: https://doi.org/10.1124/dmd.118.083337
  9. Simoff, I.

    1. Open Access
      CRISPR-Cas9: A New Addition to the Drug Metabolism and Disposition Tool Box
      M. Karlgren, I. Simoff, M. Keiser, S. Oswald and P. Artursson
      Drug Metabolism and Disposition November 2018, 46 (11) 1776-1786; DOI: https://doi.org/10.1124/dmd.118.082842
  10. Spanogiannopoulos, Peter

    1. You have access
      How to Determine the Role of the Microbiome in Drug Disposition
      Jordan E. Bisanz, Peter Spanogiannopoulos, Lindsey M. Pieper, Annamarie E. Bustion and Peter J. Turnbaugh
      Drug Metabolism and Disposition November 2018, 46 (11) 1588-1595; DOI: https://doi.org/10.1124/dmd.118.083402
  11. Stahl, Simone H.

    1. You have access
      Perspective on the Application of Microphysiological Systems to Drug Transporter Studies
      Pedro Caetano-Pinto and Simone H. Stahl
      Drug Metabolism and Disposition November 2018, 46 (11) 1647-1657; DOI: https://doi.org/10.1124/dmd.118.082750
  12. Staud, Frantisek

    1. You have access
      Equilibrative Nucleoside Transporter 1 (ENT1, SLC29A1) Facilitates Transfer of the Antiretroviral Drug Abacavir across the Placenta
      Lukas Cerveny, Zuzana Ptackova, Martina Ceckova, Rona Karahoda, Sara Karbanova, Lucie Jiraskova, Susan L. Greenwood, Jocelyn D. Glazier and Frantisek Staud
      Drug Metabolism and Disposition November 2018, 46 (11) 1817-1826; DOI: https://doi.org/10.1124/dmd.118.083329
  13. Steppan, Claire M.

    1. You have access
      Human Pluripotent Stem Cell–Derived Kidney Model for Nephrotoxicity Studies
      Piyush Bajaj, A. David Rodrigues, Claire M. Steppan, Sandra J. Engle, Sumathy Mathialagan and Thomas Schroeter
      Drug Metabolism and Disposition November 2018, 46 (11) 1703-1711; DOI: https://doi.org/10.1124/dmd.118.082727

T

  1. Takahashi, Koji

    1. You have access
      Application of Intestinal Epithelial Cells Differentiated from Human Induced Pluripotent Stem Cells for Studies of Prodrug Hydrolysis and Drug Absorption in the Small Intestine
      Takanori Akazawa, Shinpei Yoshida, Shuichi Ohnishi, Takushi Kanazu, Makoto Kawai and Koji Takahashi
      Drug Metabolism and Disposition November 2018, 46 (11) 1497-1506; DOI: https://doi.org/10.1124/dmd.118.083246
  2. Takehara, Shoko

    1. You have access
      Characterization of P-Glycoprotein Humanized Mice Generated by Chromosome Engineering Technology: Its Utility for Prediction of Drug Distribution to the Brain in Humans
      Yuki Yamasaki, Kaoru Kobayashi, Fuka Okuya, Naoyo Kajitani, Kanako Kazuki, Satoshi Abe, Shoko Takehara, Shingo Ito, Seiryo Ogata, Tatsuki Uemura, Sumio Ohtsuki, Genki Minegishi, Hidetaka Akita, Kan Chiba, Mitsuo Oshimura and Yasuhiro Kazuki
      Drug Metabolism and Disposition November 2018, 46 (11) 1756-1766; DOI: https://doi.org/10.1124/dmd.118.081216
  3. Takezawa, Toshiaki

    1. Open Access
      Fabrication of a Corneal Model Composed of Corneal Epithelial and Endothelial Cells via a Collagen Vitrigel Membrane Functioned as an Acellular Stroma and Its Application to the Corneal Permeability Test of Chemicals
      Hiroyuki Yamaguchi and Toshiaki Takezawa
      Drug Metabolism and Disposition November 2018, 46 (11) 1684-1691; DOI: https://doi.org/10.1124/dmd.118.080820
  4. Tang, Huadong

    1. You have access
      Porcine Prediction of Pharmacokinetic Parameters in People: A Pig in a Poke?
      Huadong Tang and Michael Mayersohn
      Drug Metabolism and Disposition November 2018, 46 (11) 1712-1724; DOI: https://doi.org/10.1124/dmd.118.083311
  5. Templin, Markus F.

    1. You have access
      Mouse Hepatomas with Ha-ras and B-raf Mutations Differ in Mitogen-Activated Protein Kinase Signaling and Response to Constitutive Androstane Receptor Activation
      Albert Braeuning, Ferdinand Kollotzek, Eva Zeller, Thomas Knorpp, Markus F. Templin and Michael Schwarz
      Drug Metabolism and Disposition November 2018, 46 (11) 1462-1465; DOI: https://doi.org/10.1124/dmd.118.083014
  6. Terasaki, Tetsuya

    1. You have access
      Evaluation of Organic Anion Transporter 1A2-knock-in Mice as a Model of Human Blood-brain Barrier
      Yamato Sano, Tadahaya Mizuno, Tatsuki Mochizuki, Yasuo Uchida, Mina Umetsu, Tetsuya Terasaki and Hiroyuki Kusuhara
      Drug Metabolism and Disposition November 2018, 46 (11) 1767-1775; DOI: https://doi.org/10.1124/dmd.118.081877
  7. Toth, Erica L.

    1. You have access
      Gene-by-Environment Interaction of Bcrp−/− and Methionine- and Choline-Deficient Diet–Induced Nonalcoholic Steatohepatitis Alters SN-38 Disposition
      Erica L. Toth, Hui Li, Anika L. Dzierlenga, John D. Clarke, Anna Vildhede, Michael Goedken and Nathan J. Cherrington
      Drug Metabolism and Disposition November 2018, 46 (11) 1478-1486; DOI: https://doi.org/10.1124/dmd.118.082081
  8. Tsamandouras, Nikolaos

    1. You have access
      Physiologically Relevant, Humanized Intestinal Systems to Study Metabolism and Transport of Small Molecule Therapeutics
      Aarti Sawant-Basak, A. David Rodrigues, Matthew Lech, Regis Doyonnas, Marion Kasaian, Bhagwat Prasad and Nikolaos Tsamandouras
      Drug Metabolism and Disposition November 2018, 46 (11) 1581-1587; DOI: https://doi.org/10.1124/dmd.118.082784
  9. Tukey, Robert H.

    1. You have access
      Humanized UGT1 Mice, Regulation of UGT1A1, and the Role of the Intestinal Tract in Neonatal Hyperbilirubinemia and Breast Milk-Induced Jaundice
      Shujuan Chen and Robert H. Tukey
      Drug Metabolism and Disposition November 2018, 46 (11) 1745-1755; DOI: https://doi.org/10.1124/dmd.118.083212
  10. Turnbaugh, Peter J.

    1. You have access
      How to Determine the Role of the Microbiome in Drug Disposition
      Jordan E. Bisanz, Peter Spanogiannopoulos, Lindsey M. Pieper, Annamarie E. Bustion and Peter J. Turnbaugh
      Drug Metabolism and Disposition November 2018, 46 (11) 1588-1595; DOI: https://doi.org/10.1124/dmd.118.083402

U

  1. Uchida, Yasuo

    1. You have access
      Evaluation of Organic Anion Transporter 1A2-knock-in Mice as a Model of Human Blood-brain Barrier
      Yamato Sano, Tadahaya Mizuno, Tatsuki Mochizuki, Yasuo Uchida, Mina Umetsu, Tetsuya Terasaki and Hiroyuki Kusuhara
      Drug Metabolism and Disposition November 2018, 46 (11) 1767-1775; DOI: https://doi.org/10.1124/dmd.118.081877
  2. Uemura, Tatsuki

    1. You have access
      Characterization of P-Glycoprotein Humanized Mice Generated by Chromosome Engineering Technology: Its Utility for Prediction of Drug Distribution to the Brain in Humans
      Yuki Yamasaki, Kaoru Kobayashi, Fuka Okuya, Naoyo Kajitani, Kanako Kazuki, Satoshi Abe, Shoko Takehara, Shingo Ito, Seiryo Ogata, Tatsuki Uemura, Sumio Ohtsuki, Genki Minegishi, Hidetaka Akita, Kan Chiba, Mitsuo Oshimura and Yasuhiro Kazuki
      Drug Metabolism and Disposition November 2018, 46 (11) 1756-1766; DOI: https://doi.org/10.1124/dmd.118.081216
  3. Uetrecht, Jack

    1. Do In Vitro Assays Predict Drug Candidate Idiosyncratic Drug-Induced Liver Injury Risk?
      Open Access
      Do In Vitro Assays Predict Drug Candidate Idiosyncratic Drug-Induced Liver Injury Risk?
      J. Gerry Kenna and Jack Uetrecht
      Drug Metabolism and Disposition November 2018, 46 (11) 1658-1669; DOI: https://doi.org/10.1124/dmd.118.082719
  4. Umetsu, Mina

    1. You have access
      Evaluation of Organic Anion Transporter 1A2-knock-in Mice as a Model of Human Blood-brain Barrier
      Yamato Sano, Tadahaya Mizuno, Tatsuki Mochizuki, Yasuo Uchida, Mina Umetsu, Tetsuya Terasaki and Hiroyuki Kusuhara
      Drug Metabolism and Disposition November 2018, 46 (11) 1767-1775; DOI: https://doi.org/10.1124/dmd.118.081877
  5. Unadkat, Jashvant D.

    1. You have access
      When Does the Rate-Determining Step in the Hepatic Clearance of a Drug Switch from Sinusoidal Uptake to All Hepatobiliary Clearances? Implications for Predicting Drug-Drug Interactions
      Gabriela I. Patilea-Vrana and Jashvant D. Unadkat
      Drug Metabolism and Disposition November 2018, 46 (11) 1487-1496; DOI: https://doi.org/10.1124/dmd.118.081307
  6. Underhill, Gregory H.

    1. You have access
      Advances in Engineered Human Liver Platforms for Drug Metabolism Studies
      Gregory H. Underhill and Salman R. Khetani
      Drug Metabolism and Disposition November 2018, 46 (11) 1626-1637; DOI: https://doi.org/10.1124/dmd.118.083295

V

  1. Vaes, W. H. J.

    1. You have access
      An Ex Vivo Fermentation Screening Platform to Study Drug Metabolism by Human Gut Microbiota
      E. van de Steeg, F. H. J. Schuren, R. Scott Obach, C. van Woudenbergh, Gregory S. Walker, M. Heerikhuisen, I. H. G. Nooijen and W. H. J. Vaes
      Drug Metabolism and Disposition November 2018, 46 (11) 1596-1607; DOI: https://doi.org/10.1124/dmd.118.081026
  2. van de Steeg, E.

    1. You have access
      An Ex Vivo Fermentation Screening Platform to Study Drug Metabolism by Human Gut Microbiota
      E. van de Steeg, F. H. J. Schuren, R. Scott Obach, C. van Woudenbergh, Gregory S. Walker, M. Heerikhuisen, I. H. G. Nooijen and W. H. J. Vaes
      Drug Metabolism and Disposition November 2018, 46 (11) 1596-1607; DOI: https://doi.org/10.1124/dmd.118.081026
  3. Vanhove, Thomas

    1. You have access
      Relationship between In Vivo CYP3A4 Activity, CYP3A5 Genotype, and Systemic Tacrolimus Metabolite/Parent Drug Ratio in Renal Transplant Recipients and Healthy Volunteers
      Thomas Vanhove, Hylke de Jonge, Henriëtte de Loor, Marlies Oorts, Jan de Hoon, Anton Pohanka, Pieter Annaert and Dirk R. J. Kuypers
      Drug Metabolism and Disposition November 2018, 46 (11) 1507-1513; DOI: https://doi.org/10.1124/dmd.118.081935
  4. van Woudenbergh, C.

    1. You have access
      An Ex Vivo Fermentation Screening Platform to Study Drug Metabolism by Human Gut Microbiota
      E. van de Steeg, F. H. J. Schuren, R. Scott Obach, C. van Woudenbergh, Gregory S. Walker, M. Heerikhuisen, I. H. G. Nooijen and W. H. J. Vaes
      Drug Metabolism and Disposition November 2018, 46 (11) 1596-1607; DOI: https://doi.org/10.1124/dmd.118.081026
  5. Vildhede, Anna

    1. You have access
      Gene-by-Environment Interaction of Bcrp−/− and Methionine- and Choline-Deficient Diet–Induced Nonalcoholic Steatohepatitis Alters SN-38 Disposition
      Erica L. Toth, Hui Li, Anika L. Dzierlenga, John D. Clarke, Anna Vildhede, Michael Goedken and Nathan J. Cherrington
      Drug Metabolism and Disposition November 2018, 46 (11) 1478-1486; DOI: https://doi.org/10.1124/dmd.118.082081

W

  1. Walker, Gregory S.

    1. You have access
      An Ex Vivo Fermentation Screening Platform to Study Drug Metabolism by Human Gut Microbiota
      E. van de Steeg, F. H. J. Schuren, R. Scott Obach, C. van Woudenbergh, Gregory S. Walker, M. Heerikhuisen, I. H. G. Nooijen and W. H. J. Vaes
      Drug Metabolism and Disposition November 2018, 46 (11) 1596-1607; DOI: https://doi.org/10.1124/dmd.118.081026
  2. Walles, Markus

    1. You have access
      Models and Approaches Describing the Metabolism, Transport, and Toxicity of Drugs Administered by the Ocular Route
      Jennifer L. Dumouchel, Nagendra Chemuturi, Mark N. Milton, Gian Camenisch, James Chastain, Markus Walles, Vito Sasseville, Mithat Gunduz, Ganesh R. Iyer and Upendra A. Argikar
      Drug Metabolism and Disposition November 2018, 46 (11) 1670-1683; DOI: https://doi.org/10.1124/dmd.118.082974
  3. Wojnowski, Leszek

    1. You have access
      Health-Relevant Phenotypes in the Offspring of Mice Given CAR Activators Prior to Pregnancy
      Karin Dietrich, Jan Baumgart, Leonid Eshkind, Lea Reuter, Ute Gödtel-Armbrust, Elke Butt, Michael Musheev, Federico Marini, Piyush More, Tanja Grosser, Christof Niehrs, Leszek Wojnowski and Marianne Mathäs
      Drug Metabolism and Disposition November 2018, 46 (11) 1827-1835; DOI: https://doi.org/10.1124/dmd.118.082925
  4. Wu, Baojian

    1. You have access
      Circadian Regulation of Hepatic Cytochrome P450 2a5 by Peroxisome Proliferator-Activated Receptor γ
      Jiangming Deng, Lianxia Guo and Baojian Wu
      Drug Metabolism and Disposition November 2018, 46 (11) 1538-1545; DOI: https://doi.org/10.1124/dmd.118.083071

X

  1. Xiao, Guangqing

    1. You have access
      Emerging Kidney Models to Investigate Metabolism, Transport, and Toxicity of Drugs and Xenobiotics
      Piyush Bajaj, Swapan K. Chowdhury, Robert Yucha, Edward J. Kelly and Guangqing Xiao
      Drug Metabolism and Disposition November 2018, 46 (11) 1692-1702; DOI: https://doi.org/10.1124/dmd.118.082958

Y

  1. Yamaguchi, Hiroyuki

    1. Open Access
      Fabrication of a Corneal Model Composed of Corneal Epithelial and Endothelial Cells via a Collagen Vitrigel Membrane Functioned as an Acellular Stroma and Its Application to the Corneal Permeability Test of Chemicals
      Hiroyuki Yamaguchi and Toshiaki Takezawa
      Drug Metabolism and Disposition November 2018, 46 (11) 1684-1691; DOI: https://doi.org/10.1124/dmd.118.080820
  2. Yamasaki, Yuki

    1. You have access
      Characterization of P-Glycoprotein Humanized Mice Generated by Chromosome Engineering Technology: Its Utility for Prediction of Drug Distribution to the Brain in Humans
      Yuki Yamasaki, Kaoru Kobayashi, Fuka Okuya, Naoyo Kajitani, Kanako Kazuki, Satoshi Abe, Shoko Takehara, Shingo Ito, Seiryo Ogata, Tatsuki Uemura, Sumio Ohtsuki, Genki Minegishi, Hidetaka Akita, Kan Chiba, Mitsuo Oshimura and Yasuhiro Kazuki
      Drug Metabolism and Disposition November 2018, 46 (11) 1756-1766; DOI: https://doi.org/10.1124/dmd.118.081216
  3. Yamashita, Misaki

    1. You have access
      Generation of Intestinal Organoids Suitable for Pharmacokinetic Studies from Human Induced Pluripotent Stem Cells
      Daichi Onozato, Misaki Yamashita, Anna Nakanishi, Takumi Akagawa, Yuriko Kida, Isamu Ogawa, Tadahiro Hashita, Takahiro Iwao and Tamihide Matsunaga
      Drug Metabolism and Disposition November 2018, 46 (11) 1572-1580; DOI: https://doi.org/10.1124/dmd.118.080374
  4. Yang, Qian

    1. You have access
      Cryopreserved Human Intestinal Mucosal Epithelium: A Novel In Vitro Experimental System for the Evaluation of Enteric Drug Metabolism, Cytochrome P450 Induction, and Enterotoxicity
      Albert P. Li, Novera Alam, Kirsten Amaral, Ming-Chih David Ho, Carol Loretz, Walter Mitchell and Qian Yang
      Drug Metabolism and Disposition November 2018, 46 (11) 1562-1571; DOI: https://doi.org/10.1124/dmd.118.082875
  5. Yasuda, Kazuto

    1. Pheophorbide A: Fluorescent Bcrp Substrate to Measure Oral Drug-Drug Interactions in Real-Time In Vivo
      You have access
      Pheophorbide A: Fluorescent Bcrp Substrate to Measure Oral Drug-Drug Interactions in Real-Time In Vivo
      Kazuto Yasuda, Samit Ganguly and Erin G. Schuetz
      Drug Metabolism and Disposition November 2018, 46 (11) 1725-1733; DOI: https://doi.org/10.1124/dmd.118.083584
  6. Yoshida, Kenta

    1. You have access
      Accurate Estimation of In Vivo Inhibition Constants of Inhibitors and Fraction Metabolized of Substrates with Physiologically Based Pharmacokinetic Drug–Drug Interaction Models Incorporating Parent Drugs and Metabolites of Substrates with Cluster Newton Method
      Kenta Yoshida, Kazuya Maeda, Akihiko Konagaya and Hiroyuki Kusuhara
      Drug Metabolism and Disposition November 2018, 46 (11) 1805-1816; DOI: https://doi.org/10.1124/dmd.118.081828
  7. Yoshida, Shinpei

    1. You have access
      Application of Intestinal Epithelial Cells Differentiated from Human Induced Pluripotent Stem Cells for Studies of Prodrug Hydrolysis and Drug Absorption in the Small Intestine
      Takanori Akazawa, Shinpei Yoshida, Shuichi Ohnishi, Takushi Kanazu, Makoto Kawai and Koji Takahashi
      Drug Metabolism and Disposition November 2018, 46 (11) 1497-1506; DOI: https://doi.org/10.1124/dmd.118.083246
  8. Yucha, Robert

    1. You have access
      Emerging Kidney Models to Investigate Metabolism, Transport, and Toxicity of Drugs and Xenobiotics
      Piyush Bajaj, Swapan K. Chowdhury, Robert Yucha, Edward J. Kelly and Guangqing Xiao
      Drug Metabolism and Disposition November 2018, 46 (11) 1692-1702; DOI: https://doi.org/10.1124/dmd.118.082958

Z

  1. Zeller, Eva

    1. You have access
      Mouse Hepatomas with Ha-ras and B-raf Mutations Differ in Mitogen-Activated Protein Kinase Signaling and Response to Constitutive Androstane Receptor Activation
      Albert Braeuning, Ferdinand Kollotzek, Eva Zeller, Thomas Knorpp, Markus F. Templin and Michael Schwarz
      Drug Metabolism and Disposition November 2018, 46 (11) 1462-1465; DOI: https://doi.org/10.1124/dmd.118.083014
  2. Zhang, Qing-Yu

    1. You have access
      P450-Humanized and Human Liver Chimeric Mouse Models for Studying Xenobiotic Metabolism and Toxicity
      Karl-Dimiter Bissig, Weiguo Han, Mercedes Barzi, Nataliia Kovalchuk, Liang Ding, Xiaoyu Fan, Francis P. Pankowicz, Qing-Yu Zhang and Xinxin Ding
      Drug Metabolism and Disposition November 2018, 46 (11) 1734-1744; DOI: https://doi.org/10.1124/dmd.118.083303
  3. Zhu, Xiaochun

    1. You have access
      Assessment of the Biotransformation of Low-Turnover Drugs in the HµREL Human Hepatocyte Coculture Model
      Richard D. Burton, Todd Hieronymus, Taysir Chamem, David Heim, Shelby Anderson, Xiaochun Zhu and J. Matthew Hutzler
      Drug Metabolism and Disposition November 2018, 46 (11) 1617-1625; DOI: https://doi.org/10.1124/dmd.118.082867
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Drug Metabolism and Disposition: 46 (11)
Drug Metabolism and Disposition
Vol. 46, Issue 11
1 Nov 2018
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  • Pharmacokinetics and Disposition of Biologics
  • Physiology of the Neonatal Gastrointestinal System
  • Selective Inhibition of Human CYP2E1 by Clomethiazole
  • Tissue Drug Concentrations: Beyond the Free Drug Hypothesis
  • Liver Zonation Index of Transporters and Enzymes in Mice
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