Research ArticleSpecial Section – New Models in Drug Metabolism and Transport
Models and Approaches Describing the Metabolism, Transport, and Toxicity of Drugs Administered by the Ocular Route
Jennifer L. Dumouchel, Nagendra Chemuturi, Mark N. Milton, Gian Camenisch, James Chastain, Markus Walles, Vito Sasseville, Mithat Gunduz, Ganesh R. Iyer and Upendra A. Argikar
Drug Metabolism and Disposition November 2018, 46 (11) 1670-1683; DOI: https://doi.org/10.1124/dmd.118.082974
Jennifer L. Dumouchel
Pharmacokinetic Sciences (J.L.D., N.C., M.N.M., J.C., M.G., G.R.I., U.A.A.) and Preclinical Safety (V.S.), Novartis Institutes for BioMedical Research, Cambridge, Massachusetts; and Novartis Institutes for BioMedical Research, Basel, Switzerland (G.C., M.W.)
Nagendra Chemuturi
Pharmacokinetic Sciences (J.L.D., N.C., M.N.M., J.C., M.G., G.R.I., U.A.A.) and Preclinical Safety (V.S.), Novartis Institutes for BioMedical Research, Cambridge, Massachusetts; and Novartis Institutes for BioMedical Research, Basel, Switzerland (G.C., M.W.)
Mark N. Milton
Pharmacokinetic Sciences (J.L.D., N.C., M.N.M., J.C., M.G., G.R.I., U.A.A.) and Preclinical Safety (V.S.), Novartis Institutes for BioMedical Research, Cambridge, Massachusetts; and Novartis Institutes for BioMedical Research, Basel, Switzerland (G.C., M.W.)
Gian Camenisch
Pharmacokinetic Sciences (J.L.D., N.C., M.N.M., J.C., M.G., G.R.I., U.A.A.) and Preclinical Safety (V.S.), Novartis Institutes for BioMedical Research, Cambridge, Massachusetts; and Novartis Institutes for BioMedical Research, Basel, Switzerland (G.C., M.W.)
James Chastain
Pharmacokinetic Sciences (J.L.D., N.C., M.N.M., J.C., M.G., G.R.I., U.A.A.) and Preclinical Safety (V.S.), Novartis Institutes for BioMedical Research, Cambridge, Massachusetts; and Novartis Institutes for BioMedical Research, Basel, Switzerland (G.C., M.W.)
Markus Walles
Pharmacokinetic Sciences (J.L.D., N.C., M.N.M., J.C., M.G., G.R.I., U.A.A.) and Preclinical Safety (V.S.), Novartis Institutes for BioMedical Research, Cambridge, Massachusetts; and Novartis Institutes for BioMedical Research, Basel, Switzerland (G.C., M.W.)
Vito Sasseville
Pharmacokinetic Sciences (J.L.D., N.C., M.N.M., J.C., M.G., G.R.I., U.A.A.) and Preclinical Safety (V.S.), Novartis Institutes for BioMedical Research, Cambridge, Massachusetts; and Novartis Institutes for BioMedical Research, Basel, Switzerland (G.C., M.W.)
Mithat Gunduz
Pharmacokinetic Sciences (J.L.D., N.C., M.N.M., J.C., M.G., G.R.I., U.A.A.) and Preclinical Safety (V.S.), Novartis Institutes for BioMedical Research, Cambridge, Massachusetts; and Novartis Institutes for BioMedical Research, Basel, Switzerland (G.C., M.W.)
Ganesh R. Iyer
Pharmacokinetic Sciences (J.L.D., N.C., M.N.M., J.C., M.G., G.R.I., U.A.A.) and Preclinical Safety (V.S.), Novartis Institutes for BioMedical Research, Cambridge, Massachusetts; and Novartis Institutes for BioMedical Research, Basel, Switzerland (G.C., M.W.)
Upendra A. Argikar
Pharmacokinetic Sciences (J.L.D., N.C., M.N.M., J.C., M.G., G.R.I., U.A.A.) and Preclinical Safety (V.S.), Novartis Institutes for BioMedical Research, Cambridge, Massachusetts; and Novartis Institutes for BioMedical Research, Basel, Switzerland (G.C., M.W.)
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In this issue
Research ArticleSpecial Section – New Models in Drug Metabolism and Transport
Models of Ocular Drug Disposition and Toxicity
Jennifer L. Dumouchel, Nagendra Chemuturi, Mark N. Milton, Gian Camenisch, James Chastain, Markus Walles, Vito Sasseville, Mithat Gunduz, Ganesh R. Iyer and Upendra A. Argikar
Drug Metabolism and Disposition November 1, 2018, 46 (11) 1670-1683; DOI: https://doi.org/10.1124/dmd.118.082974
Research ArticleSpecial Section – New Models in Drug Metabolism and Transport
Models of Ocular Drug Disposition and Toxicity
Jennifer L. Dumouchel, Nagendra Chemuturi, Mark N. Milton, Gian Camenisch, James Chastain, Markus Walles, Vito Sasseville, Mithat Gunduz, Ganesh R. Iyer and Upendra A. Argikar
Drug Metabolism and Disposition November 1, 2018, 46 (11) 1670-1683; DOI: https://doi.org/10.1124/dmd.118.082974
Jump to section
- Article
- Abstract
- Introduction
- Challenges Associated with Investigating Ocular Drug Delivery and Disposition
- In Vitro Models of Ocular Transport
- In Vitro Models of Ocular Metabolism
- Ocular Toxicology
- Approaches to Human Relevant Ocular ADME Studies
- Advanced Technologies for Studying Ocular PK and Drug Distribution
- Ocular Classification System
- Summary
- Acknowledgments
- Authorship Contributions
- Footnotes
- Abbreviations
- References
- Figures & Data
- Info & Metrics
- eLetters
- PDF + SI
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