P450-Humanized and Human Liver Chimeric Mouse Models for Studying Xenobiotic Metabolism and Toxicity

Karl-Dimiter Bissig; Weiguo Han; Mercedes Barzi; Nataliia Kovalchuk; Liang Ding; Xiaoyu Fan; Francis P. Pankowicz; Qing-Yu Zhang; Xinxin Ding

doi:10.1124/dmd.118.083303

Research ArticleSpecial Section – New Models in Drug Metabolism and Transport

P450-Humanized and Human Liver Chimeric Mouse Models for Studying Xenobiotic Metabolism and Toxicity

Karl-Dimiter Bissig, Weiguo Han, Mercedes Barzi, Nataliia Kovalchuk, Liang Ding, Xiaoyu Fan, Francis P. Pankowicz, Qing-Yu Zhang and Xinxin Ding

Drug Metabolism and Disposition November 2018, 46 (11) 1734-1744; DOI: https://doi.org/10.1124/dmd.118.083303

Karl-Dimiter Bissig

Baylor College of Medicine, Houston, Texas (K.-D.B., M.B., F.P.P.); and Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona (W.H., N.K., L.D., X.F., Q.-Y.Z., X.D.)

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Weiguo Han

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Mercedes Barzi

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Nataliia Kovalchuk

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Liang Ding

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Xiaoyu Fan

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Francis P. Pankowicz

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Qing-Yu Zhang

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Xinxin Ding

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Article Information

vol. 46 no. 11 1734-1744

DOI

https://doi.org/10.1124/dmd.118.083303

PubMed

30093418

Published By

American Society for Pharmacology and Experimental Therapeutics

Print ISSN

0090-9556

Online ISSN

1521-009X

History

Received June 25, 2018
Accepted August 3, 2018
Published online October 17, 2018.

Article Versions

Earlier version (August 9, 2018 - 08:46).
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Author Information

Karl-Dimiter Bissig,
Weiguo Han,
Mercedes Barzi,
Nataliia Kovalchuk,
Liang Ding,
Xiaoyu Fan,
Francis P. Pankowicz,
Qing-Yu Zhang, and
Xinxin Ding

Baylor College of Medicine, Houston, Texas (K.-D.B., M.B., F.P.P.); and Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona (W.H., N.K., L.D., X.F., Q.-Y.Z., X.D.)

Address correspondence to:
Dr. Xinxin Ding, Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ 85721. E-mail: xding{at}pharmacy.arizona.edu; or Karl-Dimiter Bissig, Baylor College of Medicine, Houston, TX 77030. E-mail: bissig{at}bcm.edu

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Drug Metabolism and Disposition

Vol. 46, Issue 11

1 Nov 2018

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Research ArticleSpecial Section – New Models in Drug Metabolism and Transport