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Research ArticleSpecial Section – New Models in Drug Metabolism and Transport

P450-Humanized and Human Liver Chimeric Mouse Models for Studying Xenobiotic Metabolism and Toxicity

Karl-Dimiter Bissig, Weiguo Han, Mercedes Barzi, Nataliia Kovalchuk, Liang Ding, Xiaoyu Fan, Francis P. Pankowicz, Qing-Yu Zhang and Xinxin Ding
Drug Metabolism and Disposition November 2018, 46 (11) 1734-1744; DOI: https://doi.org/10.1124/dmd.118.083303
Karl-Dimiter Bissig
Baylor College of Medicine, Houston, Texas (K.-D.B., M.B., F.P.P.); and Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona (W.H., N.K., L.D., X.F., Q.-Y.Z., X.D.)
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Weiguo Han
Baylor College of Medicine, Houston, Texas (K.-D.B., M.B., F.P.P.); and Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona (W.H., N.K., L.D., X.F., Q.-Y.Z., X.D.)
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Mercedes Barzi
Baylor College of Medicine, Houston, Texas (K.-D.B., M.B., F.P.P.); and Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona (W.H., N.K., L.D., X.F., Q.-Y.Z., X.D.)
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Nataliia Kovalchuk
Baylor College of Medicine, Houston, Texas (K.-D.B., M.B., F.P.P.); and Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona (W.H., N.K., L.D., X.F., Q.-Y.Z., X.D.)
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Liang Ding
Baylor College of Medicine, Houston, Texas (K.-D.B., M.B., F.P.P.); and Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona (W.H., N.K., L.D., X.F., Q.-Y.Z., X.D.)
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Xiaoyu Fan
Baylor College of Medicine, Houston, Texas (K.-D.B., M.B., F.P.P.); and Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona (W.H., N.K., L.D., X.F., Q.-Y.Z., X.D.)
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Francis P. Pankowicz
Baylor College of Medicine, Houston, Texas (K.-D.B., M.B., F.P.P.); and Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona (W.H., N.K., L.D., X.F., Q.-Y.Z., X.D.)
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Qing-Yu Zhang
Baylor College of Medicine, Houston, Texas (K.-D.B., M.B., F.P.P.); and Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona (W.H., N.K., L.D., X.F., Q.-Y.Z., X.D.)
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Xinxin Ding
Baylor College of Medicine, Houston, Texas (K.-D.B., M.B., F.P.P.); and Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona (W.H., N.K., L.D., X.F., Q.-Y.Z., X.D.)
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Article Information

vol. 46 no. 11 1734-1744
DOI 
https://doi.org/10.1124/dmd.118.083303
PubMed 
30093418

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received June 25, 2018
  • Accepted August 3, 2018
  • Published online October 17, 2018.

Article Versions

  • Earlier version (August 9, 2018 - 08:46).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2018 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Karl-Dimiter Bissig,
  2. Weiguo Han,
  3. Mercedes Barzi,
  4. Nataliia Kovalchuk,
  5. Liang Ding,
  6. Xiaoyu Fan,
  7. Francis P. Pankowicz,
  8. Qing-Yu Zhang, and
  9. Xinxin Ding
  1. Baylor College of Medicine, Houston, Texas (K.-D.B., M.B., F.P.P.); and Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona (W.H., N.K., L.D., X.F., Q.-Y.Z., X.D.)
  1. Address correspondence to:
    Dr. Xinxin Ding, Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ 85721. E-mail: xding{at}pharmacy.arizona.edu; or Karl-Dimiter Bissig, Baylor College of Medicine, Houston, TX 77030. E-mail: bissig{at}bcm.edu
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Sep 2018381067
Oct 201819015783
Nov 20181210663
Dec 201876349
Jan 2019392931
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Drug Metabolism and Disposition: 46 (11)
Drug Metabolism and Disposition
Vol. 46, Issue 11
1 Nov 2018
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Research ArticleSpecial Section – New Models in Drug Metabolism and Transport

Humanized Mouse Models

Karl-Dimiter Bissig, Weiguo Han, Mercedes Barzi, Nataliia Kovalchuk, Liang Ding, Xiaoyu Fan, Francis P. Pankowicz, Qing-Yu Zhang and Xinxin Ding
Drug Metabolism and Disposition November 1, 2018, 46 (11) 1734-1744; DOI: https://doi.org/10.1124/dmd.118.083303

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Research ArticleSpecial Section – New Models in Drug Metabolism and Transport

Humanized Mouse Models

Karl-Dimiter Bissig, Weiguo Han, Mercedes Barzi, Nataliia Kovalchuk, Liang Ding, Xiaoyu Fan, Francis P. Pankowicz, Qing-Yu Zhang and Xinxin Ding
Drug Metabolism and Disposition November 1, 2018, 46 (11) 1734-1744; DOI: https://doi.org/10.1124/dmd.118.083303
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