Index by author
April 01, 2018; Volume 46,Issue 4
A
Artursson, Per
- Open AccessDirect Quantification of Cytochromes P450 and Drug Transporters—A Rapid, Targeted Mass Spectrometry-Based Immunoassay Panel for Tissues and Cell Culture LysatesFrederik Weiß, Helen S. Hammer, Kathrin Klein, Hannes Planatscher, Ulrich M. Zanger, Agneta Norén, Christine Wegler, Per Artursson, Thomas O. Joos and Oliver PoetzDrug Metabolism and Disposition April 2018, 46 (4) 387-396; DOI: https://doi.org/10.1124/dmd.117.078626
B
Bansal, Sumit
- You have accessIdentification of Galeterone and Abiraterone as Inhibitors of Dehydroepiandrosterone Sulfonation Catalyzed by Human Hepatic Cytosol, SULT2A1, SULT2B1b, and SULT1E1Caleb Keng Yan Yip, Sumit Bansal, Siew Ying Wong and Aik Jiang LauDrug Metabolism and Disposition April 2018, 46 (4) 470-482; DOI: https://doi.org/10.1124/dmd.117.078980
Böhmert, Linda
- You have accessRegulation of Drug Metabolism by the Interplay of Inflammatory Signaling, Steatosis, and Xeno-Sensing Receptors in HepaRG CellsNorman Tanner, Lisa Kubik, Claudia Luckert, Maria Thomas, Ute Hofmann, Ulrich M. Zanger, Linda Böhmert, Alfonso Lampen and Albert BraeuningDrug Metabolism and Disposition April 2018, 46 (4) 326-335; DOI: https://doi.org/10.1124/dmd.117.078675
Braeuning, Albert
- You have accessRegulation of Drug Metabolism by the Interplay of Inflammatory Signaling, Steatosis, and Xeno-Sensing Receptors in HepaRG CellsNorman Tanner, Lisa Kubik, Claudia Luckert, Maria Thomas, Ute Hofmann, Ulrich M. Zanger, Linda Böhmert, Alfonso Lampen and Albert BraeuningDrug Metabolism and Disposition April 2018, 46 (4) 326-335; DOI: https://doi.org/10.1124/dmd.117.078675
C
Calamia, Justina
- You have accessPolymorphic Human Sulfotransferase 2A1 Mediates the Formation of 25-Hydroxyvitamin D3-3-O-Sulfate, a Major Circulating Vitamin D Metabolite in HumansTimothy Wong, Zhican Wang, Brian D. Chapron, Mizuki Suzuki, Katrina G. Claw, Chunying Gao, Robert S. Foti, Bhagwat Prasad, Alenka Chapron, Justina Calamia, Amarjit Chaudhry, Erin G. Schuetz, Ronald L. Horst, Qingcheng Mao, Ian H. de Boer, Timothy A. Thornton and Kenneth E. ThummelDrug Metabolism and Disposition April 2018, 46 (4) 367-379; DOI: https://doi.org/10.1124/dmd.117.078428
Chang, George
- You have accessComparison of Species and Cell-Type Differences in Fraction Unbound of Liver Tissues, Hepatocytes, and Cell LinesKeith Riccardi, Sangwoo Ryu, Jian Lin, Phillip Yates, David Tess, Rui Li, Dhirender Singh, Brian R. Holder, Brendon Kapinos, George Chang and Li DiDrug Metabolism and Disposition April 2018, 46 (4) 415-421; DOI: https://doi.org/10.1124/dmd.117.079152
Chapron, Alenka
- You have accessPolymorphic Human Sulfotransferase 2A1 Mediates the Formation of 25-Hydroxyvitamin D3-3-O-Sulfate, a Major Circulating Vitamin D Metabolite in HumansTimothy Wong, Zhican Wang, Brian D. Chapron, Mizuki Suzuki, Katrina G. Claw, Chunying Gao, Robert S. Foti, Bhagwat Prasad, Alenka Chapron, Justina Calamia, Amarjit Chaudhry, Erin G. Schuetz, Ronald L. Horst, Qingcheng Mao, Ian H. de Boer, Timothy A. Thornton and Kenneth E. ThummelDrug Metabolism and Disposition April 2018, 46 (4) 367-379; DOI: https://doi.org/10.1124/dmd.117.078428
Chapron, Brian D.
- You have accessPolymorphic Human Sulfotransferase 2A1 Mediates the Formation of 25-Hydroxyvitamin D3-3-O-Sulfate, a Major Circulating Vitamin D Metabolite in HumansTimothy Wong, Zhican Wang, Brian D. Chapron, Mizuki Suzuki, Katrina G. Claw, Chunying Gao, Robert S. Foti, Bhagwat Prasad, Alenka Chapron, Justina Calamia, Amarjit Chaudhry, Erin G. Schuetz, Ronald L. Horst, Qingcheng Mao, Ian H. de Boer, Timothy A. Thornton and Kenneth E. ThummelDrug Metabolism and Disposition April 2018, 46 (4) 367-379; DOI: https://doi.org/10.1124/dmd.117.078428
Chaudhry, Amarjit
- You have accessPolymorphic Human Sulfotransferase 2A1 Mediates the Formation of 25-Hydroxyvitamin D3-3-O-Sulfate, a Major Circulating Vitamin D Metabolite in HumansTimothy Wong, Zhican Wang, Brian D. Chapron, Mizuki Suzuki, Katrina G. Claw, Chunying Gao, Robert S. Foti, Bhagwat Prasad, Alenka Chapron, Justina Calamia, Amarjit Chaudhry, Erin G. Schuetz, Ronald L. Horst, Qingcheng Mao, Ian H. de Boer, Timothy A. Thornton and Kenneth E. ThummelDrug Metabolism and Disposition April 2018, 46 (4) 367-379; DOI: https://doi.org/10.1124/dmd.117.078428
Chen, Bingming
- You have accessLC-MS Differential Analysis for Fast and Sensitive Determination of Biotransformation of Therapeutic ProteinsMing Yao, Bingming Chen, Weiping Zhao, John T. Mehl, Lingjun Li and Mingshe ZhuDrug Metabolism and Disposition April 2018, 46 (4) 451-457; DOI: https://doi.org/10.1124/dmd.117.077792
Chen, Xiaohui
- You have accessIdentification of Ketene-Reactive Intermediate of Erlotinib Possibly Responsible for Inactivation of P450 EnzymesHuimin Zhao, Siyuan Li, Zixin Yang, Ying Peng, Xiaohui Chen and Jiang ZhengDrug Metabolism and Disposition April 2018, 46 (4) 442-450; DOI: https://doi.org/10.1124/dmd.117.079327
Chu, Chun
- You have accessRole of c-Jun-N-Terminal Kinase in Pregnane X Receptor-Mediated Induction of Human Cytochrome P4503A4 In VitroGuncha Taneja, Chun Chu, Paramahamsa Maturu, Bhagavatula Moorthy and Romi GhoseDrug Metabolism and Disposition April 2018, 46 (4) 397-404; DOI: https://doi.org/10.1124/dmd.117.079160
Claw, Katrina G.
- You have accessPolymorphic Human Sulfotransferase 2A1 Mediates the Formation of 25-Hydroxyvitamin D3-3-O-Sulfate, a Major Circulating Vitamin D Metabolite in HumansTimothy Wong, Zhican Wang, Brian D. Chapron, Mizuki Suzuki, Katrina G. Claw, Chunying Gao, Robert S. Foti, Bhagwat Prasad, Alenka Chapron, Justina Calamia, Amarjit Chaudhry, Erin G. Schuetz, Ronald L. Horst, Qingcheng Mao, Ian H. de Boer, Timothy A. Thornton and Kenneth E. ThummelDrug Metabolism and Disposition April 2018, 46 (4) 367-379; DOI: https://doi.org/10.1124/dmd.117.078428
D
Darwich, Adam S.
- Open AccessSimultaneous Assessment In Vitro of Transporter and Metabolic Processes in Hepatic Drug Clearance: Use of a Media Loss ApproachJames Harrison, Tom De Bruyn, Adam S. Darwich and J. Brian HoustonDrug Metabolism and Disposition April 2018, 46 (4) 405-414; DOI: https://doi.org/10.1124/dmd.117.079590
de Boer, Ian H.
- You have accessPolymorphic Human Sulfotransferase 2A1 Mediates the Formation of 25-Hydroxyvitamin D3-3-O-Sulfate, a Major Circulating Vitamin D Metabolite in HumansTimothy Wong, Zhican Wang, Brian D. Chapron, Mizuki Suzuki, Katrina G. Claw, Chunying Gao, Robert S. Foti, Bhagwat Prasad, Alenka Chapron, Justina Calamia, Amarjit Chaudhry, Erin G. Schuetz, Ronald L. Horst, Qingcheng Mao, Ian H. de Boer, Timothy A. Thornton and Kenneth E. ThummelDrug Metabolism and Disposition April 2018, 46 (4) 367-379; DOI: https://doi.org/10.1124/dmd.117.078428
De Bruyn, Tom
- Open AccessSimultaneous Assessment In Vitro of Transporter and Metabolic Processes in Hepatic Drug Clearance: Use of a Media Loss ApproachJames Harrison, Tom De Bruyn, Adam S. Darwich and J. Brian HoustonDrug Metabolism and Disposition April 2018, 46 (4) 405-414; DOI: https://doi.org/10.1124/dmd.117.079590
Di, Li
- You have accessA Study on Pharmacokinetics of Bosentan with Systems Modeling, Part 1: Translating Systemic Plasma Concentration to Liver Exposure in Healthy SubjectsRui Li, Mark Niosi, Nathaniel Johnson, David A. Tess, Emi Kimoto, Jian Lin, Xin Yang, Keith A. Riccardi, Sangwoo Ryu, Ayman F. El-Kattan, Tristan S. Maurer, Larry M. Tremaine and Li DiDrug Metabolism and Disposition April 2018, 46 (4) 346-356; DOI: https://doi.org/10.1124/dmd.117.078790
- You have accessComparison of Species and Cell-Type Differences in Fraction Unbound of Liver Tissues, Hepatocytes, and Cell LinesKeith Riccardi, Sangwoo Ryu, Jian Lin, Phillip Yates, David Tess, Rui Li, Dhirender Singh, Brian R. Holder, Brendon Kapinos, George Chang and Li DiDrug Metabolism and Disposition April 2018, 46 (4) 415-421; DOI: https://doi.org/10.1124/dmd.117.079152
- You have accessA Study on Pharmacokinetics of Bosentan with Systems Modeling, Part 2: Prospectively Predicting Systemic and Liver Exposure in Healthy SubjectsRui Li, Emi Kimoto, Mark Niosi, David A. Tess, Jian Lin, Larry M. Tremaine and Li DiDrug Metabolism and Disposition April 2018, 46 (4) 357-366; DOI: https://doi.org/10.1124/dmd.117.078808
E
El-Kattan, Ayman F.
- You have accessA Study on Pharmacokinetics of Bosentan with Systems Modeling, Part 1: Translating Systemic Plasma Concentration to Liver Exposure in Healthy SubjectsRui Li, Mark Niosi, Nathaniel Johnson, David A. Tess, Emi Kimoto, Jian Lin, Xin Yang, Keith A. Riccardi, Sangwoo Ryu, Ayman F. El-Kattan, Tristan S. Maurer, Larry M. Tremaine and Li DiDrug Metabolism and Disposition April 2018, 46 (4) 346-356; DOI: https://doi.org/10.1124/dmd.117.078790
Evangelista, Eric A.
- You have accessCYP2J2 Expression in Adult Ventricular Myocytes Protects Against Reactive Oxygen Species ToxicityEric A. Evangelista, Rozenn N. Lemaitre, Nona Sotoodehnia, Sina A. Gharib and Rheem A. TotahDrug Metabolism and Disposition April 2018, 46 (4) 380-386; DOI: https://doi.org/10.1124/dmd.117.078840
F
Fang, Yan
- You have accessMaternal-Fetal Disposition and Metabolism of Retrorsine in Pregnant RatsXia Li, Xiaojing Yang, E Xiang, Jinyuan Luo, Shuaikai Qiu, Yan Fang, Li Zhang, Yu Guo, Jiang Zheng and Hui WangDrug Metabolism and Disposition April 2018, 46 (4) 422-428; DOI: https://doi.org/10.1124/dmd.117.079186
Fischer, Volker
- You have accessMathematical and Experimental Validation of Flux Dialysis Method: An Improved Approach to Measure Unbound Fraction for Compounds with High Protein Binding and Other Challenging PropertiesJ. Cory Kalvass, Colin Phipps, Gary J. Jenkins, Patricia Stuart, Xiaomei Zhang, Lance Heinle, Marjoleen J. M. A. Nijsen and Volker FischerDrug Metabolism and Disposition April 2018, 46 (4) 458-469; DOI: https://doi.org/10.1124/dmd.117.078915
Foti, Robert S.
- You have accessPolymorphic Human Sulfotransferase 2A1 Mediates the Formation of 25-Hydroxyvitamin D3-3-O-Sulfate, a Major Circulating Vitamin D Metabolite in HumansTimothy Wong, Zhican Wang, Brian D. Chapron, Mizuki Suzuki, Katrina G. Claw, Chunying Gao, Robert S. Foti, Bhagwat Prasad, Alenka Chapron, Justina Calamia, Amarjit Chaudhry, Erin G. Schuetz, Ronald L. Horst, Qingcheng Mao, Ian H. de Boer, Timothy A. Thornton and Kenneth E. ThummelDrug Metabolism and Disposition April 2018, 46 (4) 367-379; DOI: https://doi.org/10.1124/dmd.117.078428
G
Gao, Chunying
- You have accessPolymorphic Human Sulfotransferase 2A1 Mediates the Formation of 25-Hydroxyvitamin D3-3-O-Sulfate, a Major Circulating Vitamin D Metabolite in HumansTimothy Wong, Zhican Wang, Brian D. Chapron, Mizuki Suzuki, Katrina G. Claw, Chunying Gao, Robert S. Foti, Bhagwat Prasad, Alenka Chapron, Justina Calamia, Amarjit Chaudhry, Erin G. Schuetz, Ronald L. Horst, Qingcheng Mao, Ian H. de Boer, Timothy A. Thornton and Kenneth E. ThummelDrug Metabolism and Disposition April 2018, 46 (4) 367-379; DOI: https://doi.org/10.1124/dmd.117.078428
Gao, Xiaoxia
- You have accessMetabolic Profiling of the Novel Hypoxia-Inducible Factor 2α Inhibitor PT2385 In Vivo and In VitroCen Xie, Xiaoxia Gao, Dongxue Sun, Youbo Zhang, Kristopher W. Krausz, Xuemei Qin and Frank J. GonzalezDrug Metabolism and Disposition April 2018, 46 (4) 336-345; DOI: https://doi.org/10.1124/dmd.117.079723
Gharib, Sina A.
- You have accessCYP2J2 Expression in Adult Ventricular Myocytes Protects Against Reactive Oxygen Species ToxicityEric A. Evangelista, Rozenn N. Lemaitre, Nona Sotoodehnia, Sina A. Gharib and Rheem A. TotahDrug Metabolism and Disposition April 2018, 46 (4) 380-386; DOI: https://doi.org/10.1124/dmd.117.078840
Ghose, Romi
- You have accessRole of c-Jun-N-Terminal Kinase in Pregnane X Receptor-Mediated Induction of Human Cytochrome P4503A4 In VitroGuncha Taneja, Chun Chu, Paramahamsa Maturu, Bhagavatula Moorthy and Romi GhoseDrug Metabolism and Disposition April 2018, 46 (4) 397-404; DOI: https://doi.org/10.1124/dmd.117.079160
Gonzalez, Frank J.
- You have accessMetabolic Profiling of the Novel Hypoxia-Inducible Factor 2α Inhibitor PT2385 In Vivo and In VitroCen Xie, Xiaoxia Gao, Dongxue Sun, Youbo Zhang, Kristopher W. Krausz, Xuemei Qin and Frank J. GonzalezDrug Metabolism and Disposition April 2018, 46 (4) 336-345; DOI: https://doi.org/10.1124/dmd.117.079723
Guo, Yu
- You have accessMaternal-Fetal Disposition and Metabolism of Retrorsine in Pregnant RatsXia Li, Xiaojing Yang, E Xiang, Jinyuan Luo, Shuaikai Qiu, Yan Fang, Li Zhang, Yu Guo, Jiang Zheng and Hui WangDrug Metabolism and Disposition April 2018, 46 (4) 422-428; DOI: https://doi.org/10.1124/dmd.117.079186
H
Hammer, Helen S.
- Open AccessDirect Quantification of Cytochromes P450 and Drug Transporters—A Rapid, Targeted Mass Spectrometry-Based Immunoassay Panel for Tissues and Cell Culture LysatesFrederik Weiß, Helen S. Hammer, Kathrin Klein, Hannes Planatscher, Ulrich M. Zanger, Agneta Norén, Christine Wegler, Per Artursson, Thomas O. Joos and Oliver PoetzDrug Metabolism and Disposition April 2018, 46 (4) 387-396; DOI: https://doi.org/10.1124/dmd.117.078626
Harrison, James
- Open AccessSimultaneous Assessment In Vitro of Transporter and Metabolic Processes in Hepatic Drug Clearance: Use of a Media Loss ApproachJames Harrison, Tom De Bruyn, Adam S. Darwich and J. Brian HoustonDrug Metabolism and Disposition April 2018, 46 (4) 405-414; DOI: https://doi.org/10.1124/dmd.117.079590
Heinle, Lance
- You have accessMathematical and Experimental Validation of Flux Dialysis Method: An Improved Approach to Measure Unbound Fraction for Compounds with High Protein Binding and Other Challenging PropertiesJ. Cory Kalvass, Colin Phipps, Gary J. Jenkins, Patricia Stuart, Xiaomei Zhang, Lance Heinle, Marjoleen J. M. A. Nijsen and Volker FischerDrug Metabolism and Disposition April 2018, 46 (4) 458-469; DOI: https://doi.org/10.1124/dmd.117.078915
Hofmann, Ute
- You have accessRegulation of Drug Metabolism by the Interplay of Inflammatory Signaling, Steatosis, and Xeno-Sensing Receptors in HepaRG CellsNorman Tanner, Lisa Kubik, Claudia Luckert, Maria Thomas, Ute Hofmann, Ulrich M. Zanger, Linda Böhmert, Alfonso Lampen and Albert BraeuningDrug Metabolism and Disposition April 2018, 46 (4) 326-335; DOI: https://doi.org/10.1124/dmd.117.078675
Holder, Brian R.
- You have accessComparison of Species and Cell-Type Differences in Fraction Unbound of Liver Tissues, Hepatocytes, and Cell LinesKeith Riccardi, Sangwoo Ryu, Jian Lin, Phillip Yates, David Tess, Rui Li, Dhirender Singh, Brian R. Holder, Brendon Kapinos, George Chang and Li DiDrug Metabolism and Disposition April 2018, 46 (4) 415-421; DOI: https://doi.org/10.1124/dmd.117.079152
Horst, Ronald L.
- You have accessPolymorphic Human Sulfotransferase 2A1 Mediates the Formation of 25-Hydroxyvitamin D3-3-O-Sulfate, a Major Circulating Vitamin D Metabolite in HumansTimothy Wong, Zhican Wang, Brian D. Chapron, Mizuki Suzuki, Katrina G. Claw, Chunying Gao, Robert S. Foti, Bhagwat Prasad, Alenka Chapron, Justina Calamia, Amarjit Chaudhry, Erin G. Schuetz, Ronald L. Horst, Qingcheng Mao, Ian H. de Boer, Timothy A. Thornton and Kenneth E. ThummelDrug Metabolism and Disposition April 2018, 46 (4) 367-379; DOI: https://doi.org/10.1124/dmd.117.078428
Houston, J. Brian
- Open AccessSimultaneous Assessment In Vitro of Transporter and Metabolic Processes in Hepatic Drug Clearance: Use of a Media Loss ApproachJames Harrison, Tom De Bruyn, Adam S. Darwich and J. Brian HoustonDrug Metabolism and Disposition April 2018, 46 (4) 405-414; DOI: https://doi.org/10.1124/dmd.117.079590
J
Jenkins, Gary J.
- You have accessMathematical and Experimental Validation of Flux Dialysis Method: An Improved Approach to Measure Unbound Fraction for Compounds with High Protein Binding and Other Challenging PropertiesJ. Cory Kalvass, Colin Phipps, Gary J. Jenkins, Patricia Stuart, Xiaomei Zhang, Lance Heinle, Marjoleen J. M. A. Nijsen and Volker FischerDrug Metabolism and Disposition April 2018, 46 (4) 458-469; DOI: https://doi.org/10.1124/dmd.117.078915
Johnson, Nathaniel
- You have accessA Study on Pharmacokinetics of Bosentan with Systems Modeling, Part 1: Translating Systemic Plasma Concentration to Liver Exposure in Healthy SubjectsRui Li, Mark Niosi, Nathaniel Johnson, David A. Tess, Emi Kimoto, Jian Lin, Xin Yang, Keith A. Riccardi, Sangwoo Ryu, Ayman F. El-Kattan, Tristan S. Maurer, Larry M. Tremaine and Li DiDrug Metabolism and Disposition April 2018, 46 (4) 346-356; DOI: https://doi.org/10.1124/dmd.117.078790
Joos, Thomas O.
- Open AccessDirect Quantification of Cytochromes P450 and Drug Transporters—A Rapid, Targeted Mass Spectrometry-Based Immunoassay Panel for Tissues and Cell Culture LysatesFrederik Weiß, Helen S. Hammer, Kathrin Klein, Hannes Planatscher, Ulrich M. Zanger, Agneta Norén, Christine Wegler, Per Artursson, Thomas O. Joos and Oliver PoetzDrug Metabolism and Disposition April 2018, 46 (4) 387-396; DOI: https://doi.org/10.1124/dmd.117.078626
K
Kalvass, J. Cory
- You have accessMathematical and Experimental Validation of Flux Dialysis Method: An Improved Approach to Measure Unbound Fraction for Compounds with High Protein Binding and Other Challenging PropertiesJ. Cory Kalvass, Colin Phipps, Gary J. Jenkins, Patricia Stuart, Xiaomei Zhang, Lance Heinle, Marjoleen J. M. A. Nijsen and Volker FischerDrug Metabolism and Disposition April 2018, 46 (4) 458-469; DOI: https://doi.org/10.1124/dmd.117.078915
Kapinos, Brendon
- You have accessComparison of Species and Cell-Type Differences in Fraction Unbound of Liver Tissues, Hepatocytes, and Cell LinesKeith Riccardi, Sangwoo Ryu, Jian Lin, Phillip Yates, David Tess, Rui Li, Dhirender Singh, Brian R. Holder, Brendon Kapinos, George Chang and Li DiDrug Metabolism and Disposition April 2018, 46 (4) 415-421; DOI: https://doi.org/10.1124/dmd.117.079152
Kimoto, Emi
- You have accessA Study on Pharmacokinetics of Bosentan with Systems Modeling, Part 1: Translating Systemic Plasma Concentration to Liver Exposure in Healthy SubjectsRui Li, Mark Niosi, Nathaniel Johnson, David A. Tess, Emi Kimoto, Jian Lin, Xin Yang, Keith A. Riccardi, Sangwoo Ryu, Ayman F. El-Kattan, Tristan S. Maurer, Larry M. Tremaine and Li DiDrug Metabolism and Disposition April 2018, 46 (4) 346-356; DOI: https://doi.org/10.1124/dmd.117.078790
- You have accessA Study on Pharmacokinetics of Bosentan with Systems Modeling, Part 2: Prospectively Predicting Systemic and Liver Exposure in Healthy SubjectsRui Li, Emi Kimoto, Mark Niosi, David A. Tess, Jian Lin, Larry M. Tremaine and Li DiDrug Metabolism and Disposition April 2018, 46 (4) 357-366; DOI: https://doi.org/10.1124/dmd.117.078808
Klein, Kathrin
- Open AccessDirect Quantification of Cytochromes P450 and Drug Transporters—A Rapid, Targeted Mass Spectrometry-Based Immunoassay Panel for Tissues and Cell Culture LysatesFrederik Weiß, Helen S. Hammer, Kathrin Klein, Hannes Planatscher, Ulrich M. Zanger, Agneta Norén, Christine Wegler, Per Artursson, Thomas O. Joos and Oliver PoetzDrug Metabolism and Disposition April 2018, 46 (4) 387-396; DOI: https://doi.org/10.1124/dmd.117.078626
Krausz, Kristopher W.
- You have accessMetabolic Profiling of the Novel Hypoxia-Inducible Factor 2α Inhibitor PT2385 In Vivo and In VitroCen Xie, Xiaoxia Gao, Dongxue Sun, Youbo Zhang, Kristopher W. Krausz, Xuemei Qin and Frank J. GonzalezDrug Metabolism and Disposition April 2018, 46 (4) 336-345; DOI: https://doi.org/10.1124/dmd.117.079723
Kubik, Lisa
- You have accessRegulation of Drug Metabolism by the Interplay of Inflammatory Signaling, Steatosis, and Xeno-Sensing Receptors in HepaRG CellsNorman Tanner, Lisa Kubik, Claudia Luckert, Maria Thomas, Ute Hofmann, Ulrich M. Zanger, Linda Böhmert, Alfonso Lampen and Albert BraeuningDrug Metabolism and Disposition April 2018, 46 (4) 326-335; DOI: https://doi.org/10.1124/dmd.117.078675
L
Lampen, Alfonso
- You have accessRegulation of Drug Metabolism by the Interplay of Inflammatory Signaling, Steatosis, and Xeno-Sensing Receptors in HepaRG CellsNorman Tanner, Lisa Kubik, Claudia Luckert, Maria Thomas, Ute Hofmann, Ulrich M. Zanger, Linda Böhmert, Alfonso Lampen and Albert BraeuningDrug Metabolism and Disposition April 2018, 46 (4) 326-335; DOI: https://doi.org/10.1124/dmd.117.078675
Lau, Aik Jiang
- You have accessIdentification of Galeterone and Abiraterone as Inhibitors of Dehydroepiandrosterone Sulfonation Catalyzed by Human Hepatic Cytosol, SULT2A1, SULT2B1b, and SULT1E1Caleb Keng Yan Yip, Sumit Bansal, Siew Ying Wong and Aik Jiang LauDrug Metabolism and Disposition April 2018, 46 (4) 470-482; DOI: https://doi.org/10.1124/dmd.117.078980
Lee, Anthony J.
- You have accessMetabolism and Disposition of a Novel Selective α7 Neuronal Acetylcholine Receptor Agonist ABT-126 in Humans: Characterization of the Major Roles for Flavin-Containing Monooxygenases and UDP-Glucuronosyl Transferase 1A4 and 2B10 in CatalysisHong Liu, David M. Stresser, Melissa J. Michmerhuizen, Xiaofeng Li, Ahmed A. Othman, Aimee D. Reed, Michael R. Schrimpf, Jens Sydor and Anthony J. LeeDrug Metabolism and Disposition April 2018, 46 (4) 429-439; DOI: https://doi.org/10.1124/dmd.117.077511
Lemaitre, Rozenn N.
- You have accessCYP2J2 Expression in Adult Ventricular Myocytes Protects Against Reactive Oxygen Species ToxicityEric A. Evangelista, Rozenn N. Lemaitre, Nona Sotoodehnia, Sina A. Gharib and Rheem A. TotahDrug Metabolism and Disposition April 2018, 46 (4) 380-386; DOI: https://doi.org/10.1124/dmd.117.078840
Li, Lingjun
- You have accessLC-MS Differential Analysis for Fast and Sensitive Determination of Biotransformation of Therapeutic ProteinsMing Yao, Bingming Chen, Weiping Zhao, John T. Mehl, Lingjun Li and Mingshe ZhuDrug Metabolism and Disposition April 2018, 46 (4) 451-457; DOI: https://doi.org/10.1124/dmd.117.077792
Li, Rui
- You have accessA Study on Pharmacokinetics of Bosentan with Systems Modeling, Part 1: Translating Systemic Plasma Concentration to Liver Exposure in Healthy SubjectsRui Li, Mark Niosi, Nathaniel Johnson, David A. Tess, Emi Kimoto, Jian Lin, Xin Yang, Keith A. Riccardi, Sangwoo Ryu, Ayman F. El-Kattan, Tristan S. Maurer, Larry M. Tremaine and Li DiDrug Metabolism and Disposition April 2018, 46 (4) 346-356; DOI: https://doi.org/10.1124/dmd.117.078790
- You have accessComparison of Species and Cell-Type Differences in Fraction Unbound of Liver Tissues, Hepatocytes, and Cell LinesKeith Riccardi, Sangwoo Ryu, Jian Lin, Phillip Yates, David Tess, Rui Li, Dhirender Singh, Brian R. Holder, Brendon Kapinos, George Chang and Li DiDrug Metabolism and Disposition April 2018, 46 (4) 415-421; DOI: https://doi.org/10.1124/dmd.117.079152
- You have accessA Study on Pharmacokinetics of Bosentan with Systems Modeling, Part 2: Prospectively Predicting Systemic and Liver Exposure in Healthy SubjectsRui Li, Emi Kimoto, Mark Niosi, David A. Tess, Jian Lin, Larry M. Tremaine and Li DiDrug Metabolism and Disposition April 2018, 46 (4) 357-366; DOI: https://doi.org/10.1124/dmd.117.078808
Li, Siyuan
- You have accessIdentification of Ketene-Reactive Intermediate of Erlotinib Possibly Responsible for Inactivation of P450 EnzymesHuimin Zhao, Siyuan Li, Zixin Yang, Ying Peng, Xiaohui Chen and Jiang ZhengDrug Metabolism and Disposition April 2018, 46 (4) 442-450; DOI: https://doi.org/10.1124/dmd.117.079327
Li, Xia
- You have accessMaternal-Fetal Disposition and Metabolism of Retrorsine in Pregnant RatsXia Li, Xiaojing Yang, E Xiang, Jinyuan Luo, Shuaikai Qiu, Yan Fang, Li Zhang, Yu Guo, Jiang Zheng and Hui WangDrug Metabolism and Disposition April 2018, 46 (4) 422-428; DOI: https://doi.org/10.1124/dmd.117.079186
Li, Xiaofeng
- You have accessMetabolism and Disposition of a Novel Selective α7 Neuronal Acetylcholine Receptor Agonist ABT-126 in Humans: Characterization of the Major Roles for Flavin-Containing Monooxygenases and UDP-Glucuronosyl Transferase 1A4 and 2B10 in CatalysisHong Liu, David M. Stresser, Melissa J. Michmerhuizen, Xiaofeng Li, Ahmed A. Othman, Aimee D. Reed, Michael R. Schrimpf, Jens Sydor and Anthony J. LeeDrug Metabolism and Disposition April 2018, 46 (4) 429-439; DOI: https://doi.org/10.1124/dmd.117.077511
Lin, Jian
- You have accessA Study on Pharmacokinetics of Bosentan with Systems Modeling, Part 1: Translating Systemic Plasma Concentration to Liver Exposure in Healthy SubjectsRui Li, Mark Niosi, Nathaniel Johnson, David A. Tess, Emi Kimoto, Jian Lin, Xin Yang, Keith A. Riccardi, Sangwoo Ryu, Ayman F. El-Kattan, Tristan S. Maurer, Larry M. Tremaine and Li DiDrug Metabolism and Disposition April 2018, 46 (4) 346-356; DOI: https://doi.org/10.1124/dmd.117.078790
- You have accessComparison of Species and Cell-Type Differences in Fraction Unbound of Liver Tissues, Hepatocytes, and Cell LinesKeith Riccardi, Sangwoo Ryu, Jian Lin, Phillip Yates, David Tess, Rui Li, Dhirender Singh, Brian R. Holder, Brendon Kapinos, George Chang and Li DiDrug Metabolism and Disposition April 2018, 46 (4) 415-421; DOI: https://doi.org/10.1124/dmd.117.079152
- You have accessA Study on Pharmacokinetics of Bosentan with Systems Modeling, Part 2: Prospectively Predicting Systemic and Liver Exposure in Healthy SubjectsRui Li, Emi Kimoto, Mark Niosi, David A. Tess, Jian Lin, Larry M. Tremaine and Li DiDrug Metabolism and Disposition April 2018, 46 (4) 357-366; DOI: https://doi.org/10.1124/dmd.117.078808
Liu, Hong
- You have accessMetabolism and Disposition of a Novel Selective α7 Neuronal Acetylcholine Receptor Agonist ABT-126 in Humans: Characterization of the Major Roles for Flavin-Containing Monooxygenases and UDP-Glucuronosyl Transferase 1A4 and 2B10 in CatalysisHong Liu, David M. Stresser, Melissa J. Michmerhuizen, Xiaofeng Li, Ahmed A. Othman, Aimee D. Reed, Michael R. Schrimpf, Jens Sydor and Anthony J. LeeDrug Metabolism and Disposition April 2018, 46 (4) 429-439; DOI: https://doi.org/10.1124/dmd.117.077511
Luckert, Claudia
- You have accessRegulation of Drug Metabolism by the Interplay of Inflammatory Signaling, Steatosis, and Xeno-Sensing Receptors in HepaRG CellsNorman Tanner, Lisa Kubik, Claudia Luckert, Maria Thomas, Ute Hofmann, Ulrich M. Zanger, Linda Böhmert, Alfonso Lampen and Albert BraeuningDrug Metabolism and Disposition April 2018, 46 (4) 326-335; DOI: https://doi.org/10.1124/dmd.117.078675
Luo, Jinyuan
- You have accessMaternal-Fetal Disposition and Metabolism of Retrorsine in Pregnant RatsXia Li, Xiaojing Yang, E Xiang, Jinyuan Luo, Shuaikai Qiu, Yan Fang, Li Zhang, Yu Guo, Jiang Zheng and Hui WangDrug Metabolism and Disposition April 2018, 46 (4) 422-428; DOI: https://doi.org/10.1124/dmd.117.079186
M
Mao, Qingcheng
- You have accessPolymorphic Human Sulfotransferase 2A1 Mediates the Formation of 25-Hydroxyvitamin D3-3-O-Sulfate, a Major Circulating Vitamin D Metabolite in HumansTimothy Wong, Zhican Wang, Brian D. Chapron, Mizuki Suzuki, Katrina G. Claw, Chunying Gao, Robert S. Foti, Bhagwat Prasad, Alenka Chapron, Justina Calamia, Amarjit Chaudhry, Erin G. Schuetz, Ronald L. Horst, Qingcheng Mao, Ian H. de Boer, Timothy A. Thornton and Kenneth E. ThummelDrug Metabolism and Disposition April 2018, 46 (4) 367-379; DOI: https://doi.org/10.1124/dmd.117.078428
Maturu, Paramahamsa
- You have accessRole of c-Jun-N-Terminal Kinase in Pregnane X Receptor-Mediated Induction of Human Cytochrome P4503A4 In VitroGuncha Taneja, Chun Chu, Paramahamsa Maturu, Bhagavatula Moorthy and Romi GhoseDrug Metabolism and Disposition April 2018, 46 (4) 397-404; DOI: https://doi.org/10.1124/dmd.117.079160
Maurer, Tristan S.
- You have accessA Study on Pharmacokinetics of Bosentan with Systems Modeling, Part 1: Translating Systemic Plasma Concentration to Liver Exposure in Healthy SubjectsRui Li, Mark Niosi, Nathaniel Johnson, David A. Tess, Emi Kimoto, Jian Lin, Xin Yang, Keith A. Riccardi, Sangwoo Ryu, Ayman F. El-Kattan, Tristan S. Maurer, Larry M. Tremaine and Li DiDrug Metabolism and Disposition April 2018, 46 (4) 346-356; DOI: https://doi.org/10.1124/dmd.117.078790
Mehl, John T.
- You have accessLC-MS Differential Analysis for Fast and Sensitive Determination of Biotransformation of Therapeutic ProteinsMing Yao, Bingming Chen, Weiping Zhao, John T. Mehl, Lingjun Li and Mingshe ZhuDrug Metabolism and Disposition April 2018, 46 (4) 451-457; DOI: https://doi.org/10.1124/dmd.117.077792
Michmerhuizen, Melissa J.
- You have accessMetabolism and Disposition of a Novel Selective α7 Neuronal Acetylcholine Receptor Agonist ABT-126 in Humans: Characterization of the Major Roles for Flavin-Containing Monooxygenases and UDP-Glucuronosyl Transferase 1A4 and 2B10 in CatalysisHong Liu, David M. Stresser, Melissa J. Michmerhuizen, Xiaofeng Li, Ahmed A. Othman, Aimee D. Reed, Michael R. Schrimpf, Jens Sydor and Anthony J. LeeDrug Metabolism and Disposition April 2018, 46 (4) 429-439; DOI: https://doi.org/10.1124/dmd.117.077511
Moorthy, Bhagavatula
- You have accessRole of c-Jun-N-Terminal Kinase in Pregnane X Receptor-Mediated Induction of Human Cytochrome P4503A4 In VitroGuncha Taneja, Chun Chu, Paramahamsa Maturu, Bhagavatula Moorthy and Romi GhoseDrug Metabolism and Disposition April 2018, 46 (4) 397-404; DOI: https://doi.org/10.1124/dmd.117.079160
N
Nijsen, Marjoleen J. M. A.
- You have accessMathematical and Experimental Validation of Flux Dialysis Method: An Improved Approach to Measure Unbound Fraction for Compounds with High Protein Binding and Other Challenging PropertiesJ. Cory Kalvass, Colin Phipps, Gary J. Jenkins, Patricia Stuart, Xiaomei Zhang, Lance Heinle, Marjoleen J. M. A. Nijsen and Volker FischerDrug Metabolism and Disposition April 2018, 46 (4) 458-469; DOI: https://doi.org/10.1124/dmd.117.078915
Niosi, Mark
- You have accessA Study on Pharmacokinetics of Bosentan with Systems Modeling, Part 1: Translating Systemic Plasma Concentration to Liver Exposure in Healthy SubjectsRui Li, Mark Niosi, Nathaniel Johnson, David A. Tess, Emi Kimoto, Jian Lin, Xin Yang, Keith A. Riccardi, Sangwoo Ryu, Ayman F. El-Kattan, Tristan S. Maurer, Larry M. Tremaine and Li DiDrug Metabolism and Disposition April 2018, 46 (4) 346-356; DOI: https://doi.org/10.1124/dmd.117.078790
- You have accessA Study on Pharmacokinetics of Bosentan with Systems Modeling, Part 2: Prospectively Predicting Systemic and Liver Exposure in Healthy SubjectsRui Li, Emi Kimoto, Mark Niosi, David A. Tess, Jian Lin, Larry M. Tremaine and Li DiDrug Metabolism and Disposition April 2018, 46 (4) 357-366; DOI: https://doi.org/10.1124/dmd.117.078808
Norén, Agneta
- Open AccessDirect Quantification of Cytochromes P450 and Drug Transporters—A Rapid, Targeted Mass Spectrometry-Based Immunoassay Panel for Tissues and Cell Culture LysatesFrederik Weiß, Helen S. Hammer, Kathrin Klein, Hannes Planatscher, Ulrich M. Zanger, Agneta Norén, Christine Wegler, Per Artursson, Thomas O. Joos and Oliver PoetzDrug Metabolism and Disposition April 2018, 46 (4) 387-396; DOI: https://doi.org/10.1124/dmd.117.078626
O
Othman, Ahmed A.
- You have accessMetabolism and Disposition of a Novel Selective α7 Neuronal Acetylcholine Receptor Agonist ABT-126 in Humans: Characterization of the Major Roles for Flavin-Containing Monooxygenases and UDP-Glucuronosyl Transferase 1A4 and 2B10 in CatalysisHong Liu, David M. Stresser, Melissa J. Michmerhuizen, Xiaofeng Li, Ahmed A. Othman, Aimee D. Reed, Michael R. Schrimpf, Jens Sydor and Anthony J. LeeDrug Metabolism and Disposition April 2018, 46 (4) 429-439; DOI: https://doi.org/10.1124/dmd.117.077511
P
Peng, Ying
- You have accessIdentification of Ketene-Reactive Intermediate of Erlotinib Possibly Responsible for Inactivation of P450 EnzymesHuimin Zhao, Siyuan Li, Zixin Yang, Ying Peng, Xiaohui Chen and Jiang ZhengDrug Metabolism and Disposition April 2018, 46 (4) 442-450; DOI: https://doi.org/10.1124/dmd.117.079327
Phipps, Colin
- You have accessMathematical and Experimental Validation of Flux Dialysis Method: An Improved Approach to Measure Unbound Fraction for Compounds with High Protein Binding and Other Challenging PropertiesJ. Cory Kalvass, Colin Phipps, Gary J. Jenkins, Patricia Stuart, Xiaomei Zhang, Lance Heinle, Marjoleen J. M. A. Nijsen and Volker FischerDrug Metabolism and Disposition April 2018, 46 (4) 458-469; DOI: https://doi.org/10.1124/dmd.117.078915
Planatscher, Hannes
- Open AccessDirect Quantification of Cytochromes P450 and Drug Transporters—A Rapid, Targeted Mass Spectrometry-Based Immunoassay Panel for Tissues and Cell Culture LysatesFrederik Weiß, Helen S. Hammer, Kathrin Klein, Hannes Planatscher, Ulrich M. Zanger, Agneta Norén, Christine Wegler, Per Artursson, Thomas O. Joos and Oliver PoetzDrug Metabolism and Disposition April 2018, 46 (4) 387-396; DOI: https://doi.org/10.1124/dmd.117.078626
Poetz, Oliver
- Open AccessDirect Quantification of Cytochromes P450 and Drug Transporters—A Rapid, Targeted Mass Spectrometry-Based Immunoassay Panel for Tissues and Cell Culture LysatesFrederik Weiß, Helen S. Hammer, Kathrin Klein, Hannes Planatscher, Ulrich M. Zanger, Agneta Norén, Christine Wegler, Per Artursson, Thomas O. Joos and Oliver PoetzDrug Metabolism and Disposition April 2018, 46 (4) 387-396; DOI: https://doi.org/10.1124/dmd.117.078626
Prasad, Bhagwat
- You have accessPolymorphic Human Sulfotransferase 2A1 Mediates the Formation of 25-Hydroxyvitamin D3-3-O-Sulfate, a Major Circulating Vitamin D Metabolite in HumansTimothy Wong, Zhican Wang, Brian D. Chapron, Mizuki Suzuki, Katrina G. Claw, Chunying Gao, Robert S. Foti, Bhagwat Prasad, Alenka Chapron, Justina Calamia, Amarjit Chaudhry, Erin G. Schuetz, Ronald L. Horst, Qingcheng Mao, Ian H. de Boer, Timothy A. Thornton and Kenneth E. ThummelDrug Metabolism and Disposition April 2018, 46 (4) 367-379; DOI: https://doi.org/10.1124/dmd.117.078428
Q
Qin, Xuemei
- You have accessMetabolic Profiling of the Novel Hypoxia-Inducible Factor 2α Inhibitor PT2385 In Vivo and In VitroCen Xie, Xiaoxia Gao, Dongxue Sun, Youbo Zhang, Kristopher W. Krausz, Xuemei Qin and Frank J. GonzalezDrug Metabolism and Disposition April 2018, 46 (4) 336-345; DOI: https://doi.org/10.1124/dmd.117.079723
Qiu, Shuaikai
- You have accessMaternal-Fetal Disposition and Metabolism of Retrorsine in Pregnant RatsXia Li, Xiaojing Yang, E Xiang, Jinyuan Luo, Shuaikai Qiu, Yan Fang, Li Zhang, Yu Guo, Jiang Zheng and Hui WangDrug Metabolism and Disposition April 2018, 46 (4) 422-428; DOI: https://doi.org/10.1124/dmd.117.079186
R
Reed, Aimee D.
- You have accessMetabolism and Disposition of a Novel Selective α7 Neuronal Acetylcholine Receptor Agonist ABT-126 in Humans: Characterization of the Major Roles for Flavin-Containing Monooxygenases and UDP-Glucuronosyl Transferase 1A4 and 2B10 in CatalysisHong Liu, David M. Stresser, Melissa J. Michmerhuizen, Xiaofeng Li, Ahmed A. Othman, Aimee D. Reed, Michael R. Schrimpf, Jens Sydor and Anthony J. LeeDrug Metabolism and Disposition April 2018, 46 (4) 429-439; DOI: https://doi.org/10.1124/dmd.117.077511
Riccardi, Keith
- You have accessComparison of Species and Cell-Type Differences in Fraction Unbound of Liver Tissues, Hepatocytes, and Cell LinesKeith Riccardi, Sangwoo Ryu, Jian Lin, Phillip Yates, David Tess, Rui Li, Dhirender Singh, Brian R. Holder, Brendon Kapinos, George Chang and Li DiDrug Metabolism and Disposition April 2018, 46 (4) 415-421; DOI: https://doi.org/10.1124/dmd.117.079152
Riccardi, Keith A.
- You have accessA Study on Pharmacokinetics of Bosentan with Systems Modeling, Part 1: Translating Systemic Plasma Concentration to Liver Exposure in Healthy SubjectsRui Li, Mark Niosi, Nathaniel Johnson, David A. Tess, Emi Kimoto, Jian Lin, Xin Yang, Keith A. Riccardi, Sangwoo Ryu, Ayman F. El-Kattan, Tristan S. Maurer, Larry M. Tremaine and Li DiDrug Metabolism and Disposition April 2018, 46 (4) 346-356; DOI: https://doi.org/10.1124/dmd.117.078790
Ryu, Sangwoo
- You have accessA Study on Pharmacokinetics of Bosentan with Systems Modeling, Part 1: Translating Systemic Plasma Concentration to Liver Exposure in Healthy SubjectsRui Li, Mark Niosi, Nathaniel Johnson, David A. Tess, Emi Kimoto, Jian Lin, Xin Yang, Keith A. Riccardi, Sangwoo Ryu, Ayman F. El-Kattan, Tristan S. Maurer, Larry M. Tremaine and Li DiDrug Metabolism and Disposition April 2018, 46 (4) 346-356; DOI: https://doi.org/10.1124/dmd.117.078790
- You have accessComparison of Species and Cell-Type Differences in Fraction Unbound of Liver Tissues, Hepatocytes, and Cell LinesKeith Riccardi, Sangwoo Ryu, Jian Lin, Phillip Yates, David Tess, Rui Li, Dhirender Singh, Brian R. Holder, Brendon Kapinos, George Chang and Li DiDrug Metabolism and Disposition April 2018, 46 (4) 415-421; DOI: https://doi.org/10.1124/dmd.117.079152
S
Schrimpf, Michael R.
- You have accessMetabolism and Disposition of a Novel Selective α7 Neuronal Acetylcholine Receptor Agonist ABT-126 in Humans: Characterization of the Major Roles for Flavin-Containing Monooxygenases and UDP-Glucuronosyl Transferase 1A4 and 2B10 in CatalysisHong Liu, David M. Stresser, Melissa J. Michmerhuizen, Xiaofeng Li, Ahmed A. Othman, Aimee D. Reed, Michael R. Schrimpf, Jens Sydor and Anthony J. LeeDrug Metabolism and Disposition April 2018, 46 (4) 429-439; DOI: https://doi.org/10.1124/dmd.117.077511
Schuetz, Erin G.
- You have accessPolymorphic Human Sulfotransferase 2A1 Mediates the Formation of 25-Hydroxyvitamin D3-3-O-Sulfate, a Major Circulating Vitamin D Metabolite in HumansTimothy Wong, Zhican Wang, Brian D. Chapron, Mizuki Suzuki, Katrina G. Claw, Chunying Gao, Robert S. Foti, Bhagwat Prasad, Alenka Chapron, Justina Calamia, Amarjit Chaudhry, Erin G. Schuetz, Ronald L. Horst, Qingcheng Mao, Ian H. de Boer, Timothy A. Thornton and Kenneth E. ThummelDrug Metabolism and Disposition April 2018, 46 (4) 367-379; DOI: https://doi.org/10.1124/dmd.117.078428
Singh, Dhirender
- You have accessComparison of Species and Cell-Type Differences in Fraction Unbound of Liver Tissues, Hepatocytes, and Cell LinesKeith Riccardi, Sangwoo Ryu, Jian Lin, Phillip Yates, David Tess, Rui Li, Dhirender Singh, Brian R. Holder, Brendon Kapinos, George Chang and Li DiDrug Metabolism and Disposition April 2018, 46 (4) 415-421; DOI: https://doi.org/10.1124/dmd.117.079152
Sotoodehnia, Nona
- You have accessCYP2J2 Expression in Adult Ventricular Myocytes Protects Against Reactive Oxygen Species ToxicityEric A. Evangelista, Rozenn N. Lemaitre, Nona Sotoodehnia, Sina A. Gharib and Rheem A. TotahDrug Metabolism and Disposition April 2018, 46 (4) 380-386; DOI: https://doi.org/10.1124/dmd.117.078840
Stresser, David M.
- You have accessMetabolism and Disposition of a Novel Selective α7 Neuronal Acetylcholine Receptor Agonist ABT-126 in Humans: Characterization of the Major Roles for Flavin-Containing Monooxygenases and UDP-Glucuronosyl Transferase 1A4 and 2B10 in CatalysisHong Liu, David M. Stresser, Melissa J. Michmerhuizen, Xiaofeng Li, Ahmed A. Othman, Aimee D. Reed, Michael R. Schrimpf, Jens Sydor and Anthony J. LeeDrug Metabolism and Disposition April 2018, 46 (4) 429-439; DOI: https://doi.org/10.1124/dmd.117.077511
Stuart, Patricia
- You have accessMathematical and Experimental Validation of Flux Dialysis Method: An Improved Approach to Measure Unbound Fraction for Compounds with High Protein Binding and Other Challenging PropertiesJ. Cory Kalvass, Colin Phipps, Gary J. Jenkins, Patricia Stuart, Xiaomei Zhang, Lance Heinle, Marjoleen J. M. A. Nijsen and Volker FischerDrug Metabolism and Disposition April 2018, 46 (4) 458-469; DOI: https://doi.org/10.1124/dmd.117.078915
Sun, Dongxue
- You have accessMetabolic Profiling of the Novel Hypoxia-Inducible Factor 2α Inhibitor PT2385 In Vivo and In VitroCen Xie, Xiaoxia Gao, Dongxue Sun, Youbo Zhang, Kristopher W. Krausz, Xuemei Qin and Frank J. GonzalezDrug Metabolism and Disposition April 2018, 46 (4) 336-345; DOI: https://doi.org/10.1124/dmd.117.079723
Suzuki, Mizuki
- You have accessPolymorphic Human Sulfotransferase 2A1 Mediates the Formation of 25-Hydroxyvitamin D3-3-O-Sulfate, a Major Circulating Vitamin D Metabolite in HumansTimothy Wong, Zhican Wang, Brian D. Chapron, Mizuki Suzuki, Katrina G. Claw, Chunying Gao, Robert S. Foti, Bhagwat Prasad, Alenka Chapron, Justina Calamia, Amarjit Chaudhry, Erin G. Schuetz, Ronald L. Horst, Qingcheng Mao, Ian H. de Boer, Timothy A. Thornton and Kenneth E. ThummelDrug Metabolism and Disposition April 2018, 46 (4) 367-379; DOI: https://doi.org/10.1124/dmd.117.078428
Sydor, Jens
- You have accessMetabolism and Disposition of a Novel Selective α7 Neuronal Acetylcholine Receptor Agonist ABT-126 in Humans: Characterization of the Major Roles for Flavin-Containing Monooxygenases and UDP-Glucuronosyl Transferase 1A4 and 2B10 in CatalysisHong Liu, David M. Stresser, Melissa J. Michmerhuizen, Xiaofeng Li, Ahmed A. Othman, Aimee D. Reed, Michael R. Schrimpf, Jens Sydor and Anthony J. LeeDrug Metabolism and Disposition April 2018, 46 (4) 429-439; DOI: https://doi.org/10.1124/dmd.117.077511
T
Taneja, Guncha
- You have accessRole of c-Jun-N-Terminal Kinase in Pregnane X Receptor-Mediated Induction of Human Cytochrome P4503A4 In VitroGuncha Taneja, Chun Chu, Paramahamsa Maturu, Bhagavatula Moorthy and Romi GhoseDrug Metabolism and Disposition April 2018, 46 (4) 397-404; DOI: https://doi.org/10.1124/dmd.117.079160
Tanner, Norman
- You have accessRegulation of Drug Metabolism by the Interplay of Inflammatory Signaling, Steatosis, and Xeno-Sensing Receptors in HepaRG CellsNorman Tanner, Lisa Kubik, Claudia Luckert, Maria Thomas, Ute Hofmann, Ulrich M. Zanger, Linda Böhmert, Alfonso Lampen and Albert BraeuningDrug Metabolism and Disposition April 2018, 46 (4) 326-335; DOI: https://doi.org/10.1124/dmd.117.078675
Tess, David
- You have accessComparison of Species and Cell-Type Differences in Fraction Unbound of Liver Tissues, Hepatocytes, and Cell LinesKeith Riccardi, Sangwoo Ryu, Jian Lin, Phillip Yates, David Tess, Rui Li, Dhirender Singh, Brian R. Holder, Brendon Kapinos, George Chang and Li DiDrug Metabolism and Disposition April 2018, 46 (4) 415-421; DOI: https://doi.org/10.1124/dmd.117.079152
Tess, David A.
- You have accessA Study on Pharmacokinetics of Bosentan with Systems Modeling, Part 1: Translating Systemic Plasma Concentration to Liver Exposure in Healthy SubjectsRui Li, Mark Niosi, Nathaniel Johnson, David A. Tess, Emi Kimoto, Jian Lin, Xin Yang, Keith A. Riccardi, Sangwoo Ryu, Ayman F. El-Kattan, Tristan S. Maurer, Larry M. Tremaine and Li DiDrug Metabolism and Disposition April 2018, 46 (4) 346-356; DOI: https://doi.org/10.1124/dmd.117.078790
- You have accessA Study on Pharmacokinetics of Bosentan with Systems Modeling, Part 2: Prospectively Predicting Systemic and Liver Exposure in Healthy SubjectsRui Li, Emi Kimoto, Mark Niosi, David A. Tess, Jian Lin, Larry M. Tremaine and Li DiDrug Metabolism and Disposition April 2018, 46 (4) 357-366; DOI: https://doi.org/10.1124/dmd.117.078808
Thomas, Maria
- You have accessRegulation of Drug Metabolism by the Interplay of Inflammatory Signaling, Steatosis, and Xeno-Sensing Receptors in HepaRG CellsNorman Tanner, Lisa Kubik, Claudia Luckert, Maria Thomas, Ute Hofmann, Ulrich M. Zanger, Linda Böhmert, Alfonso Lampen and Albert BraeuningDrug Metabolism and Disposition April 2018, 46 (4) 326-335; DOI: https://doi.org/10.1124/dmd.117.078675
Thornton, Timothy A.
- You have accessPolymorphic Human Sulfotransferase 2A1 Mediates the Formation of 25-Hydroxyvitamin D3-3-O-Sulfate, a Major Circulating Vitamin D Metabolite in HumansTimothy Wong, Zhican Wang, Brian D. Chapron, Mizuki Suzuki, Katrina G. Claw, Chunying Gao, Robert S. Foti, Bhagwat Prasad, Alenka Chapron, Justina Calamia, Amarjit Chaudhry, Erin G. Schuetz, Ronald L. Horst, Qingcheng Mao, Ian H. de Boer, Timothy A. Thornton and Kenneth E. ThummelDrug Metabolism and Disposition April 2018, 46 (4) 367-379; DOI: https://doi.org/10.1124/dmd.117.078428
Thummel, Kenneth E.
- You have accessPolymorphic Human Sulfotransferase 2A1 Mediates the Formation of 25-Hydroxyvitamin D3-3-O-Sulfate, a Major Circulating Vitamin D Metabolite in HumansTimothy Wong, Zhican Wang, Brian D. Chapron, Mizuki Suzuki, Katrina G. Claw, Chunying Gao, Robert S. Foti, Bhagwat Prasad, Alenka Chapron, Justina Calamia, Amarjit Chaudhry, Erin G. Schuetz, Ronald L. Horst, Qingcheng Mao, Ian H. de Boer, Timothy A. Thornton and Kenneth E. ThummelDrug Metabolism and Disposition April 2018, 46 (4) 367-379; DOI: https://doi.org/10.1124/dmd.117.078428
Totah, Rheem A.
- You have accessCYP2J2 Expression in Adult Ventricular Myocytes Protects Against Reactive Oxygen Species ToxicityEric A. Evangelista, Rozenn N. Lemaitre, Nona Sotoodehnia, Sina A. Gharib and Rheem A. TotahDrug Metabolism and Disposition April 2018, 46 (4) 380-386; DOI: https://doi.org/10.1124/dmd.117.078840
Tremaine, Larry M.
- You have accessA Study on Pharmacokinetics of Bosentan with Systems Modeling, Part 1: Translating Systemic Plasma Concentration to Liver Exposure in Healthy SubjectsRui Li, Mark Niosi, Nathaniel Johnson, David A. Tess, Emi Kimoto, Jian Lin, Xin Yang, Keith A. Riccardi, Sangwoo Ryu, Ayman F. El-Kattan, Tristan S. Maurer, Larry M. Tremaine and Li DiDrug Metabolism and Disposition April 2018, 46 (4) 346-356; DOI: https://doi.org/10.1124/dmd.117.078790
- You have accessA Study on Pharmacokinetics of Bosentan with Systems Modeling, Part 2: Prospectively Predicting Systemic and Liver Exposure in Healthy SubjectsRui Li, Emi Kimoto, Mark Niosi, David A. Tess, Jian Lin, Larry M. Tremaine and Li DiDrug Metabolism and Disposition April 2018, 46 (4) 357-366; DOI: https://doi.org/10.1124/dmd.117.078808
V
Vore, Mary
- You have accessPublishing in an ASPET Journal – What’s in It for You?Mary VoreDrug Metabolism and Disposition April 2018, 46 (4) 440-441; DOI: https://doi.org/10.1124/dmd.117.081034
W
Wang, Hui
- You have accessMaternal-Fetal Disposition and Metabolism of Retrorsine in Pregnant RatsXia Li, Xiaojing Yang, E Xiang, Jinyuan Luo, Shuaikai Qiu, Yan Fang, Li Zhang, Yu Guo, Jiang Zheng and Hui WangDrug Metabolism and Disposition April 2018, 46 (4) 422-428; DOI: https://doi.org/10.1124/dmd.117.079186
Wang, Zhican
- You have accessPolymorphic Human Sulfotransferase 2A1 Mediates the Formation of 25-Hydroxyvitamin D3-3-O-Sulfate, a Major Circulating Vitamin D Metabolite in HumansTimothy Wong, Zhican Wang, Brian D. Chapron, Mizuki Suzuki, Katrina G. Claw, Chunying Gao, Robert S. Foti, Bhagwat Prasad, Alenka Chapron, Justina Calamia, Amarjit Chaudhry, Erin G. Schuetz, Ronald L. Horst, Qingcheng Mao, Ian H. de Boer, Timothy A. Thornton and Kenneth E. ThummelDrug Metabolism and Disposition April 2018, 46 (4) 367-379; DOI: https://doi.org/10.1124/dmd.117.078428
Wegler, Christine
- Open AccessDirect Quantification of Cytochromes P450 and Drug Transporters—A Rapid, Targeted Mass Spectrometry-Based Immunoassay Panel for Tissues and Cell Culture LysatesFrederik Weiß, Helen S. Hammer, Kathrin Klein, Hannes Planatscher, Ulrich M. Zanger, Agneta Norén, Christine Wegler, Per Artursson, Thomas O. Joos and Oliver PoetzDrug Metabolism and Disposition April 2018, 46 (4) 387-396; DOI: https://doi.org/10.1124/dmd.117.078626
Weiß, Frederik
- Open AccessDirect Quantification of Cytochromes P450 and Drug Transporters—A Rapid, Targeted Mass Spectrometry-Based Immunoassay Panel for Tissues and Cell Culture LysatesFrederik Weiß, Helen S. Hammer, Kathrin Klein, Hannes Planatscher, Ulrich M. Zanger, Agneta Norén, Christine Wegler, Per Artursson, Thomas O. Joos and Oliver PoetzDrug Metabolism and Disposition April 2018, 46 (4) 387-396; DOI: https://doi.org/10.1124/dmd.117.078626
Wong, Siew Ying
- You have accessIdentification of Galeterone and Abiraterone as Inhibitors of Dehydroepiandrosterone Sulfonation Catalyzed by Human Hepatic Cytosol, SULT2A1, SULT2B1b, and SULT1E1Caleb Keng Yan Yip, Sumit Bansal, Siew Ying Wong and Aik Jiang LauDrug Metabolism and Disposition April 2018, 46 (4) 470-482; DOI: https://doi.org/10.1124/dmd.117.078980
Wong, Timothy
- You have accessPolymorphic Human Sulfotransferase 2A1 Mediates the Formation of 25-Hydroxyvitamin D3-3-O-Sulfate, a Major Circulating Vitamin D Metabolite in HumansTimothy Wong, Zhican Wang, Brian D. Chapron, Mizuki Suzuki, Katrina G. Claw, Chunying Gao, Robert S. Foti, Bhagwat Prasad, Alenka Chapron, Justina Calamia, Amarjit Chaudhry, Erin G. Schuetz, Ronald L. Horst, Qingcheng Mao, Ian H. de Boer, Timothy A. Thornton and Kenneth E. ThummelDrug Metabolism and Disposition April 2018, 46 (4) 367-379; DOI: https://doi.org/10.1124/dmd.117.078428
X
Xiang, E
- You have accessMaternal-Fetal Disposition and Metabolism of Retrorsine in Pregnant RatsXia Li, Xiaojing Yang, E Xiang, Jinyuan Luo, Shuaikai Qiu, Yan Fang, Li Zhang, Yu Guo, Jiang Zheng and Hui WangDrug Metabolism and Disposition April 2018, 46 (4) 422-428; DOI: https://doi.org/10.1124/dmd.117.079186
Xie, Cen
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- You have accessIdentification of Ketene-Reactive Intermediate of Erlotinib Possibly Responsible for Inactivation of P450 EnzymesHuimin Zhao, Siyuan Li, Zixin Yang, Ying Peng, Xiaohui Chen and Jiang ZhengDrug Metabolism and Disposition April 2018, 46 (4) 442-450; DOI: https://doi.org/10.1124/dmd.117.079327
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