Table of Contents

Special Section on Transporters in Drug Disposition and Pharmacokinetic Prediction

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  Drug Transporters in Xenobiotic Disposition and Pharmacokinetic Prediction

  Qingcheng Mao, Yurong Lai and Joanne Wang

  Drug Metabolism and Disposition May 2018, 46 (5) 561-566; DOI: https://doi.org/10.1124/dmd.118.081356
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  Beyond Competitive Inhibition: Regulation of ABC Transporters by Kinases and Protein-Protein Interactions as Potential Mechanisms of Drug-Drug Interactions

  Rebecca R. Crawford, Praveen K. Potukuchi, Erin G. Schuetz and John D. Schuetz

  Drug Metabolism and Disposition May 2018, 46 (5) 567-580; DOI: https://doi.org/10.1124/dmd.118.080663
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  Hepatic Transport of 25-Hydroxyvitamin D₃ Conjugates: A Mechanism of 25-Hydroxyvitamin D₃ Delivery to the Intestinal Tract

  Chunying Gao, Michael Z. Liao, Lyrialle W. Han, Kenneth E. Thummel and Qingcheng Mao

  Drug Metabolism and Disposition May 2018, 46 (5) 581-591; DOI: https://doi.org/10.1124/dmd.117.078881
• Open Access

  Expression of Organic Anion Transporter 1 or 3 in Human Kidney Proximal Tubule Cells Reduces Cisplatin Sensitivity

  Tom T. G. Nieskens, Janny G. P. Peters, Dina Dabaghie, Daphne Korte, Katja Jansen, Alexander H. Van Asbeck, Neslihan N. Tavraz, Thomas Friedrich, Frans G. M. Russel, Rosalinde Masereeuw and Martijn J. Wilmer

  Drug Metabolism and Disposition May 2018, 46 (5) 592-599; DOI: https://doi.org/10.1124/dmd.117.079384
• Open Access

  Identification of Structural and Molecular Features Involved in the Transport of 3′-Deoxy-Nucleoside Analogs by Human Equilibrative Nucleoside Transporter 3

  MD Fazlur Rahman, Radhika Raj and Rajgopal Govindarajan

  Drug Metabolism and Disposition May 2018, 46 (5) 600-609; DOI: https://doi.org/10.1124/dmd.117.079400
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  Liver Zonation Index of Drug Transporter and Metabolizing Enzyme Protein Expressions in Mouse Liver Acinus

  Masanori Tachikawa, Yuna Sumiyoshiya, Daisuke Saigusa, Kazunari Sasaki, Michitoshi Watanabe, Yasuo Uchida and Tetsuya Terasaki

  Drug Metabolism and Disposition May 2018, 46 (5) 610-618; DOI: https://doi.org/10.1124/dmd.117.079244
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  Interindividual Regulation of the Breast Cancer Resistance Protein/ABCG2 Transporter in Term Human Placentas

  Kristin M. Bircsak, Jamie E. Moscovitz, Xia Wen, Faith Archer, Poi Yu Sofia Yuen, Moiz Mohammed, Naureen Memon, Barry I. Weinberger, Laura M. Saba, Anna M. Vetrano and Lauren M. Aleksunes

  Drug Metabolism and Disposition May 2018, 46 (5) 619-627; DOI: https://doi.org/10.1124/dmd.117.079228
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  Interindividual Differences in the Expression of ATP-Binding Cassette and Solute Carrier Family Transporters in Human Skin: DNA Methylation Regulates Transcriptional Activity of the Human ABCC3 Gene

  Tomoki Takechi, Takeshi Hirota, Tatsuya Sakai, Natsumi Maeda, Daisuke Kobayashi and Ichiro Ieiri

  Drug Metabolism and Disposition May 2018, 46 (5) 628-635; DOI: https://doi.org/10.1124/dmd.117.079061
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  Rare Variants in the ABCG2 Promoter Modulate In Vivo Activity

  Rachel J. Eclov, Mee J. Kim, Robin Smith, Nadav Ahituv and Deanna L. Kroetz

  Drug Metabolism and Disposition May 2018, 46 (5) 636-642; DOI: https://doi.org/10.1124/dmd.117.079541
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  Identification of a NFκB Inhibition Site on the Proximal Promoter Region of Human Organic Anion Transporting Polypeptide 1A2 Coding Gene SLCO1A2

  Zhaojian Xiang, Weike Li, Lixue Wang, Jicai Yi, Kaiwen Chen and Mei Hong

  Drug Metabolism and Disposition May 2018, 46 (5) 643-651; DOI: https://doi.org/10.1124/dmd.117.078832
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  Organic Anion Transporting Polypeptide 1a4 is Responsible for the Hepatic Uptake of Cardiac Glycosides in Mice

  Junichi Takano, Kazuya Maeda, Hiroyuki Kusuhara and Yuichi Sugiyama

  Drug Metabolism and Disposition May 2018, 46 (5) 652-657; DOI: https://doi.org/10.1124/dmd.117.079483
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  Brain Distribution of a Novel MEK Inhibitor E6201: Implications in the Treatment of Melanoma Brain Metastases

  Gautham Gampa, Minjee Kim, Nicholas Cook-Rostie, Janice K. Laramy, Jann N. Sarkaria, Linda Paradiso, Louis DePalatis and William F. Elmquist

  Drug Metabolism and Disposition May 2018, 46 (5) 658-666; DOI: https://doi.org/10.1124/dmd.117.079194
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  Curcumin as an In Vivo Selective Intestinal Breast Cancer Resistance Protein Inhibitor in Cynomolgus Monkeys

  Tsuyoshi Karibe, Tomoki Imaoka, Koji Abe and Osamu Ando

  Drug Metabolism and Disposition May 2018, 46 (5) 667-679; DOI: https://doi.org/10.1124/dmd.117.078931
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  Sandwich-Cultured Hepatocytes for Mechanistic Understanding of Hepatic Disposition of Parent Drugs and Metabolites by Transporter–Enzyme Interplay

  Norikazu Matsunaga, Yukina Fukuchi, Haruo Imawaka and Ikumi Tamai

  Drug Metabolism and Disposition May 2018, 46 (5) 680-691; DOI: https://doi.org/10.1124/dmd.117.079236
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  Comparison of Proteomic Quantification Approaches for Hepatic Drug Transporters: Multiplexed Global Quantitation Correlates with Targeted Proteomic Quantitation

  Anna Vildhede, Chuong Nguyen, Brian K. Erickson, Ryan C. Kunz, Richard Jones, Emi Kimoto, Francis Bourbonais, A. David Rodrigues and Manthena V.S. Varma

  Drug Metabolism and Disposition May 2018, 46 (5) 692-696; DOI: https://doi.org/10.1124/dmd.117.079285
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  MRP2 Inhibition by HIV Protease Inhibitors in Rat and Human Hepatocytes: A Quantitative Confocal Microscopy Study

  Nico Holmstock, Marlies Oorts, Jan Snoeys and Pieter Annaert

  Drug Metabolism and Disposition May 2018, 46 (5) 697-703; DOI: https://doi.org/10.1124/dmd.117.079467
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  Intravital Multiphoton Microscopy with Fluorescent Bile Salts in Rats as an In Vivo Biomarker for Hepatobiliary Transport Inhibition

  Jennifer Ryan, Ryan E. Morgan, Yuan Chen, Laurie P. Volak, Robert T. Dunn and Kenneth W. Dunn

  Drug Metabolism and Disposition May 2018, 46 (5) 704-718; DOI: https://doi.org/10.1124/dmd.117.079277
• Open Access

  A Clinical Quantitative Evaluation of Hepatobiliary Transport of [¹¹C]Dehydropravastatin in Humans Using Positron Emission Tomography

  Ken-ichi Kaneko, Masaaki Tanaka, Akira Ishii, Yumiko Katayama, Takayoshi Nakaoka, Satsuki Irie, Hideki Kawahata, Takashi Yamanaga, Yasuhiro Wada, Takeshi Miyake, Kota Toshimoto, Kazuya Maeda, Yilong Cui, Masaru Enomoto, Etsushi Kawamura, Norifumi Kawada, Joji Kawabe, Susumu Shiomi, Hiroyuki Kusuhara, Yuichi Sugiyama and Yasuyoshi Watanabe

  Drug Metabolism and Disposition May 2018, 46 (5) 719-728; DOI: https://doi.org/10.1124/dmd.118.080408
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  Navigating Transporter Sciences in Pharmacokinetics Characterization Using the Extended Clearance Classification System

  Ayman F. El-Kattan and Manthena V. S. Varma

  Drug Metabolism and Disposition May 2018, 46 (5) 729-739; DOI: https://doi.org/10.1124/dmd.117.080044
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  Physiologically Based Pharmacokinetic Modeling of Bosentan Identifies the Saturable Hepatic Uptake As a Major Contributor to Its Nonlinear Pharmacokinetics

  Masanobu Sato, Kota Toshimoto, Atsuko Tomaru, Takashi Yoshikado, Yuta Tanaka, Akihiro Hisaka, Wooin Lee and Yuichi Sugiyama

  Drug Metabolism and Disposition May 2018, 46 (5) 740-748; DOI: https://doi.org/10.1124/dmd.117.078972
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  Evaluation of Alteration in Hepatic and Intestinal BCRP Function In Vivo from ABCG2 c.421C>A Polymorphism Based on PBPK Analysis of Rosuvastatin

  Azusa Futatsugi, Kota Toshimoto, Takashi Yoshikado, Yuichi Sugiyama and Yukio Kato

  Drug Metabolism and Disposition May 2018, 46 (5) 749-757; DOI: https://doi.org/10.1124/dmd.117.078816
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  Prediction of the Effects of Renal Impairment on Clearance for Organic Cation Drugs that Undergo Renal Secretion: A Simulation-Based Study

  Kristin E. Follman and Marilyn E. Morris

  Drug Metabolism and Disposition May 2018, 46 (5) 758-769; DOI: https://doi.org/10.1124/dmd.117.079558