Research ArticleSpecial Section on Transporters in Drug Disposition and Pharmacokinetic Prediction
Open Access
A Clinical Quantitative Evaluation of Hepatobiliary Transport of [11C]Dehydropravastatin in Humans Using Positron Emission Tomography
Ken-ichi Kaneko, Masaaki Tanaka, Akira Ishii, Yumiko Katayama, Takayoshi Nakaoka, Satsuki Irie, Hideki Kawahata, Takashi Yamanaga, Yasuhiro Wada, Takeshi Miyake, Kota Toshimoto, Kazuya Maeda, Yilong Cui, Masaru Enomoto, Etsushi Kawamura, Norifumi Kawada, Joji Kawabe, Susumu Shiomi, Hiroyuki Kusuhara, Yuichi Sugiyama and Yasuyoshi Watanabe
Drug Metabolism and Disposition May 2018, 46 (5) 719-728; DOI: https://doi.org/10.1124/dmd.118.080408
Ken-ichi Kaneko
RIKEN Center for Life Science Technologies (K.K., Y.K., T.N., S.I., Y.Wad., Y.C., Y.Wat.) and RIKEN Center for Molecular Imaging Sciences (Y.K., Y.Wad., Y.C., Y.Wat.), Chuo-ku, Kobe, Hyogo, Japan; Departments of Physiology, Nuclear Medicine, and Hepatology, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka, Japan (M.T., A.I., H.K., T.Y., M.E., E.K., N.K., J.K., S.S.); Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, the University of Tokyo, Bunkyo-ku, Tokyo, Japan (T.M., K.M., H.K.); and Sugiyama Laboratory, RIKEN Innovation Center, RIKEN, Tsurumi-ku, Yokohama, Kanagawa, Japan (K.T., Y.S.)
Masaaki Tanaka
RIKEN Center for Life Science Technologies (K.K., Y.K., T.N., S.I., Y.Wad., Y.C., Y.Wat.) and RIKEN Center for Molecular Imaging Sciences (Y.K., Y.Wad., Y.C., Y.Wat.), Chuo-ku, Kobe, Hyogo, Japan; Departments of Physiology, Nuclear Medicine, and Hepatology, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka, Japan (M.T., A.I., H.K., T.Y., M.E., E.K., N.K., J.K., S.S.); Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, the University of Tokyo, Bunkyo-ku, Tokyo, Japan (T.M., K.M., H.K.); and Sugiyama Laboratory, RIKEN Innovation Center, RIKEN, Tsurumi-ku, Yokohama, Kanagawa, Japan (K.T., Y.S.)
Akira Ishii
RIKEN Center for Life Science Technologies (K.K., Y.K., T.N., S.I., Y.Wad., Y.C., Y.Wat.) and RIKEN Center for Molecular Imaging Sciences (Y.K., Y.Wad., Y.C., Y.Wat.), Chuo-ku, Kobe, Hyogo, Japan; Departments of Physiology, Nuclear Medicine, and Hepatology, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka, Japan (M.T., A.I., H.K., T.Y., M.E., E.K., N.K., J.K., S.S.); Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, the University of Tokyo, Bunkyo-ku, Tokyo, Japan (T.M., K.M., H.K.); and Sugiyama Laboratory, RIKEN Innovation Center, RIKEN, Tsurumi-ku, Yokohama, Kanagawa, Japan (K.T., Y.S.)
Yumiko Katayama
RIKEN Center for Life Science Technologies (K.K., Y.K., T.N., S.I., Y.Wad., Y.C., Y.Wat.) and RIKEN Center for Molecular Imaging Sciences (Y.K., Y.Wad., Y.C., Y.Wat.), Chuo-ku, Kobe, Hyogo, Japan; Departments of Physiology, Nuclear Medicine, and Hepatology, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka, Japan (M.T., A.I., H.K., T.Y., M.E., E.K., N.K., J.K., S.S.); Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, the University of Tokyo, Bunkyo-ku, Tokyo, Japan (T.M., K.M., H.K.); and Sugiyama Laboratory, RIKEN Innovation Center, RIKEN, Tsurumi-ku, Yokohama, Kanagawa, Japan (K.T., Y.S.)
Takayoshi Nakaoka
RIKEN Center for Life Science Technologies (K.K., Y.K., T.N., S.I., Y.Wad., Y.C., Y.Wat.) and RIKEN Center for Molecular Imaging Sciences (Y.K., Y.Wad., Y.C., Y.Wat.), Chuo-ku, Kobe, Hyogo, Japan; Departments of Physiology, Nuclear Medicine, and Hepatology, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka, Japan (M.T., A.I., H.K., T.Y., M.E., E.K., N.K., J.K., S.S.); Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, the University of Tokyo, Bunkyo-ku, Tokyo, Japan (T.M., K.M., H.K.); and Sugiyama Laboratory, RIKEN Innovation Center, RIKEN, Tsurumi-ku, Yokohama, Kanagawa, Japan (K.T., Y.S.)
Satsuki Irie
RIKEN Center for Life Science Technologies (K.K., Y.K., T.N., S.I., Y.Wad., Y.C., Y.Wat.) and RIKEN Center for Molecular Imaging Sciences (Y.K., Y.Wad., Y.C., Y.Wat.), Chuo-ku, Kobe, Hyogo, Japan; Departments of Physiology, Nuclear Medicine, and Hepatology, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka, Japan (M.T., A.I., H.K., T.Y., M.E., E.K., N.K., J.K., S.S.); Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, the University of Tokyo, Bunkyo-ku, Tokyo, Japan (T.M., K.M., H.K.); and Sugiyama Laboratory, RIKEN Innovation Center, RIKEN, Tsurumi-ku, Yokohama, Kanagawa, Japan (K.T., Y.S.)
Hideki Kawahata
RIKEN Center for Life Science Technologies (K.K., Y.K., T.N., S.I., Y.Wad., Y.C., Y.Wat.) and RIKEN Center for Molecular Imaging Sciences (Y.K., Y.Wad., Y.C., Y.Wat.), Chuo-ku, Kobe, Hyogo, Japan; Departments of Physiology, Nuclear Medicine, and Hepatology, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka, Japan (M.T., A.I., H.K., T.Y., M.E., E.K., N.K., J.K., S.S.); Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, the University of Tokyo, Bunkyo-ku, Tokyo, Japan (T.M., K.M., H.K.); and Sugiyama Laboratory, RIKEN Innovation Center, RIKEN, Tsurumi-ku, Yokohama, Kanagawa, Japan (K.T., Y.S.)
Takashi Yamanaga
RIKEN Center for Life Science Technologies (K.K., Y.K., T.N., S.I., Y.Wad., Y.C., Y.Wat.) and RIKEN Center for Molecular Imaging Sciences (Y.K., Y.Wad., Y.C., Y.Wat.), Chuo-ku, Kobe, Hyogo, Japan; Departments of Physiology, Nuclear Medicine, and Hepatology, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka, Japan (M.T., A.I., H.K., T.Y., M.E., E.K., N.K., J.K., S.S.); Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, the University of Tokyo, Bunkyo-ku, Tokyo, Japan (T.M., K.M., H.K.); and Sugiyama Laboratory, RIKEN Innovation Center, RIKEN, Tsurumi-ku, Yokohama, Kanagawa, Japan (K.T., Y.S.)
Yasuhiro Wada
RIKEN Center for Life Science Technologies (K.K., Y.K., T.N., S.I., Y.Wad., Y.C., Y.Wat.) and RIKEN Center for Molecular Imaging Sciences (Y.K., Y.Wad., Y.C., Y.Wat.), Chuo-ku, Kobe, Hyogo, Japan; Departments of Physiology, Nuclear Medicine, and Hepatology, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka, Japan (M.T., A.I., H.K., T.Y., M.E., E.K., N.K., J.K., S.S.); Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, the University of Tokyo, Bunkyo-ku, Tokyo, Japan (T.M., K.M., H.K.); and Sugiyama Laboratory, RIKEN Innovation Center, RIKEN, Tsurumi-ku, Yokohama, Kanagawa, Japan (K.T., Y.S.)
Takeshi Miyake
RIKEN Center for Life Science Technologies (K.K., Y.K., T.N., S.I., Y.Wad., Y.C., Y.Wat.) and RIKEN Center for Molecular Imaging Sciences (Y.K., Y.Wad., Y.C., Y.Wat.), Chuo-ku, Kobe, Hyogo, Japan; Departments of Physiology, Nuclear Medicine, and Hepatology, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka, Japan (M.T., A.I., H.K., T.Y., M.E., E.K., N.K., J.K., S.S.); Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, the University of Tokyo, Bunkyo-ku, Tokyo, Japan (T.M., K.M., H.K.); and Sugiyama Laboratory, RIKEN Innovation Center, RIKEN, Tsurumi-ku, Yokohama, Kanagawa, Japan (K.T., Y.S.)
Kota Toshimoto
RIKEN Center for Life Science Technologies (K.K., Y.K., T.N., S.I., Y.Wad., Y.C., Y.Wat.) and RIKEN Center for Molecular Imaging Sciences (Y.K., Y.Wad., Y.C., Y.Wat.), Chuo-ku, Kobe, Hyogo, Japan; Departments of Physiology, Nuclear Medicine, and Hepatology, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka, Japan (M.T., A.I., H.K., T.Y., M.E., E.K., N.K., J.K., S.S.); Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, the University of Tokyo, Bunkyo-ku, Tokyo, Japan (T.M., K.M., H.K.); and Sugiyama Laboratory, RIKEN Innovation Center, RIKEN, Tsurumi-ku, Yokohama, Kanagawa, Japan (K.T., Y.S.)
Kazuya Maeda
RIKEN Center for Life Science Technologies (K.K., Y.K., T.N., S.I., Y.Wad., Y.C., Y.Wat.) and RIKEN Center for Molecular Imaging Sciences (Y.K., Y.Wad., Y.C., Y.Wat.), Chuo-ku, Kobe, Hyogo, Japan; Departments of Physiology, Nuclear Medicine, and Hepatology, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka, Japan (M.T., A.I., H.K., T.Y., M.E., E.K., N.K., J.K., S.S.); Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, the University of Tokyo, Bunkyo-ku, Tokyo, Japan (T.M., K.M., H.K.); and Sugiyama Laboratory, RIKEN Innovation Center, RIKEN, Tsurumi-ku, Yokohama, Kanagawa, Japan (K.T., Y.S.)
Yilong Cui
RIKEN Center for Life Science Technologies (K.K., Y.K., T.N., S.I., Y.Wad., Y.C., Y.Wat.) and RIKEN Center for Molecular Imaging Sciences (Y.K., Y.Wad., Y.C., Y.Wat.), Chuo-ku, Kobe, Hyogo, Japan; Departments of Physiology, Nuclear Medicine, and Hepatology, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka, Japan (M.T., A.I., H.K., T.Y., M.E., E.K., N.K., J.K., S.S.); Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, the University of Tokyo, Bunkyo-ku, Tokyo, Japan (T.M., K.M., H.K.); and Sugiyama Laboratory, RIKEN Innovation Center, RIKEN, Tsurumi-ku, Yokohama, Kanagawa, Japan (K.T., Y.S.)
Masaru Enomoto
RIKEN Center for Life Science Technologies (K.K., Y.K., T.N., S.I., Y.Wad., Y.C., Y.Wat.) and RIKEN Center for Molecular Imaging Sciences (Y.K., Y.Wad., Y.C., Y.Wat.), Chuo-ku, Kobe, Hyogo, Japan; Departments of Physiology, Nuclear Medicine, and Hepatology, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka, Japan (M.T., A.I., H.K., T.Y., M.E., E.K., N.K., J.K., S.S.); Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, the University of Tokyo, Bunkyo-ku, Tokyo, Japan (T.M., K.M., H.K.); and Sugiyama Laboratory, RIKEN Innovation Center, RIKEN, Tsurumi-ku, Yokohama, Kanagawa, Japan (K.T., Y.S.)
Etsushi Kawamura
RIKEN Center for Life Science Technologies (K.K., Y.K., T.N., S.I., Y.Wad., Y.C., Y.Wat.) and RIKEN Center for Molecular Imaging Sciences (Y.K., Y.Wad., Y.C., Y.Wat.), Chuo-ku, Kobe, Hyogo, Japan; Departments of Physiology, Nuclear Medicine, and Hepatology, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka, Japan (M.T., A.I., H.K., T.Y., M.E., E.K., N.K., J.K., S.S.); Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, the University of Tokyo, Bunkyo-ku, Tokyo, Japan (T.M., K.M., H.K.); and Sugiyama Laboratory, RIKEN Innovation Center, RIKEN, Tsurumi-ku, Yokohama, Kanagawa, Japan (K.T., Y.S.)
Norifumi Kawada
RIKEN Center for Life Science Technologies (K.K., Y.K., T.N., S.I., Y.Wad., Y.C., Y.Wat.) and RIKEN Center for Molecular Imaging Sciences (Y.K., Y.Wad., Y.C., Y.Wat.), Chuo-ku, Kobe, Hyogo, Japan; Departments of Physiology, Nuclear Medicine, and Hepatology, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka, Japan (M.T., A.I., H.K., T.Y., M.E., E.K., N.K., J.K., S.S.); Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, the University of Tokyo, Bunkyo-ku, Tokyo, Japan (T.M., K.M., H.K.); and Sugiyama Laboratory, RIKEN Innovation Center, RIKEN, Tsurumi-ku, Yokohama, Kanagawa, Japan (K.T., Y.S.)
Joji Kawabe
RIKEN Center for Life Science Technologies (K.K., Y.K., T.N., S.I., Y.Wad., Y.C., Y.Wat.) and RIKEN Center for Molecular Imaging Sciences (Y.K., Y.Wad., Y.C., Y.Wat.), Chuo-ku, Kobe, Hyogo, Japan; Departments of Physiology, Nuclear Medicine, and Hepatology, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka, Japan (M.T., A.I., H.K., T.Y., M.E., E.K., N.K., J.K., S.S.); Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, the University of Tokyo, Bunkyo-ku, Tokyo, Japan (T.M., K.M., H.K.); and Sugiyama Laboratory, RIKEN Innovation Center, RIKEN, Tsurumi-ku, Yokohama, Kanagawa, Japan (K.T., Y.S.)
Susumu Shiomi
RIKEN Center for Life Science Technologies (K.K., Y.K., T.N., S.I., Y.Wad., Y.C., Y.Wat.) and RIKEN Center for Molecular Imaging Sciences (Y.K., Y.Wad., Y.C., Y.Wat.), Chuo-ku, Kobe, Hyogo, Japan; Departments of Physiology, Nuclear Medicine, and Hepatology, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka, Japan (M.T., A.I., H.K., T.Y., M.E., E.K., N.K., J.K., S.S.); Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, the University of Tokyo, Bunkyo-ku, Tokyo, Japan (T.M., K.M., H.K.); and Sugiyama Laboratory, RIKEN Innovation Center, RIKEN, Tsurumi-ku, Yokohama, Kanagawa, Japan (K.T., Y.S.)
Hiroyuki Kusuhara
RIKEN Center for Life Science Technologies (K.K., Y.K., T.N., S.I., Y.Wad., Y.C., Y.Wat.) and RIKEN Center for Molecular Imaging Sciences (Y.K., Y.Wad., Y.C., Y.Wat.), Chuo-ku, Kobe, Hyogo, Japan; Departments of Physiology, Nuclear Medicine, and Hepatology, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka, Japan (M.T., A.I., H.K., T.Y., M.E., E.K., N.K., J.K., S.S.); Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, the University of Tokyo, Bunkyo-ku, Tokyo, Japan (T.M., K.M., H.K.); and Sugiyama Laboratory, RIKEN Innovation Center, RIKEN, Tsurumi-ku, Yokohama, Kanagawa, Japan (K.T., Y.S.)
Yuichi Sugiyama
RIKEN Center for Life Science Technologies (K.K., Y.K., T.N., S.I., Y.Wad., Y.C., Y.Wat.) and RIKEN Center for Molecular Imaging Sciences (Y.K., Y.Wad., Y.C., Y.Wat.), Chuo-ku, Kobe, Hyogo, Japan; Departments of Physiology, Nuclear Medicine, and Hepatology, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka, Japan (M.T., A.I., H.K., T.Y., M.E., E.K., N.K., J.K., S.S.); Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, the University of Tokyo, Bunkyo-ku, Tokyo, Japan (T.M., K.M., H.K.); and Sugiyama Laboratory, RIKEN Innovation Center, RIKEN, Tsurumi-ku, Yokohama, Kanagawa, Japan (K.T., Y.S.)
Yasuyoshi Watanabe
RIKEN Center for Life Science Technologies (K.K., Y.K., T.N., S.I., Y.Wad., Y.C., Y.Wat.) and RIKEN Center for Molecular Imaging Sciences (Y.K., Y.Wad., Y.C., Y.Wat.), Chuo-ku, Kobe, Hyogo, Japan; Departments of Physiology, Nuclear Medicine, and Hepatology, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka, Japan (M.T., A.I., H.K., T.Y., M.E., E.K., N.K., J.K., S.S.); Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, the University of Tokyo, Bunkyo-ku, Tokyo, Japan (T.M., K.M., H.K.); and Sugiyama Laboratory, RIKEN Innovation Center, RIKEN, Tsurumi-ku, Yokohama, Kanagawa, Japan (K.T., Y.S.)
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In this issue
Research ArticleSpecial Section on Transporters in Drug Disposition and Pharmacokinetic Prediction
Human PET Study on Functional Analysis of OATP1Bs and MRP2
Ken-ichi Kaneko, Masaaki Tanaka, Akira Ishii, Yumiko Katayama, Takayoshi Nakaoka, Satsuki Irie, Hideki Kawahata, Takashi Yamanaga, Yasuhiro Wada, Takeshi Miyake, Kota Toshimoto, Kazuya Maeda, Yilong Cui, Masaru Enomoto, Etsushi Kawamura, Norifumi Kawada, Joji Kawabe, Susumu Shiomi, Hiroyuki Kusuhara, Yuichi Sugiyama and Yasuyoshi Watanabe
Drug Metabolism and Disposition May 1, 2018, 46 (5) 719-728; DOI: https://doi.org/10.1124/dmd.118.080408
Research ArticleSpecial Section on Transporters in Drug Disposition and Pharmacokinetic Prediction
Human PET Study on Functional Analysis of OATP1Bs and MRP2
Ken-ichi Kaneko, Masaaki Tanaka, Akira Ishii, Yumiko Katayama, Takayoshi Nakaoka, Satsuki Irie, Hideki Kawahata, Takashi Yamanaga, Yasuhiro Wada, Takeshi Miyake, Kota Toshimoto, Kazuya Maeda, Yilong Cui, Masaru Enomoto, Etsushi Kawamura, Norifumi Kawada, Joji Kawabe, Susumu Shiomi, Hiroyuki Kusuhara, Yuichi Sugiyama and Yasuyoshi Watanabe
Drug Metabolism and Disposition May 1, 2018, 46 (5) 719-728; DOI: https://doi.org/10.1124/dmd.118.080408
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