Structure-Activity Relationships of the Main Bioactive Constituents of Euodia rutaecarpa on Aryl Hydrocarbon Receptor Activation and Associated Bile Acid Homeostasis

Youbo Zhang; Tingting Yan; Dongxue Sun; Cen Xie; Yiran Zheng; Lei Zhang; Tomoki Yagai; Kristopher W. Krausz; William H. Bisson; Xiuwei Yang; Frank J. Gonzalez

doi:10.1124/dmd.117.080176

Research ArticleArticle

Structure-Activity Relationships of the Main Bioactive Constituents of Euodia rutaecarpa on Aryl Hydrocarbon Receptor Activation and Associated Bile Acid Homeostasis

Youbo Zhang, Tingting Yan, Dongxue Sun, Cen Xie, Yiran Zheng, Lei Zhang, Tomoki Yagai, Kristopher W. Krausz, William H. Bisson, Xiuwei Yang and Frank J. Gonzalez

Drug Metabolism and Disposition July 2018, 46 (7) 1030-1040; DOI: https://doi.org/10.1124/dmd.117.080176

Youbo Zhang

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (Yo.Z., Ti.Y., D.S. C.X., To.Y., K.W.K., F.J.G.); State Key Laboratory of Natural and Biomimetic Drugs and Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing, China (Yo.Z., Yi.Z., L.Z., X.Y.); Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, Oregon (W.H.B.); and College of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang, Liaoning, China (D.S.)

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Tingting Yan

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Dongxue Sun

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Cen Xie

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Yiran Zheng

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Lei Zhang

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Tomoki Yagai

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Kristopher W. Krausz

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William H. Bisson

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Xiuwei Yang

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For correspondence: xwyang@bjmu.edu.cn

Frank J. Gonzalez

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For correspondence: gonzalef@mail.nih.gov

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Drug Metabolism and Disposition

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1 Jul 2018

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Research ArticleArticle

AHR and Bioactive Constituents of Euodia rutaecarpa

Youbo Zhang, Tingting Yan, Dongxue Sun, Cen Xie, Yiran Zheng, Lei Zhang, Tomoki Yagai, Kristopher W. Krausz, William H. Bisson, Xiuwei Yang and Frank J. Gonzalez

Drug Metabolism and Disposition July 1, 2018, 46 (7) 1030-1040; DOI: https://doi.org/10.1124/dmd.117.080176

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Research ArticleArticle

AHR and Bioactive Constituents of Euodia rutaecarpa

Youbo Zhang, Tingting Yan, Dongxue Sun, Cen Xie, Yiran Zheng, Lei Zhang, Tomoki Yagai, Kristopher W. Krausz, William H. Bisson, Xiuwei Yang and Frank J. Gonzalez

Drug Metabolism and Disposition July 1, 2018, 46 (7) 1030-1040; DOI: https://doi.org/10.1124/dmd.117.080176

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