CYP1A2 | Phenacetin | 112.7 ± 10.9 | 100 | Acetaminophen | 152.0 > 109.7 (+) |
CYP2A6 | Coumarin | 1.5 ± 0.2 | 1.5 | 7-Hydroxycoumarin | 161.1 > 133.2 (−) |
CYP2B6 | Bupropion | 125.2 ± 14.0 | 12 | Hydroxybupropion | 256.1 > 138.8 (+) |
CYP2C8 | Amodiaquine | 1.0 ± 0.1 | 1 | N-desethylamodiaquine | 328.1 > 282.9 (+) |
CYP2C9 | Tolbutamide | 110.7 ± 11.6 | 100 | Hydroxytolbutamide | 285.1 > 186.2 (−) |
CYP2C19 | (S)-mephenytoin | 52.5 ± 10.6 | 50 | (±)-4′Hydroxymephenytoin | 235.0 > 132.6 (+) |
CYP2D6 | Dextromethorphan | 2.9 ± 0.5 | 2.5 | Dextrophan | 258.1 > 157.2 (+) |
CYP2E1 | Chlorzoxazone | 149.8 ± 12.6 | 15 | 6-Hydroxychlorzoxazone | 186.0 > 119.7 (−) |
CYP3A4/5 | Midazolam | 2.7 ± 0.1 | 2.5 | 1′-Hydroxymidazolam | 342.0 > 324.0 (+) |
| Testosterone | 50.5 ± 5.6 | 50 | 6β-Hydroxytestosterone | 304.8 > 268.9 (+) |
| Orphenadrine (internal standard) | | | 270.8 > 180.9 (+) |