Elucidation of N1-methyladenosine as a Potential Surrogate Biomarker for Drug Interaction Studies Involving Renal Organic Cation Transporters

Takeshi Miyake; Tadahaya Mizuno; Issey Takehara; Tatsuki Mochizuki; Miyuki Kimura; Shunji Matsuki; Shin Irie; Nobuaki Watanabe; Yukio Kato; Ichiro Ieiri; Kazuya Maeda; Osamu Ando; Hiroyuki Kusuhara

doi:10.1124/dmd.119.087262

Research ArticleArticle

Elucidation of N¹-methyladenosine as a Potential Surrogate Biomarker for Drug Interaction Studies Involving Renal Organic Cation Transporters

Takeshi Miyake, Tadahaya Mizuno, Issey Takehara, Tatsuki Mochizuki, Miyuki Kimura, Shunji Matsuki, Shin Irie, Nobuaki Watanabe, Yukio Kato, Ichiro Ieiri, Kazuya Maeda, Osamu Ando and Hiroyuki Kusuhara

Drug Metabolism and Disposition November 2019, 47 (11) 1270-1280; DOI: https://doi.org/10.1124/dmd.119.087262

Takeshi Miyake

Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, the University of Tokyo, Tokyo, Japan (Tak.M., Tad.M., Tat.M., K.M., H.K.); Biomarker Department (I.T.) and Drug Metabolism & Pharmacokinetics Research Laboratories (N.W., O.A.), Daiichi-Sankyo Co., Ltd., Tokyo, Japan; Fukuoka Mirai Hospital Clinical Research Center, Fukuoka, Japan (M.K., S.M., S.I.); Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan (Y.K.); and Department of Clinical Pharmacokinetics, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan (I.I.)

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Tadahaya Mizuno

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Issey Takehara

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Tatsuki Mochizuki

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Miyuki Kimura

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Shunji Matsuki

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Shin Irie

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Nobuaki Watanabe

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Yukio Kato

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Ichiro Ieiri

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Kazuya Maeda

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Osamu Ando

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Hiroyuki Kusuhara

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Drug Metabolism and Disposition

Vol. 47, Issue 11

1 Nov 2019

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