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Supplementary Methods
Supplementary Figure 1 - Representative extracted ion chromatograms for PTX (a) and PTX-M (b).
Supplementary Figure 2 - Specificity of Fmo5 in generating PTX-M from PTX assessed by incubation of PTX (500 muM) with Fmo-transfected or control cells.
Supplementary Figure 3 - qPCR analyses of hepatic Rev-erbα, E4bp4, and Dbp mRNA levels in Bmal1-/- mice.
Supplementary Figure 4 - Schematic representation of E-box and D-box elements in Fmo1-4 promoter regions.
Supplementary Figure 5 - qPCR analyses of hepatic Fmo5 mRNA levels in Clock-/-mice.
Supplementary Reference
- Supplemental Data -