Table of Contents

Articles

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  Development and Characterization of MDR1 (Mdr1a/b) CRISPR/Cas9 Knockout Rat Model

  Chenmeizi Liang, Junfang Zhao, Jian Lu, Yuanjin Zhang, Xinrun Ma, Xuyang Shang, Yongmei Li, Xueyun Ma, Mingyao Liu and Xin Wang

  Drug Metabolism and Disposition February 2019, 47 (2) 71-79; DOI: https://doi.org/10.1124/dmd.118.084277
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  Serotonin Receptors of 5-HT₂ Type in the Hypothalamic Arcuate Nuclei Positively Regulate Liver Cytochrome P450 via Stimulation of the Growth Hormone–Releasing Hormone/Growth Hormone Hormonal Pathway

  Ewa Bromek, Marta Rysz, Anna Haduch and Władysława A. Daniel

  Drug Metabolism and Disposition February 2019, 47 (2) 80-85; DOI: https://doi.org/10.1124/dmd.118.083808
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  Berberine Directly Affects the Gut Microbiota to Promote Intestinal Farnesoid X Receptor Activation

  Yuan Tian, Jingwei Cai, Wei Gui, Robert G. Nichols, Imhoi Koo, Jingtao Zhang, Mallappa Anitha and Andrew D. Patterson

  Drug Metabolism and Disposition February 2019, 47 (2) 86-93; DOI: https://doi.org/10.1124/dmd.118.083691
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  Extrapolation of In Vivo Hepatic Clearance from In Vitro Uptake Clearance by Suspended Human Hepatocytes for Anionic Drugs with High Binding to Human Albumin: Improvement of In Vitro-to-In Vivo Extrapolation by Considering the “Albumin-Mediated” Hepatic Uptake Mechanism on the Basis of the “Facilitated-Dissociation Model”

  Soo-Jin Kim, Kyeong-Ryoon Lee, Seiji Miyauchi and Yuichi Sugiyama

  Drug Metabolism and Disposition February 2019, 47 (2) 94-103; DOI: https://doi.org/10.1124/dmd.118.083733
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  Characterization of Stereoselective Metabolism, Inhibitory Effect on Uric Acid Uptake Transporters, and Pharmacokinetics of Lesinurad Atropisomers

  Chun Yang, Dongmei Zhou, Zancong Shen, David M. Wilson, Matthew Renner, Jeffrey N. Miner, Jean-Luc Girardet and Caroline A. Lee

  Drug Metabolism and Disposition February 2019, 47 (2) 104-113; DOI: https://doi.org/10.1124/dmd.118.080549
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  Prediction of Human Distribution Volumes of Compounds in Various Elimination Phases Using Physiologically Based Pharmacokinetic Modeling and Experimental Pharmacokinetics in Animals

  Hidetoshi Shimizu, Kosuke Yoshida, Tomohisa Nakada, Koki Kojima, Akihito Ogasawara, Yoshinobu Nakamaru and Hiroshi Yamazaki

  Drug Metabolism and Disposition February 2019, 47 (2) 114-123; DOI: https://doi.org/10.1124/dmd.118.083642
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  Optimization of Experimental Conditions of Automated Glucuronidation Assays in Human Liver Microsomes Using a Cocktail Approach and Ultra-High Performance Liquid Chromatography–Tandem Mass Spectrometry

  Justine Badée, Nahong Qiu, Neil Parrott, Abby C. Collier, Stephan Schmidt and Stephen Fowler

  Drug Metabolism and Disposition February 2019, 47 (2) 124-134; DOI: https://doi.org/10.1124/dmd.118.084301
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  Bioavailability, Biotransformation, and Excretion of the Covalent Bruton Tyrosine Kinase Inhibitor Acalabrutinib in Rats, Dogs, and Humans

  Terry Podoll, Paul G. Pearson, Jerry Evarts, Tim Ingallinera, Elena Bibikova, Hao Sun, Mark Gohdes, Kristen Cardinal, Mitesh Sanghvi and J. Greg Slatter

  Drug Metabolism and Disposition February 2019, 47 (2) 145-154; DOI: https://doi.org/10.1124/dmd.118.084459
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  Altered Hepatobiliary Disposition of Tolvaptan and Selected Tolvaptan Metabolites in a Rodent Model of Polycystic Kidney Disease

  James J. Beaudoin, Jacqueline Bezençon, Yanguang Cao, Katsuhiko Mizuno, Sharin E. Roth, William J. Brock and Kim L. R. Brouwer

  Drug Metabolism and Disposition February 2019, 47 (2) 155-163; DOI: https://doi.org/10.1124/dmd.118.083907
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  Overcoming P-Glycoprotein–Mediated Drug Resistance with Noscapine Derivatives

  Divya Muthiah, Georgia K. Henshaw, Aaron J. DeBono, Ben Capuano, Peter J. Scammells and Richard Callaghan

  Drug Metabolism and Disposition February 2019, 47 (2) 164-172; DOI: https://doi.org/10.1124/dmd.118.083188