Research ArticleArticle
Modeling of Hepatic Drug Metabolism and Responses in CYP2C19 Poor Metabolizer Using Genetically Manipulated Human iPS cells
Sayaka Deguchi, Tomoki Yamashita, Keisuke Igai, Kazuo Harada, Yukiko Toba, Kazumasa Hirata, Kazuo Takayama and Hiroyuki Mizuguchi
Drug Metabolism and Disposition June 2019, 47 (6) 632-638; DOI: https://doi.org/10.1124/dmd.119.086322
Sayaka Deguchi
Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences (S.D., T.Y., K.I., Y.T., K.T., H.M.), Laboratory of Applied Environmental Biology, Graduate School of Pharmaceutical Sciences (K.Ha., K.Hi.), and Global Center for Medical Engineering and Informatics (H.M.), Osaka University, Osaka, Japan; PRESTO, Japan Science and Technology Agency, Saitama, Japan (K.T.); and Laboratory of Hepatocyte Regulation, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan (Y.T., K.T., H.M.)
Tomoki Yamashita
Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences (S.D., T.Y., K.I., Y.T., K.T., H.M.), Laboratory of Applied Environmental Biology, Graduate School of Pharmaceutical Sciences (K.Ha., K.Hi.), and Global Center for Medical Engineering and Informatics (H.M.), Osaka University, Osaka, Japan; PRESTO, Japan Science and Technology Agency, Saitama, Japan (K.T.); and Laboratory of Hepatocyte Regulation, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan (Y.T., K.T., H.M.)
Keisuke Igai
Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences (S.D., T.Y., K.I., Y.T., K.T., H.M.), Laboratory of Applied Environmental Biology, Graduate School of Pharmaceutical Sciences (K.Ha., K.Hi.), and Global Center for Medical Engineering and Informatics (H.M.), Osaka University, Osaka, Japan; PRESTO, Japan Science and Technology Agency, Saitama, Japan (K.T.); and Laboratory of Hepatocyte Regulation, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan (Y.T., K.T., H.M.)
Kazuo Harada
Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences (S.D., T.Y., K.I., Y.T., K.T., H.M.), Laboratory of Applied Environmental Biology, Graduate School of Pharmaceutical Sciences (K.Ha., K.Hi.), and Global Center for Medical Engineering and Informatics (H.M.), Osaka University, Osaka, Japan; PRESTO, Japan Science and Technology Agency, Saitama, Japan (K.T.); and Laboratory of Hepatocyte Regulation, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan (Y.T., K.T., H.M.)
Yukiko Toba
Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences (S.D., T.Y., K.I., Y.T., K.T., H.M.), Laboratory of Applied Environmental Biology, Graduate School of Pharmaceutical Sciences (K.Ha., K.Hi.), and Global Center for Medical Engineering and Informatics (H.M.), Osaka University, Osaka, Japan; PRESTO, Japan Science and Technology Agency, Saitama, Japan (K.T.); and Laboratory of Hepatocyte Regulation, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan (Y.T., K.T., H.M.)
Kazumasa Hirata
Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences (S.D., T.Y., K.I., Y.T., K.T., H.M.), Laboratory of Applied Environmental Biology, Graduate School of Pharmaceutical Sciences (K.Ha., K.Hi.), and Global Center for Medical Engineering and Informatics (H.M.), Osaka University, Osaka, Japan; PRESTO, Japan Science and Technology Agency, Saitama, Japan (K.T.); and Laboratory of Hepatocyte Regulation, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan (Y.T., K.T., H.M.)
Kazuo Takayama
Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences (S.D., T.Y., K.I., Y.T., K.T., H.M.), Laboratory of Applied Environmental Biology, Graduate School of Pharmaceutical Sciences (K.Ha., K.Hi.), and Global Center for Medical Engineering and Informatics (H.M.), Osaka University, Osaka, Japan; PRESTO, Japan Science and Technology Agency, Saitama, Japan (K.T.); and Laboratory of Hepatocyte Regulation, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan (Y.T., K.T., H.M.)
Hiroyuki Mizuguchi
Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences (S.D., T.Y., K.I., Y.T., K.T., H.M.), Laboratory of Applied Environmental Biology, Graduate School of Pharmaceutical Sciences (K.Ha., K.Hi.), and Global Center for Medical Engineering and Informatics (H.M.), Osaka University, Osaka, Japan; PRESTO, Japan Science and Technology Agency, Saitama, Japan (K.T.); and Laboratory of Hepatocyte Regulation, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan (Y.T., K.T., H.M.)
In this issue
Research ArticleArticle
Modeling of CYP2C19 PM Using Genome-Edited hiPSCs
Sayaka Deguchi, Tomoki Yamashita, Keisuke Igai, Kazuo Harada, Yukiko Toba, Kazumasa Hirata, Kazuo Takayama and Hiroyuki Mizuguchi
Drug Metabolism and Disposition June 1, 2019, 47 (6) 632-638; DOI: https://doi.org/10.1124/dmd.119.086322
Research ArticleArticle
Modeling of CYP2C19 PM Using Genome-Edited hiPSCs
Sayaka Deguchi, Tomoki Yamashita, Keisuke Igai, Kazuo Harada, Yukiko Toba, Kazumasa Hirata, Kazuo Takayama and Hiroyuki Mizuguchi
Drug Metabolism and Disposition June 1, 2019, 47 (6) 632-638; DOI: https://doi.org/10.1124/dmd.119.086322
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