Per1 | A circadian factor that forms a heterodimer with Crys to repress Clock/Bmal1 activity | Mitsui et al., 2001 |
Arnt | A cofactor for AhR and HIF-1 that regulates the expression of genes involved in xenobiotic metabolism | Nakabayashi et al., 2013 |
Cyp2a5 | A drug-metabolizing enzyme involved in the metabolism and detoxification of xenobiotics | Lavery et al., 1999; Zhang et al., 2018 |
CYP3A4 | A drug-metabolizing enzyme involved in the metabolism and detoxification of xenobiotics | Takiguchi et al., 2007 |
Cyp3a11 | A drug-metabolizing enzyme involved in the metabolism and detoxification of xenobiotics | Lin et al., 2019a; Tong et al., 2019 |
Cyp7a1 | The rate-limiting enzyme that catalyzes the conversion of cholesterol to bile acids in the liver | Noshiro et al., 2007 |
Fmo5 | A NADPH-dependent flavoenzyme that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics | Chen et al., 2019a |
Mrp2 | An ABC transporter that mediates the efflux of endogenous/exogenous compounds | Yu et al., 2019 |