Abstract
Hamster liver microsomes catalyze the N-hydroxylation of trans-4-acetamidostilbene and its 4'-Cl and 4'-F analogs. Other metabolites which were detected and quantitated were the 4'-OH derivative of trans-4-acetamidostilbene and the glycolamides of the 4'-Cl and 4'-F compounds. The kinetics of metabolism of the acetamidostilbenes were also determined. The apparent KM values of N-hydroxylation of the four substrates were similar, but the maximal velocities showed marked variations. The Vmax for the 4'-Br analog was 16% of that of trans-4-acetamidostilbene, and the rate of N-hydroxylation of the 4'Cl and 4'-F analogs was only 3% of that of the parent compound.
DMD articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
Log in using your username and password
Purchase access
You may purchase access to this article. This will require you to create an account if you don't already have one.