Abstract
After the intravenous injection of 14C-dicumarol, the drug or its metabolite(s) were found to be eliminated in the bile of rats. Over a 4-hr period of collection, 8.35% of the injected radioactivity appeared in the bile, and only 1.02% in the urine. After injection of the 14C-dicumarol into the lumen of the duodenum, radioactivity appeared in the bile, but there was some delay as compared with the results of intravenous administration of the drug. Analysis of the intestinal contents showed the highest radioactivity in the contents of the duodenum, less in the jejunum, and the least in the ileum at the end of the experiment. Pretreatment of rats with sodium phenobarbital resulted in an increase in bile flow and a 3-fold increase in excretion of radioactivity in the bile initiating from 14C-dicumarol. SKF 525-A did not affect the rate of bile flow, but reduced the excretion of radioactivity to one-fourth that of control rats. Sustained choleresis, produced by the infusion of sodium dehydrocholate, had no effect on the excretion of radioactivity in the bile derived from 14C-dicumarol.
Footnotes
- Received July 31, 1972.
- Copyright © 1973 by The American Society for Pharmacology and Experimental Therapeutics
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