%PDF-1.4
%
152 0 obj
<>
endobj
195 0 obj
<>stream
AppendPDF 3.2.1 Solaris SPDF_1092 Jan 21 2004
2007-08-26T19:10:36-07:00
2024-03-28T06:48:48-07:00
2024-03-28T06:48:48-07:00
uuid:9ee815ab-1dd1-11b2-0a00-ffbfedb80000
uuid:278a38c3-1dd2-11b2-0a00-3800e85290ff
application/pdf
endstream
endobj
37 0 obj
<>
endobj
135 0 obj
<>
endobj
104 0 obj
<>
endobj
75 0 obj
<>
endobj
148 0 obj
<>
endobj
57 0 obj
<>
endobj
53 0 obj
<>
endobj
49 0 obj
<>
endobj
45 0 obj
<>
endobj
41 0 obj
<>
endobj
36 0 obj
<>
endobj
35 0 obj
<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/Type/Page>>
endobj
196 0 obj
[199 0 R]
endobj
197 0 obj
<>stream
q
468 0 0 735 0 0 cm
/Im0 Do
Q
BT
/T1_0 1 Tf
9 0 0 9 127.90729 768.99997 Tm
(This article has not been copyedited and formatted. The final version ma\
y differ from this version.)Tj
2.46896 1 Td
(DMD Fast Forward. Published on August 30, 2007 as DOI: 10.1124/dmd.107.0\
17251)Tj
ET
BT
/T1_0 1 Tf
0 -9 9 0 595 392.75554 Tm
( at ASPET Journals on March 28, 2024)Tj
-8.888 0 Td
(dmd.aspetjournals.org)Tj
-7.55399 0 Td
(Downloaded from )Tj
ET
endstream
endobj
34 0 obj
<>stream
JFIF .Handmade Software, Inc. Image Alchemy v1.13
$.' ",#(7),01444'9=82<.342
2!!22222222222222222222222222222222222222222222222222 ?!
} !1AQa"q2#BR$3br
%&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz w !1AQaq"2B #3Rbr
$4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ? ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( (/W6iVQ|3@#*H# ?? 0 Tw ? P ߃ k c G'~ C ?U ? 0 Tw ? P ߃ k c G'~ C ?U ? 0 Tw ? P ߃ k c G'~ C ?U [|Kk
ozuF%`I
I$֠ o | CCS|ķ) MվqF3rʺ7sjWӢ]LҰPI,I$t>|?x?S/C%1 L;G
(
(
(
(
(
(
(
(
(
(
(
(
(
(
vnkc8dbRXN8h3 ס *N C^ ?;
za 51 ס *N C^ ?;
za 51 ס * ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( (kw|GO?/Iv
8W ` :P7|nnNIQ<34G]d,HtR#xTl/̷-kvBN I@9j(WMֻ[Ɨj7+[kWC q=j 0 S\ tM xMs 4 5M '?T?]7 Uu/
k5j&c7ZJX@c@TP?P ' OW-g1ˤ\c9! 'csx;C˺2X0$ ڢ
(
(
(
(
(
(
(
(
(
(
(
(
(
( hO iCHǤE9\PprrDx1@?E PE PSP̺a7$2H+z ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( +ǥ6YH{dK˅a3Ј@q@@P~?O/ +'
( 9_=cSIɼsN2l W^:6=p_o&Zq2\ Av$4y%v bw;U`O@kJ (W>w>|֗hGQ*pRp@:_wep[XP1AH=19 [=RS d($N!"c^>PHcԐo} ( ( ( ( ( ( ( ( ( ( ( ( ( (wY{߾kHW
' FI|7{q7r .y}nv9c2I8
[x37V\[xkX