Article Figures & Data
Additional Files
Data Supplement
Files in this Data Supplement:
- Supplemental Data -
Methods
Supplemental Figure 1 - Uptake of estradiol-17-beta-glucuronide (1% of 3H radiolabeled compound in 1 mu-M) in the mock- / rOATP1B2-MDCK cells
Supplemental Figure 2 - Incubation time-uptake rate curve for LB (10 mu-M) in Mock (●)- / rOATP1B2 (○)- expressing MDCK cells
Supplemental Figure 3 - The inhibitory effect of the DMSO content (%) in the transport medium on the transport of LB (1 mu-M) into MDCK cells
Supplemental Figure 4 - (A) The effect of the BSA content (%) in the rinsing solution on the protein concentration in the cell lysate
Supplemental Figure 5 - The inhibitory effect of the DMSO content (%) in the transport medium (i.e., KHB) on transport of LB (3 mu-M) into isolated rat hepatocytes at 37?C
Supplemental Figure 6 - (A) Incubation time-uptake rate curves for LB (10 mu-M) in isolated rat hepatocytes at 4?C (●) and 37?C (○)
Supplemental Figure 7 - Observed and simulated tissues and plasma concentration?time profiles for LB (A) after IV bolus administration of 1 mg/kg dose of LB and ATV...
Supplemental Figure 8 - Observed and simulated liver concentration?time profiles for LB after IV bolus administration of 1 mg/kg with 5 mg/kg dose of ATV to rats
- Supplemental Data -