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Research ArticleArticle

Metabolite Identification, Reaction Phenotyping and Retrospective Drug-Drug Interaction Predictions of 17-deacetylnorgestimate, the Active Component of the Oral Contraceptive Norgestimate

Deepak Ahire, Sarmistha Sinha, Barry Brock, Ramaswamy Iyer, Sandhya Mandlekar and Murali Subramanian
Drug Metabolism and Disposition March 10, 2017, dmd.116.073940; DOI: https://doi.org/10.1124/dmd.116.073940
Deepak Ahire
Syngene International;
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Sarmistha Sinha
Syngene International;
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Barry Brock
BMS;
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Ramaswamy Iyer
Bristol-Myers Squibb Co.
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Sandhya Mandlekar
BMS;
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Murali Subramanian
Syngene International;
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  • For correspondence: murali.subramanian@syngeneintl.com
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      Supplementary Figure 1 - Disappearance of NGMN in all tested recombinant cytochrome P450s (A) and NG in all the tested recombinant cytochrome P450s (B) and UGTs (C)

      Supplementary Figure 2 - HRMS spectra of NGMN along with structure elucidation of metabolites

      Supplementary Figure 3 - HRMS spectra of NG along with structure elucidation of metabolites

      Supplementary Figure 4 - Reaction phenotyping of NG in rCYPs showing % metabolite formation in respective CYP isoform

      LC-MS Analysis

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Drug Metabolism and Disposition: 46 (5)
Drug Metabolism and Disposition
Vol. 46, Issue 5
1 May 2018
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Research ArticleArticle

Metabolite Identification, Reaction Phenotyping and Retrospective Drug-Drug Interaction Predictions of 17-deacetylnorgestimate, the Active Component of the Oral Contraceptive Norgestimate

Deepak Ahire, Sarmistha Sinha, Barry Brock, Ramaswamy Iyer, Sandhya Mandlekar and Murali Subramanian
Drug Metabolism and Disposition March 10, 2017, dmd.116.073940; DOI: https://doi.org/10.1124/dmd.116.073940

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Research ArticleArticle

Metabolite Identification, Reaction Phenotyping and Retrospective Drug-Drug Interaction Predictions of 17-deacetylnorgestimate, the Active Component of the Oral Contraceptive Norgestimate

Deepak Ahire, Sarmistha Sinha, Barry Brock, Ramaswamy Iyer, Sandhya Mandlekar and Murali Subramanian
Drug Metabolism and Disposition March 10, 2017, dmd.116.073940; DOI: https://doi.org/10.1124/dmd.116.073940
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