Article Figures & Data
Additional Files
- Supplemental Data -
Supplementary Figure S1: A three compartment model representing the maternal (M),
placental (P), and fetal (F) compartments: 0- irreversible elimination. The remaining
abbreviations are as in Figure 1. For simplicity, excretion of drugs from fetus into the
amniotic fluid was assumed to be negligible.
Supplementary Figure S2: Changes in fetal renal clearance (fCLR) or fetal amniotic
fluid swallowing rate (fCLreabsorp) affected drug concentrations in fetal plasma and
amniotic fluid differently
Supplementary Figure S3: In this schematic, Xc and Xp denotes the amount of drug in
the central compartment and the peripheral compartments, respectively; k10 is the central
compartment elimination rate constant, whereas k12, and k21 are the inter-compartmental
distribution rate constants.
Supplementary Table 1
Supplementary Table 2
- Supplemental Data -