Article Figures & Data
Additional Files
Data Supplement
- Supplemental Data -
Supplemental Text
Supplemental Table 1 - Donor characteristics of hepatocyte lots
Supplemental Table 2 -Sensitivity analysis of the impact of MRP3 on intracellular accumulation of pitavastatin
Supplemental Table 3 - Physicochemical properties and pharmacokinetic parameters of rifampicin and cyclosporine reported in the literature that were utilized for predicting AUCR values resulting from hepatic uptake inhibition of pitavastatin
References for Tables
Supplemental Figure 1- Uptake of estrone-3-sulfate (A), CCK-8 (B), and taurocholic acid (C) in HEK293 cells transfected with OATP1B1, OATP1B3, and NTCP, respectively
Supplemental Figure 2 - Uptake of estrone-3-sulfate, CCK-8, and taurocholic acid in suspension hepatocytes (A-D lot HUP1001, E-H lot HUM4122D
Supplemental Figure 3 - Uptake of estrone-3-sulfate, CCK-8, and taurocholic acid in SCHH (A-C lot HU1651, D-G lot HUM4122D)
Supplemental Figure 4 - Individual predicted concentrations versus observed concentrations for pitavastatin in media (A1- C1) and in cells (A2 -C2) at 4°C
Supplemental Figure 5 - Individual predicted concentrations versus observed concentrations for pitavastatin in media (A1-D1) and in cells (A2-D2) at 37°C
- Supplemental Data -