Article Figures & Data
Additional Files
Data Supplement
- Supplemental Data -
Supplemental Figure 1 - Selective metabolites of siponimod by CYP2C9 as compared with human liver microsomes (HLM) and CYP3A4
Supplemental Figure 2 - Schematic presentation of the synthesis of the M1, M2 and M8
Supplemental Figure 3 - MS and NMR data of the authentic reference compounds: Metabolite M1 (A), Metabolite M2 (B), Metabolite M3 (C), Metabolite M4a (D), Metabolite M4b (E), Metabolite M4c (F), Metabolite M4d (G), Metabolite M5 (H), Metabolite M6 (I), Metabolite M7 (K), Metabolite M17
Supplemental Table 1 - Siponimod and related compounds in mouse plasma following a single oral dose of 25 mg/kg [14C]siponimod referring to base-, Not detected or below lower limit of quantitation
Supplemental Methods
- Supplemental Data -