Research ArticleArticle
Considerations from the IQ Induction Working Group in Response to Drug-Drug Interaction Guidances from Regulatory Agencies: Focus on CYP3A4 mRNA in vitro response thresholds, variability, and clinical relevance
Jane R Kenny, Diane Ramsden, David B Buckley, Shannon Dallas, Conrad Fung, Michael Mohutsky, Heidi J Einolf, Liangfu Chen, Joshua G Dekeyser, Maria Fitzgerald, Theunis C Goosen, Y Amy Siu, Robert L Walsky, George Zhang, Donald Tweedie and Niresh Hariparsad
Drug Metabolism and Disposition June 29, 2018, dmd.118.081927; DOI: https://doi.org/10.1124/dmd.118.081927
Jane R Kenny
1 Genentech Inc;
Diane Ramsden
2 Boehringer Ingelheim;
David B Buckley
3 Sekisui-XenoTech LLC;
Shannon Dallas
4 Janssen R&D;
Conrad Fung
5 Vertex Pharmaceuticals;
Michael Mohutsky
6 Eli Lilly and Company;
Heidi J Einolf
7 Novartis;
Liangfu Chen
8 GlaxoSmithKline;
Joshua G Dekeyser
9 Amgen Inc;
Maria Fitzgerald
10 Sanofi;
Theunis C Goosen
11 Pfizer Global Research and Development;
Y Amy Siu
12 Eisai;
Robert L Walsky
13 Serono R&D Institute, Inc.,;
George Zhang
14 Corning Life Sciences;
Donald Tweedie
15 Merck & Co., Inc
Niresh Hariparsad
5 Vertex Pharmaceuticals;
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Research ArticleArticle
Considerations from the IQ Induction Working Group in Response to Drug-Drug Interaction Guidances from Regulatory Agencies: Focus on CYP3A4 mRNA in vitro response thresholds, variability, and clinical relevance
Jane R Kenny, Diane Ramsden, David B Buckley, Shannon Dallas, Conrad Fung, Michael Mohutsky, Heidi J Einolf, Liangfu Chen, Joshua G Dekeyser, Maria Fitzgerald, Theunis C Goosen, Y Amy Siu, Robert L Walsky, George Zhang, Donald Tweedie and Niresh Hariparsad
Drug Metabolism and Disposition June 29, 2018, dmd.118.081927; DOI: https://doi.org/10.1124/dmd.118.081927
Research ArticleArticle
Considerations from the IQ Induction Working Group in Response to Drug-Drug Interaction Guidances from Regulatory Agencies: Focus on CYP3A4 mRNA in vitro response thresholds, variability, and clinical relevance
Jane R Kenny, Diane Ramsden, David B Buckley, Shannon Dallas, Conrad Fung, Michael Mohutsky, Heidi J Einolf, Liangfu Chen, Joshua G Dekeyser, Maria Fitzgerald, Theunis C Goosen, Y Amy Siu, Robert L Walsky, George Zhang, Donald Tweedie and Niresh Hariparsad
Drug Metabolism and Disposition June 29, 2018, dmd.118.081927; DOI: https://doi.org/10.1124/dmd.118.081927
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