Article Figures & Data
Additional Files
Data Supplement
- Supplemental Data -
Supplemental Data
Supplemental Figure 1 - Structures of six ester prodrugs and their hydrolysis into the active form by esterase
Supplemental Figure 2 - Marker expression in hiPSCs, differentiated DEs, and HGs
Supplemental Figure 3 - Gene expression levels of intestinal markers in adult small intestine, fetal small intestine, hiPSCs, adn hiPSC-IECs
Supplemental Figure 4 - Schematic diagram illustrating behavior of a prodrug around intestinal epithelial cells
Supplemental Table 1 - Generic name of prodrugs A, B, C, D, E, and F and the active form
Supplemental Table 2 - Primer information in real-time RT-PCS using a TaqMan® Universal PCR Master Mix
Supplemental Table 3 - Primer information in real-time RT-PCR using a One Step SYBR® PrimeScriptTM PLUS RT-PCR Kit
Supplemental Table 4 - Conditions for LC-MS/MS analysis
Supplemental Table 5 - Hydrolysis activity in hiPSC-IEC monolayers and pharmacokinetic parameters in rats of six ester prodrugs
Supplemental Table 6 - Prediction of human Fa of values 14 drugs from their Papp values across hiPSC-IEC monolayers
References
- Supplemental Data -