Research ArticleArticle
NADPH-Independent Inactivation of CYP2B6 and NADPH-dependent Inactivation of CYP3A4/5 by Pyrrolobenzodiazepine Dimer (PBD) and Potential Implication for Assessing Covalent Modulators for Time-dependent Inhibition
Mika Kosaka, Donglu Zhang, Simon Wong and Zhengyin Yan
Drug Metabolism and Disposition June 1, 2020, dmd.120.090878; DOI: https://doi.org/10.1124/dmd.120.090878
Mika Kosaka
1 MyoKardia;
Donglu Zhang
2 Genentech;
Simon Wong
3 Pilant Therapeutics;
Zhengyin Yan
4 Genentech INC
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Research ArticleArticle
NADPH-Independent Inactivation of CYP2B6 and NADPH-dependent Inactivation of CYP3A4/5 by Pyrrolobenzodiazepine Dimer (PBD) and Potential Implication for Assessing Covalent Modulators for Time-dependent Inhibition
Mika Kosaka, Donglu Zhang, Simon Wong and Zhengyin Yan
Drug Metabolism and Disposition June 1, 2020, dmd.120.090878; DOI: https://doi.org/10.1124/dmd.120.090878
Research ArticleArticle
NADPH-Independent Inactivation of CYP2B6 and NADPH-dependent Inactivation of CYP3A4/5 by Pyrrolobenzodiazepine Dimer (PBD) and Potential Implication for Assessing Covalent Modulators for Time-dependent Inhibition
Mika Kosaka, Donglu Zhang, Simon Wong and Zhengyin Yan
Drug Metabolism and Disposition June 1, 2020, dmd.120.090878; DOI: https://doi.org/10.1124/dmd.120.090878
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