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Identification of 19-(S/R)Hydroxyeicosatetraenoic Acid as the First Endogenous Non-Competitive Inhibitor of Cytochrome P450 CYP1B1 with Enantioselective Activity
Sherif M. Shoieb, Ahmed A. El-Sherbeni and Ayman O.S. El-Kadi

Drug Metabolism and Disposition November 12, 2018, dmd.118.084657; DOI: https://doi.org/10.1124/dmd.118.084657
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Prediction of human distribution volumes of compounds in various elimination phases using physiologically based pharmacokinetic modeling and experimental pharmacokinetics in animals
Hidetoshi Shimizu, Kosuke Yoshida, Tomohisa Nakada, Koki Kojima, Akihito Ogasawara, Yoshinobu Nakamaru and Hiroshi Yamazaki

Drug Metabolism and Disposition November 12, 2018, dmd.118.083642; DOI: https://doi.org/10.1124/dmd.118.083642
Open Access
Identification and Quantification of Novel Major Metabolites of the Steroidal Aromatase Inhibitor, Exemestane
Shaman Luo, Gang Chen, Cristina I. Truica, Cynthia C. Baird, Zuping Xia and Philip Lazarus

Drug Metabolism and Disposition December 2018, 46 (12) 1867-1878; DOI: https://doi.org/10.1124/dmd.118.081166
Open Access
Calcitriol and Calcipotriol Modulate Transport Activity of ABC Transporters and Exhibit Selective Cytotoxicity in MRP1-overexpressing Cells
Kee W. Tan, Angelina Sampson, Bremansu Osa-Andrews and Surtaj H. Iram

Drug Metabolism and Disposition December 2018, 46 (12) 1856-1866; DOI: https://doi.org/10.1124/dmd.118.081612
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Regional Differences in Human Intestinal Drug Metabolism
Raditya Iswandana, Marina I. Irianti, Dorenda Oosterhuis, Hendrik S. Hofker, Marjolijn T. Merema, Marina H. de Jager, Henricus A. M. Mutsaers and Peter Olinga

Drug Metabolism and Disposition December 2018, 46 (12) 1879-1885; DOI: https://doi.org/10.1124/dmd.118.083428
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Polymorphisms of the Multidrug Pump ABCG2: A Systematic Review of Their Effect on Protein Expression, Function, and Drug Pharmacokinetics
Niall Heyes, Parth Kapoor and Ian D. Kerr

Drug Metabolism and Disposition December 2018, 46 (12) 1886-1899; DOI: https://doi.org/10.1124/dmd.118.083030
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Quantitation of lysosomal trapping of basic lipophilic compounds using in vitro assays and in silico predictions based on the determination of the full pH profile of the endo-/lysosomal system in rat hepatocytes
Maximilian V Schmitt, Philip Lienau, Gert Fricker and Andreas Reichel

Drug Metabolism and Disposition November 8, 2018, dmd.118.084541; DOI: https://doi.org/10.1124/dmd.118.084541
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Berberine Directly Impacts the Gut Microbiota to Promote Intestinal Farnesoid X Receptor Activation
Yuan Tian, Jingwei Cai, Wei Gui, Robert G. Nichols, Imhoi Koo, Jingtao Zhang, Mallappa Anitha and Andrew D. Patterson

Drug Metabolism and Disposition November 8, 2018, dmd.118.083691; DOI: https://doi.org/10.1124/dmd.118.083691
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6-Chloro-5-[4-(1-Hydroxycyclobutyl)Phenyl]-1H-Indole-3-Carboxylic Acid is a Highly Selective Substrate for Glucuronidation by UGT1A1, Relative to β-Estradiol
Kimberly Lapham, Jian Lin, Jonathan Novak, Christine Orozco, Mark Niosi, Li Di, Theunis C. Goosen, Sangwoo Ryu, Keith Riccardi, Heather Eng, Kimberly O. Cameron and Amit S. Kalgutkar

Drug Metabolism and Disposition December 2018, 46 (12) 1836-1846; DOI: https://doi.org/10.1124/dmd.118.083709
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Metabolism of c-Met Kinase Inhibitors Containing Quinoline by Aldehyde Oxidase, Electron Donating, and Steric Hindrance Effect
Jiang Wei Zhang, Wen Xiao, Zhen Ting Gao, Zheng Tian Yu and Ji Yue (Jeff) Zhang

Drug Metabolism and Disposition December 2018, 46 (12) 1847-1855; DOI: https://doi.org/10.1124/dmd.118.081919

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