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Alternative Splicing in the Nuclear Receptor Superfamily Redirects Human Metabolic Homeostasis.
Andrew J. Annalora, Craig B. Marcus and Patrick L. Iversen

Drug Metabolism and Disposition January 24, 2020, dmd.119.089102; DOI: https://doi.org/10.1124/dmd.119.089102
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Effects of Pregnancy on the Pharmacokinetics of Metformin
Michael Z. Liao, Shannon K. Flood Nichols, Mahmoud Ahmed, Shannon Clark, Gary D. Hankins, Steve Caritis, Raman Venkataramanan, David Haas, Sara K. Quinney, Laura S. Haneline, Alan T. Tita, Tracy Manuck, Joanne Wang, Kenneth E. Thummel, Linda Morris Brown, Zhaoxia Ren, Thomas R Easterling and Mary F. Hebert

Drug Metabolism and Disposition January 24, 2020, dmd.119.088435; DOI: https://doi.org/10.1124/dmd.119.088435
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Differential role of LXRα and LXRβ in the regulation of UDP-glucuronosyltransferase 1A1 in humanized UGT1 mice
Eva Hansmann, Elvira Mennillo, Emiko Yoda, Melanie Verreault, Olivier Barbier, Shu-Juan Chen and Robert Howard Tukey

Drug Metabolism and Disposition January 24, 2020, dmd.119.090068; DOI: https://doi.org/10.1124/dmd.119.090068
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Metabolism and Disposition of Ataluren following Oral Administration to Mice, Rats, Dogs, and Humans
Ronald Kong, Jiyuan Ma, Seongwoo Hwang, Elizabeth Goodwin, Valerie Northcutt, John Babiak, Neil Almstead and Joseph McIntosh

Drug Metabolism and Disposition January 24, 2020, dmd.119.089391; DOI: https://doi.org/10.1124/dmd.119.089391
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Quantitative Proteomics of Clinically Relevant Drug-Metabolizing Enzymes and Drug Transporters and Their Inter-correlations in the Human Small Intestine
Narciso Couto, Zubida Al-Majdoub, Stephanie Gibson, Pamela Davies, Brahim Achour, Matthew D Harwood, Gordon Carlson, Jill Barber, Amin Rostami-Hodjegan and Geoffrey Warhurst

Drug Metabolism and Disposition January 20, 2020, dmd.119.089656; DOI: https://doi.org/10.1124/dmd.119.089656
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Abundant Expression of OCT2, MATE1, OAT1, OAT3, PEPT2, BCRP, MDR1, and xCT Transporters in Blood-Arachnoid Barrier of Pig and Polarized Localizations at CSF- and Blood-Facing Plasma Membranes
Yasuo Uchida, Ryohei Goto, Hina Takeuchi, Magdalena Łuczak, Takuya Usui, Masanori Tachikawa and Tetsuya Terasaki

Drug Metabolism and Disposition February 2020, 48 (2) 135-145; DOI: https://doi.org/10.1124/dmd.119.089516
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Carbonyl reductase 1 plays a significant role in converting doxorubicin to cardiotoxic doxorubicinol in mouse liver, but the majority of the doxorubicinol-forming activity remains unidentified
Daniel H Breysse, Ryan M Boone, Cameron M Long, Miranda E Merrill, Christopher M Schaupp, Collin C White, Terrance J Kavanagh, Edward E Schmidt and Gary Frederic Merrill

Drug Metabolism and Disposition January 18, 2020, dmd.119.089326; DOI: https://doi.org/10.1124/dmd.119.089326
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Piperine Is a Mechanism-Based Inactivator of CYP3A
Tiantian Cui, Qian Wang, Xiaoxiao Tian, Kehan Zhang, Ying Peng and Jiang Zheng

Drug Metabolism and Disposition February 2020, 48 (2) 123-134; DOI: https://doi.org/10.1124/dmd.119.088955
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Mechanistic Modeling of the Hepatic Disposition of Estradiol-17β-Glucuronide in Sandwich-Cultured Human Hepatocytes
Katsuaki Ito, Noora Sjöstedt and Kim L.R. Brouwer

Drug Metabolism and Disposition February 2020, 48 (2) 116-122; DOI: https://doi.org/10.1124/dmd.119.088898
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N-Oxygenation of Oxycodone and Retro-reduction of Oxycodone N-Oxide
John R. Cashman, Mark Gohdes, Annelies de Kater and Grant Schoenhard

Drug Metabolism and Disposition February 2020, 48 (2) 106-115; DOI: https://doi.org/10.1124/dmd.119.089300

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