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Stereospecific Metabolism of R- and S-Warfarin by Human Hepatic Cytosolic Reductases
Dustyn A Barnette, Bryce Johnson, Dakota L Pouncey, Robert Nshimiyimana, Linda Desrochers, Thomas E Goodwin and Grover Paul Miller

Drug Metabolism and Disposition June 23, 2017, dmd.117.075929; DOI: https://doi.org/10.1124/dmd.117.075929
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Identification of flavin-containing monooxygenase 5 (FMO5) as a regulator of glucose homeostasis and a potential sensor of gut bacteria
Flora Scott, Sandra G Gonzalez Malagon, Brett A O'Brien, Diede Fennema, Sunil Veeravalli, Clarissa R Coveney, Ian R Phillips and Elizabeth A. Shephard

Drug Metabolism and Disposition June 23, 2017, dmd.117.076612; DOI: https://doi.org/10.1124/dmd.117.076612
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Considerations from the IQ Induction Working Group in Response to Drug-Drug Interaction Guidances from Regulatory Agencies: Focus on Down-regulation, CYP2C Induction and CYP2B6 Positive Control
Niresh Hariparsad, Diane Ramsden, Jairam Palamanda, Joshua G Dekeyser, Odette A Fahmi, Jane R Kenny, Heidi Einolf, Michael Mohutsky, Magalie Pardon, Amy Y Siu, Liangfu Chen, Michael Sinz, Barry Jones, Robert Walsky, Shannon Dallas, Suresh K Balani, George Zhang, David Buckley and Donald Tweedie

Drug Metabolism and Disposition June 23, 2017, dmd.116.074567; DOI: https://doi.org/10.1124/dmd.116.074567
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RNA Sequencing Reveals Age and Species Differences of Constitutive Androstane Receptor–Targeted Drug-Processing Genes in the Liver
Sunny Lihua Cheng, Theo K. Bammler and Julia Yue Cui

Drug Metabolism and Disposition July 2017, 45 (7) 867-882; DOI: https://doi.org/10.1124/dmd.117.075135
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Age-dependent protein abundance of cytosolic alcohol and aldehyde dehydrogenases in human liver
Deepak Kumar Bhatt, Andrea Gaedigk, Robin E. Pearce, J. Steven Leeder and Bhagwat Prasad

Drug Metabolism and Disposition June 12, 2017, dmd.117.076463; DOI: https://doi.org/10.1124/dmd.117.076463
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Inhibition of the all-trans Retinoic Acid (atRA) Hydroxylases CYP26A1 and CYP26B1 Results in Dynamic, Tissue-Specific Changes in Endogenous atRA Signaling
Faith Stevison, Cathryn Hogarth, Sasmita Tripathy, Travis Kent and Nina Isoherranen

Drug Metabolism and Disposition July 2017, 45 (7) 846-854; DOI: https://doi.org/10.1124/dmd.117.075341
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Penetration Route of the Selective Glucocorticoid Receptor Agonist SA22465 and Betamethasone into Rabbit Meibomian Gland Based on Pharmacokinetics and Autoradiography
Nagayoshi Asano, Kenji Ueda and Kouichi Kawazu

Drug Metabolism and Disposition July 2017, 45 (7) 826-833; DOI: https://doi.org/10.1124/dmd.117.075473
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Modeling Combined Immunosuppressive and Anti-inflammatory Effects of Dexamethasone and Naproxen in Rats Predicts the Steroid-Sparing Potential of Naproxen
Xiaonan Li, Debra C. DuBois, Dawei Song, Richard R. Almon, William J. Jusko and Xijing Chen

Drug Metabolism and Disposition July 2017, 45 (7) 834-845; DOI: https://doi.org/10.1124/dmd.117.075614
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Integrated Assessment of Diclofenac Biotransformation, Pharmacokinetics, and Omics-Based Toxicity in a Three-Dimensional Human Liver-Immunocompetent Coculture System
Ujjal Sarkar, Kodihalli C. Ravindra, Emma Large, Carissa L. Young, Dinelia Rivera-Burgos, Jiajie Yu, Murat Cirit, David J. Hughes, John S. Wishnok, Douglas A. Lauffenburger, Linda G. Griffith and Steven R. Tannenbaum

Drug Metabolism and Disposition July 2017, 45 (7) 855-866; DOI: https://doi.org/10.1124/dmd.116.074005
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Characterization and Interspecies Scaling of rhTNF-α Pharmacokinetics with Minimal Physiologically Based Pharmacokinetic Models
Xi Chen, Debra C. DuBois, Richard R. Almon and William J. Jusko

Drug Metabolism and Disposition July 2017, 45 (7) 798-806; DOI: https://doi.org/10.1124/dmd.116.074799

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