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Do In Vitro Assays Predict Drug Candidate Idiosyncratic Drug-Induced Liver Injury Risk?
J. Gerry Kenna and Jack Uetrecht

Drug Metabolism and Disposition July 18, 2018, dmd.118.082719; DOI: https://doi.org/10.1124/dmd.118.082719
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Metabolism of anethole dithiolethione by rat and human liver microsomes: formation of various products deriving from its O-demethylation and S-oxidation. Involvement of cytochromes P450 and flavin monooxygenases in these pathways.
Martin Dulac, Amor Sassi, Citra Nagarathinan, Marie-Odile Christen, Patrick M Dansette, Daniel Mansuy and Jean-Luc Boucher

Drug Metabolism and Disposition July 17, 2018, dmd.118.082545; DOI: https://doi.org/10.1124/dmd.118.082545
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PBDEs Altered Gut Microbiome and Bile Acid Homeostasis in Male C57BL/6 Mice
Cindy Yanfei Li, Joseph L. Dempsey, Dongfang Wang, SooWan Lee, Kris M. Weigel, Qiang Fei, Deepak Kumar Bhatt, Bhagwat Prasad, Daniel Raftery, Haiwei Gu and Julia Yue Cui

Drug Metabolism and Disposition August 2018, 46 (8) 1226-1240; DOI: https://doi.org/10.1124/dmd.118.081547
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The Drug-Drug Interaction Potential of Antiviral Agents for the Treatment of Chronic Hepatitis C Infection
Kimberly L. Garrison, Polina German, Erik Mogalian and Anita Mathias

Drug Metabolism and Disposition August 2018, 46 (8) 1212-1225; DOI: https://doi.org/10.1124/dmd.117.079038
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Consequences of Phenytoin Exposure on Hepatic Cytochrome P450 Expression during Postnatal Liver Maturation in Mice
Stephanie C. Piekos, Liming Chen, Pengcheng Wang, Jian Shi, Sharon Yaqoob, Hao-Jie Zhu, Xiaochao Ma and Xiao-bo Zhong

Drug Metabolism and Disposition August 2018, 46 (8) 1241-1250; DOI: https://doi.org/10.1124/dmd.118.080861
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Application of Physiologically Based Pharmacokinetic Modeling in Understanding Bosutinib Drug-Drug Interactions: Importance of Intestinal P-Glycoprotein
Shinji Yamazaki, Cho-Ming Loi, Emi Kimoto, Chester Costales and Manthena V. Varma

Drug Metabolism and Disposition August 2018, 46 (8) 1200-1211; DOI: https://doi.org/10.1124/dmd.118.080424
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Cryopreserved human intestinal mucosal epithelium: a novel in vitro experimental system for the evaluation of enteric drug metabolism, P450 induction, and enterotoxicity
Albert P. Li, Novera Alam, kirsten Amaral, Ming-Chih David Ho, Carol Loretz, Walter Mitchell and Qian Yang

Drug Metabolism and Disposition July 13, 2018, dmd.118.082875; DOI: https://doi.org/10.1124/dmd.118.082875
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Biotransformation of ilaprazole in human liver microsomes and human: role of CYP3A4 in ilaprazole clearance and drug-drug interaction
Jie Pu, Fen Wang, Wei Tang and Mingshe Zhu

Drug Metabolism and Disposition July 12, 2018, dmd.118.081570; DOI: https://doi.org/10.1124/dmd.118.081570
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Three Faces of Mercaptopurine Cytotoxicity In Vitro: Methylation, Nucleotide Homeostasis, and Deoxythioguanosine in DNA
Sally A. Coulthard, Sarah McGarrity, Kalvin Sahota, Philip Berry and Chris P. F. Redfern

Drug Metabolism and Disposition August 2018, 46 (8) 1191-1199; DOI: https://doi.org/10.1124/dmd.118.081844
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Comparison of Antifungal Azole Interactions with Adult Cytochrome P450 3A4 vs. Neonatal Cytochrome P450 3A7
Malika P. Godamudunage, Anne M. Grech and Emily E Scott

Drug Metabolism and Disposition July 10, 2018, dmd.118.082032; DOI: https://doi.org/10.1124/dmd.118.082032

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