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Interindividual Variation in CYP3A Activity Influences Lapatinib Bioactivation
Jennifer E. Bissada, Vivian Truong, Arsany A. Abouda, Kahari J. Wines, Rachel D. Crouch and Klarissa D. Jackson

Drug Metabolism and Disposition November 2019, 47 (11) 1257-1269; DOI: https://doi.org/10.1124/dmd.119.088823
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Metabolism of Strained Rings: Glutathione S-transferase–Catalyzed Formation of a Glutathione-Conjugated Spiro-azetidine without Prior Bioactivation
Xue-Qing Li, Gunnar Grönberg, Eva-Henriette Bangur, Martin A. Hayes, Neal Castagnoli and Lars Weidolf

Drug Metabolism and Disposition November 2019, 47 (11) 1247-1256; DOI: https://doi.org/10.1124/dmd.119.088658
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Elucidation of N¹-methyladenosine as a Potential Surrogate Biomarker for Drug Interaction Studies Involving Renal Organic Cation Transporters
Takeshi Miyake, Tadahaya Mizuno, Issey Takehara, Tatsuki Mochizuki, Miyuki Kimura, Shunji Matsuki, Shin Irie, Nobuaki Watanabe, Yukio Kato, Ichiro Ieiri, Kazuya Maeda, Osamu Ando and Hiroyuki Kusuhara

Drug Metabolism and Disposition November 2019, 47 (11) 1270-1280; DOI: https://doi.org/10.1124/dmd.119.087262
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Kinetic Modeling of Steady-State Situations in Cytochrome P450 Enzyme Reactions
F. Peter Guengerich

Drug Metabolism and Disposition November 2019, 47 (11) 1232-1239; DOI: https://doi.org/10.1124/dmd.119.088732
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Impact of Different Selectivity between Soluble and Membrane-bound Forms of Carcinoembryonic Antigen (CEA) on the Target-mediated Disposition of Anti-CEA Monoclonal Antibodies
Junko Iwano, Daisuke Shinmi, Kazuhiro Masuda, Takashi Murakami and Junichi Enokizono

Drug Metabolism and Disposition November 2019, 47 (11) 1240-1246; DOI: https://doi.org/10.1124/dmd.119.088179
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Toxicokinetic interaction between hepatic disposition and pulmonary bioactivation of inhaled naphthalene studied using Cyp2abfgs-null and CYP2A13/2F1-humanized mice with deficient hepatic cytochrome P450 activity
Nataliia Kovalchuk, Qing-Yu Zhang, Jacklyn Kelty, Laura S Van Winkle and Xinxin Ding

Drug Metabolism and Disposition October 8, 2019, dmd.119.088930; DOI: https://doi.org/10.1124/dmd.119.088930
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Organic anion transporting polypeptide (OATP) genes are not induced by the pregnane X receptor (PXR) activator rifampin: studies in hepatocytes in vitro and in monkeys in vivo
Congrong Niu, Yujin Wang, Xiaofeng Zhao, Sam Tep, Eisuke Murakami, Raju Subramanian, Bill Smith and Yurong Lai

Drug Metabolism and Disposition October 3, 2019, dmd.119.088922; DOI: https://doi.org/10.1124/dmd.119.088922
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The role of L- and D-menthol in the glucuronidation and detoxification of the major lung carcinogen, NNAL
Shannon Kozlovich, Gang Chen, Christy JW Watson, William J Blot and Philip Lazarus

Drug Metabolism and Disposition October 2, 2019, dmd.119.088351; DOI: https://doi.org/10.1124/dmd.119.088351
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An Accurate In Vitro Prediction of Human VDss Based on the ØIE-TOZER Equation and Primary Physicochemical Descriptors. 3. Analysis and Assessment of Predictivity on a Large Dataset.
Giuliano Berellini and Franco Lombardo

Drug Metabolism and Disposition October 2, 2019, dmd.119.088914; DOI: https://doi.org/10.1124/dmd.119.088914
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Ginsenoside Rc is a new selective UGT1A9 inhibitor in human liver microsomes and recombinant human UGT isoforms
Hyunyoung Lee, Jae-Kyung Heo, Ga-Hyun Lee, So-Young Park, Su Nyeoung Jang, Hyun-Ji Kim, Mi Jeong Kwon, Im-Sook Song and Kwang-Hyeon Liu

Drug Metabolism and Disposition October 2, 2019, dmd.119.087965; DOI: https://doi.org/10.1124/dmd.119.087965

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