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Meeting the Challenge of Predicting Hepatic Clearance of Compounds Slowly Metabolized by Cytochrome P450 Using a Novel Hepatocyte Model, HepatoPac
Tom S. Chan, Hongbin Yu, Amanda Moore, Salman R. Khetani and Donald Tweedie

Drug Metabolism and Disposition January 2019, 47 (1) 58-66; DOI: https://doi.org/10.1124/dmd.113.053397fullarticlecorrection
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A Novel Pathogenic UGT1A1 Variant in a Sudanese Child with Type 1 Crigler-Najjar Syndrome
Walaa Elfar, Erkka Järvinen, Weizhen Ji, Johanna Mosorin, Annalisa G. Sega, Alina C. Iuga, Steven J. Lobritto, Monica Konstantino, Albert Chan, Moshe Finel and Saquib A. Lakhani

Drug Metabolism and Disposition January 2019, 47 (1) 45-48; DOI: https://doi.org/10.1124/dmd.118.084368
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Quantitation of Lysosomal Trapping of Basic Lipophilic Compounds Using In Vitro Assays and In Silico Predictions Based on the Determination of the Full pH Profile of the Endo-/Lysosomal System in Rat Hepatocytes
Maximilian V. Schmitt, Philip Lienau, Gert Fricker and Andreas Reichel

Drug Metabolism and Disposition January 2019, 47 (1) 49-57; DOI: https://doi.org/10.1124/dmd.118.084541
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Quantitative Analysis of UDP-Glucuronosyltransferase Ugt1a and Ugt2b mRNA Expression in the Rat Liver and Small Intestine: Sex and Strain Differences
Takaya Kutsukake, Yoichi Furukawa, Kyoko Ondo, Saki Gotoh, Tatsuki Fukami and Miki Nakajima

Drug Metabolism and Disposition January 2019, 47 (1) 38-44; DOI: https://doi.org/10.1124/dmd.118.083287
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Evaluation of Carbazeran 4-Oxidation and O⁶-Benzylguanine 8-Oxidation as Catalytic Markers of Human Aldehyde Oxidase: Impact of Cytosolic Contamination of Liver Microsomes
Jiarong Xie, Nur Fazilah Saburulla, Shiyan Chen, Siew Ying Wong, Ze Ping Yap, Linghua Harris Zhang and Aik Jiang Lau

Drug Metabolism and Disposition January 2019, 47 (1) 26-37; DOI: https://doi.org/10.1124/dmd.118.082099
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Characterization of the In Vitro Inhibitory Potential of the Oligonucleotide Imetelstat on Human Cytochrome P450 Enzymes with Predictions of In Vivo Drug-Drug Interactions
Faraz Kazmi, Carlo Sensenhauser and Tony Greway

Drug Metabolism and Disposition January 2019, 47 (1) 9-14; DOI: https://doi.org/10.1124/dmd.118.084103
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Oral Coadministration of Fluconazole with Tramadol Markedly Increases Plasma and Urine Concentrations of Tramadol and the O-Desmethyltramadol Metabolite in Healthy Dogs
Tania E. Perez Jimenez, Butch Kukanich, Hyun Joo, Katrina L. Mealey, Tamara L. Grubb, Stephen A. Greene and Michael H. Court

Drug Metabolism and Disposition January 2019, 47 (1) 15-25; DOI: https://doi.org/10.1124/dmd.118.083444
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Mechanistic In Vitro Studies Indicate that the Clinical Drug-Drug Interaction between Telithromycin and Simvastatin Acid Is Driven by Time-Dependent Inhibition of CYP3A4 with Minimal Effect on OATP1B1
Robert Elsby, Victoria Hare, Hannah Neal, Samuel Outteridge, Catherine Pearson, Katie Plant, Rachel Upcott Gill, Philip Butler and Robert J. Riley

Drug Metabolism and Disposition January 2019, 47 (1) 1-8; DOI: https://doi.org/10.1124/dmd.118.083832
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Toward a Combinatorial Approach for the Prediction of IgG Half-Life and Clearance
Dennis R. Goulet, Michael J. Watson, Susan H. Tam, Adam Zwolak, Mark L. Chiu, William M. Atkins and Abhinav Nath

Drug Metabolism and Disposition December 2018, 46 (12) 1900-1907; DOI: https://doi.org/10.1124/dmd.118.081893
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Regional Differences in Human Intestinal Drug Metabolism
Raditya Iswandana, Marina I. Irianti, Dorenda Oosterhuis, Hendrik S. Hofker, Marjolijn T. Merema, Marina H. de Jager, Henricus A. M. Mutsaers and Peter Olinga

Drug Metabolism and Disposition December 2018, 46 (12) 1879-1885; DOI: https://doi.org/10.1124/dmd.118.083428

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