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Drug Metabolism & Disposition

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Latest Articles

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    Development and Validation of a Higher-Throughput Cytochrome P450 Inhibition Assay with the Novel Cofactor-Supplemented Permeabilized Cryopreserved Human Hepatocytes (MetMax Human Hepatocytes)
    Veera Raghava Choudary Palacharla, Prathyusha Chunduru, Devender Reddy Ajjala, Gopinadh Bhyrapuneni, Ramakrishna Nirogi and Albert P. Li
    Drug Metabolism and Disposition October 2019, 47 (10) 1032-1039; DOI: https://doi.org/10.1124/dmd.119.088237
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    Synthesis and Characterization of Bodipy-FL-Cyclosporine A as a Substrate for Multidrug Resistance-Linked P-Glycoprotein (ABCB1)
    Andaleeb Sajid, Natarajan Raju, Sabrina Lusvarghi, Shahrooz Vahedi, Rolf E. Swenson and Suresh V. Ambudkar
    Drug Metabolism and Disposition October 2019, 47 (10) 1013-1023; DOI: https://doi.org/10.1124/dmd.119.087734
  • Open Access
    Canine Albumin Polymorphisms and Their Impact on Drug Plasma Protein Binding
    Ana P. Costa, Michael H. Court, Neal S. Burke, Zhaohui Zhu, Katrina L. Mealey and Nicolas F. Villarino
    Drug Metabolism and Disposition October 2019, 47 (10) 1024-1031; DOI: https://doi.org/10.1124/dmd.119.087304
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    The Enhancement of Subcutaneous First-Pass Metabolism Causes Nonlinear Pharmacokinetics of TAK-448 after a Single Subcutaneous Administration to Rats
    Yuu Moriya, Akifumi Kogame, Yoshihiko Tagawa, Akio Morohashi, Takahiro Kondo, Satoru Asahi and Leslie Z. Benet
    Drug Metabolism and Disposition September 2019, 47 (9) 1004-1012; DOI: https://doi.org/10.1124/dmd.119.087148
  • Open Access
    Structure-Guided In Vitro to In Vivo Pharmacokinetic Optimization of Propargyl-Linked Antifolates
    M.N. Lombardo, N. G-Dayanandan, S. Keshipeddy, W. Zhou, D. Si, S.M. Reeve, J. Alverson, P. Barney, L. Walker, J. Hoody, N.D. Priestley, R.S. Obach and D.L. Wright
    Drug Metabolism and Disposition September 2019, 47 (9) 995-1003; DOI: https://doi.org/10.1124/dmd.119.086504
  • Open Access
    Single Nucleotide Polymorphisms at a Distance from Aryl Hydrocarbon Receptor (AHR) Binding Sites Influence AHR Ligand–Dependent Gene Expression
    Drew R. Neavin, Jeong-Heon Lee, Duan Liu, Zhenqing Ye, Hu Li, Liewei Wang, Tamas Ordog and Richard M. Weinshilboum
    Drug Metabolism and Disposition September 2019, 47 (9) 983-994; DOI: https://doi.org/10.1124/dmd.119.087312
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    GDC-0810 Pharmacokinetics and Transporter-Mediated Drug Interaction Evaluation with an Endogenous Biomarker in the First-in-Human, Dose Escalation Study
    Kit Wun Kathy Cheung, Kenta Yoshida, Sravanthi Cheeti, Buyun Chen, Roland Morley, Iris T. Chan, Srikumar Sahasranaman and Lichuan Liu
    Drug Metabolism and Disposition September 2019, 47 (9) 966-973; DOI: https://doi.org/10.1124/dmd.119.087924
  • Specificity of the Redox Complex between Cytochrome P450 24A1 and Adrenodoxin Relies on Carbon-25 Hydroxylation of Vitamin-D Substrate
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    Specificity of the Redox Complex between Cytochrome P450 24A1 and Adrenodoxin Relies on Carbon-25 Hydroxylation of Vitamin-D Substrate
    Amit Kumar and D. Fernando Estrada
    Drug Metabolism and Disposition September 2019, 47 (9) 974-982; DOI: https://doi.org/10.1124/dmd.119.087759
  • Arylacetamide Deacetylase Enzyme: Presence and Interindividual Variability in Human Lungs
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    Arylacetamide Deacetylase Enzyme: Presence and Interindividual Variability in Human Lungs
    Morena Gabriele, Paola Puccini, Marco Lucchi, Vittorio Aprile, Pier Giovanni Gervasi and Vincenzo Longo
    Drug Metabolism and Disposition September 2019, 47 (9) 961-965; DOI: https://doi.org/10.1124/dmd.119.087031
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    SULT4A1 Protects Against Oxidative-Stress Induced Mitochondrial Dysfunction in Neuronal Cells
    Mohammed I. Hossain, Joshua M. Marcus, Jun Hee Lee, Patrick L. Garcia, Jean-Philippe Gagné, Guy G. Poirier, Charles N. Falany and Shaida A. Andrabi
    Drug Metabolism and Disposition September 2019, 47 (9) 949-953; DOI: https://doi.org/10.1124/dmd.119.088047

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