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Alternative Splicing in the Cytochrome P450 Superfamily Expands Protein Diversity to Augment Gene Function and Redirect Human Drug Metabolism
Andrew J. Annalora, Craig B. Marcus and Patrick L. Iversen

Drug Metabolism and Disposition April 2017, 45 (4) 375-389; DOI: https://doi.org/10.1124/dmd.116.073254
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Intrinsic Clearance Assay Incubational Binding: A Method Comparison
Sofia Chen, Luna Prieto Garcia, Fredrik Bergström, Pär Nordell and Ken Grime

Drug Metabolism and Disposition April 2017, 45 (4) 342-345; DOI: https://doi.org/10.1124/dmd.116.074138
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Cholic Acid Feeding Leads to Increased CYP2D6 Expression in CYP2D6-Humanized Mice
Xian Pan, Rebecca Kent, Kyoung-Jae Won and Hyunyoung Jeong

Drug Metabolism and Disposition April 2017, 45 (4) 346-352; DOI: https://doi.org/10.1124/dmd.116.074013
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Regional Expression Levels of Drug Transporters and Metabolizing Enzymes along the Pig and Human Intestinal Tract and Comparison with Caco-2 Cells
Stefan F.C. Vaessen, Marola M.H. van Lipzig, Raymond H.H. Pieters, Cyrille A.M. Krul, Heleen M. Wortelboer and Evita van de Steeg

Drug Metabolism and Disposition April 2017, 45 (4) 353-360; DOI: https://doi.org/10.1124/dmd.116.072231
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A Physiologically-Based Pharmacokinetic Modeling Approach To Predict Drug–Drug Interactions of Sonidegib (LDE225) with Perpetrators of CYP3A in Cancer Patients
Heidi J. Einolf, Jocelyn Zhou, Christina Won, Lai Wang and Sam Rebello

Drug Metabolism and Disposition April 2017, 45 (4) 361-374; DOI: https://doi.org/10.1124/dmd.116.073585
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Difference in Mechanism-Based Inhibition of Cytochrome P450 3A4 and 3A5 by a Series of Fluoroquinolone Antibacterial Agents
Akiko Watanabe, Hideo Takakusa, Takako Kimura, Shin-ichi Inoue, Hiroyuki Kusuhara and Osamu Ando

Drug Metabolism and Disposition March 2017, 45 (3) 336-341; DOI: https://doi.org/10.1124/dmd.116.073783
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Pregnancy Increases the Renal Secretion of N¹-methylnicotinamide, an Endogenous Probe for Renal Cation Transporters, in Patients Prescribed Metformin
Mackenzie C. Bergagnini-Kolev, Mary F. Hebert, Thomas R. Easterling and Yvonne S. Lin

Drug Metabolism and Disposition March 2017, 45 (3) 325-329; DOI: https://doi.org/10.1124/dmd.116.073841
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Phenobarbital Treatment at a Neonatal Age Results in Decreased Efficacy of Omeprazole in Adult Mice
Yun-Chen Tien, Stephanie C. Piekos, Chad Pope and Xiao-bo Zhong

Drug Metabolism and Disposition March 2017, 45 (3) 330-335; DOI: https://doi.org/10.1124/dmd.116.073601
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Stereoselective Pharmacokinetics and Chiral Inversion of Ibuprofen in Adjuvant-induced Arthritic Rats
Hiroyuki Ikuta, Atsushi Kawase and Masahiro Iwaki

Drug Metabolism and Disposition March 2017, 45 (3) 316-324; DOI: https://doi.org/10.1124/dmd.116.073239
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Metabolism and Disposition of a Novel B-Cell Lymphoma-2 Inhibitor Venetoclax in Humans and Characterization of Its Unusual Metabolites
Hong Liu, Melissa J. Michmerhuizen, Yanbin Lao, Katty Wan, Ahmed Hamed Salem, James Sawicki, Michael Serby, Srirajan Vaidyanathan, Shekman L. Wong, Suresh Agarwal, Martin Dunbar, Jens Sydor, Sonia M. de Morais and Anthony J. Lee

Drug Metabolism and Disposition March 2017, 45 (3) 294-305; DOI: https://doi.org/10.1124/dmd.116.071613

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