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Drug Metabolism & Disposition

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Latest Articles

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    SULT4A1 Protects Against Oxidative-Stress Induced Mitochondrial Dysfunction in Neuronal Cells
    Mohammed I. Hossain, Joshua M. Marcus, Jun Hee Lee, Patrick L. Garcia, Jean-Philippe Gagné, Guy G. Poirier, Charles N. Falany and Shaida A. Andrabi
    Drug Metabolism and Disposition September 2019, 47 (9) 949-953; DOI: https://doi.org/10.1124/dmd.119.088047
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    Interactions between Maraviroc and the ABCB1, ABCG2, and ABCC2 Transporters: An Important Role in Transplacental Pharmacokinetics
    Lenka Tupova, Martina Ceckova, Csilla Ambrus, Ales Sorf, Zuzana Ptackova, Zsuzsanna Gaborik and Frantisek Staud
    Drug Metabolism and Disposition September 2019, 47 (9) 954-960; DOI: https://doi.org/10.1124/dmd.119.087684
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    Polybrominated Diphenyl Ethers and Gut Microbiome Modulate Metabolic Syndrome–Related Aqueous Metabolites in Mice
    David K. Scoville, Cindy Yanfei Li, Dongfang Wang, Joseph L. Dempsey, Daniel Raftery, Sridhar Mani, Haiwei Gu and Julia Yue Cui
    Drug Metabolism and Disposition August 2019, 47 (8) 928-940; DOI: https://doi.org/10.1124/dmd.119.086538
  • Open Access
    Defining the Contribution of CYP1A1 and CYP1A2 to Drug Metabolism Using Humanized CYP1A1/1A2 and Cyp1a1/Cyp1a2 Knockout Mice
    Y. Kapelyukh, C. J. Henderson, N. Scheer, A. Rode and C. R. Wolf
    Drug Metabolism and Disposition August 2019, 47 (8) 907-918; DOI: https://doi.org/10.1124/dmd.119.087718
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    Carfilzomib Is Not an Appropriate Payload of Antibody-Drug Conjugates Due to Rapid Inactivation by Lysosomal Enzymes
    Yong Ma, Josefa Dela Cruz-Chuh, S. Cyrus Khojasteh, Peter S. Dragovich, Thomas H. Pillow and Donglu Zhang
    Drug Metabolism and Disposition August 2019, 47 (8) 884-889; DOI: https://doi.org/10.1124/dmd.119.086595
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    Nitidine Chloride–Induced CYP1 Enzyme Inhibition and Alteration of Estradiol Metabolism
    Xu Mao, Jian Wang, Qian Wang, Lan Yang, Yilin Li, Hao Lin, Ying Peng and Jiang Zheng
    Drug Metabolism and Disposition August 2019, 47 (8) 919-927; DOI: https://doi.org/10.1124/dmd.119.086892
  • Altered Expression and Function of Hepatic Transporters in a Rodent Model of Polycystic Kidney Disease
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    Altered Expression and Function of Hepatic Transporters in a Rodent Model of Polycystic Kidney Disease
    Jacqueline Bezençon, James J. Beaudoin, Katsuaki Ito, Dong Fu, Sharin E. Roth, William J. Brock and Kim L.R. Brouwer
    Drug Metabolism and Disposition August 2019, 47 (8) 899-906; DOI: https://doi.org/10.1124/dmd.119.086785
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    Clinical Extrapolation of the Effects of Dolutegravir and Other HIV Integrase Inhibitors on Folate Transport Pathways
    Maciej J. Zamek-Gliszczynski, Xuexiang Zhang, Jennypher Mudunuru, Yewei Du, Jian-Lu Chen, Kunal S. Taskar, Jane Huang, Yong Huang and Elizabeth H. Romach
    Drug Metabolism and Disposition August 2019, 47 (8) 890-898; DOI: https://doi.org/10.1124/dmd.119.087635
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    Correction to “Complete Substrate Inhibition of Cytochrome P450 2C8 by AZD9496, an Oral Selective Estrogen Receptor Degrader”
    Drug Metabolism and Disposition August 2019, 47 (8) 883; DOI: https://doi.org/10.1124/dmd.119.081539err
  • Open Access
    Plasma Protein Binding as an Optimizable Parameter for Acidic Drugs
    Philip Gardiner, Rhona J. Cox and Ken Grime
    Drug Metabolism and Disposition August 2019, 47 (8) 865-873; DOI: https://doi.org/10.1124/dmd.119.087163

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